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Emerging models and paradigms for stem cell ageing

Nature Cell Biology volume 13, pages 506–512 (2011)Cite this article

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Abstract

Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.

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Figure 1: Emerging paradigms for stem cell ageing.

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Acknowledgements

We apologize to those colleagues whose work could not be referenced directly owing to space constraints. D.L.J. is funded by the Emerald Foundation, the G. Harold and Leila Y. Mathers Charitable Foundation, the ACS, the California Institute for Regenerative Medicine (CIRM), and the NIH (R01 AG028092). T.A.R. is funded by the NIH (R37 AG23806, R01 AR056849 and an NIH Director's Pioneer Award), the Glenn Foundation for Medical Research, the Department of Veterans Affairs (Merit Review) and the Amertical Federation for Aging Research (“Breakthroughs in Gerontology” (BIG) Award).

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  1. D. Leanne Jones is at the Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA,

    D. Leanne Jones

  2. Thomas A. Rando is at The Glenn Laboratories for the Biology of Aging and the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford California 94305, USA, and the RR&D Center of Excellence and the Neurology Service, VAPAHCS, Palo Alto, California 94305, USA,

    Thomas A. Rando

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Jones, D., Rando, T. Emerging models and paradigms for stem cell ageing. Nat Cell Biol 13, 506–512 (2011). https://doi.org/10.1038/ncb0511-506

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