Case report
Platelet Mapping and Desmopressin Reversal of Platelet Inhibition During Emergency Carotid Endarterectomy

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Case Report

A 57-year-old man was admitted with a diagnosis of acute myocardial infarction. Medical history included arterial hypertension and dyslipidemia under medical treatment, smoking, and chronic obstructive pulmonary disease. The patient was not taking chronic platelet inhibitor therapy. Myocardial enzymes (including troponin T) and the electrocardiogram confirmed the diagnosis of an acute posterolateral myocardial infarction. The patient underwent an angiographic examination that revealed complete

Discussion

Thienopyridine (clopidogrel and ticlopidine) antiplatelet therapy may induce different degrees of platelet dysfunction depending on the dosage and the individual susceptibility. A 300-mg loading dose of clopidogrel is generally able to induce a decrease in platelet aggregability to about 60% of normal after 4 hours.6 Standard coagulation tests are inadequate to assess the degree of this drug-induced platelet dysfunction.

PFA-100 is approved for testing the extent of aspirin-induced platelet

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