Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Alzheimer disease

To what extent can Alzheimer disease be prevented?

Preventive strategies for Alzheimer disease (AD) will depend on the identification of modifiable risk factors for this disorder. A new study has quantified the relative contributions of seven major risk factors for AD, and concludes that around one-third of AD cases are likely to be preventable.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K. & Brayne, C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 13, 788–794 (2014).

    Article  Google Scholar 

  2. Barnes, D. E. & Yaffe, K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 10, 819–828 (2011).

    Article  PubMed  Google Scholar 

  3. Matthews, F. E. et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 382, 1405–1412 (2013).

    Article  PubMed  Google Scholar 

  4. Qiu, C., von Strauss, E., Bäckman, L., Winblad, B. & Fratiglioni, L. Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 80, 1888–1894 (2013).

    Article  Google Scholar 

  5. Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet http://dx.doi.org/10.1016/S0140–6736(14)60460–8.

  6. IDF Diabetes Atlas, 6th edn. International Diabetes Federation [online], (2013).

  7. Solomon, A. et al. Advances in the prevention of Alzheimer's disease and dementia. J. Intern. Med. 275, 229–250 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Kivipelto, M. et al. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 5, 735–741 (2006).

    Article  PubMed  Google Scholar 

  9. Kivipelto, M. et al. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress. Alzheimers Dement. 9, 657–665 (2013).

    Article  Google Scholar 

  10. Smith, A. D. & Yaffe, K. Dementia (including Alzheimer's disease) can be prevented: statement supported by international experts. J. Alzheimers Dis. 38, 699–703 (2014).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Miia Kivipelto.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kivipelto, M., Mangialasche, F. To what extent can Alzheimer disease be prevented?. Nat Rev Neurol 10, 552–553 (2014). https://doi.org/10.1038/nrneurol.2014.170

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2014.170

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing