Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review
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Cited by (134)
Immunohistochemical localization of megalin and cubilin in the human inner ear
2018, Brain ResearchCitation Excerpt :In this respect blockage of megalin has been associated with suppression of nephrotoxicity mediated by gentamicin, vancomycin or cisplatin (Hori et al., 2017), and it has been suggested that single nucleotide polymorphisms (SNPs) in LRP2 may impact the individual susceptibility against cisplatin-induced ototoxicity (Riedemann et al., 2008). It is important to mention that there are other mechanisms of ototoxicity via the uptake and metabolism of aminoglycosides by auditory and vestibular hair cells (Lim, 1986; Richardson et al., 1997). Another role for megalin and cubilin located in the epithelial cells of the Reissner’s membrane may be participating in the endocytosis of debris accumulated in the endolymph after acoustic trauma (Hunter-Duvar, 1978).
Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae
2013, NeuroscienceCitation Excerpt :One of the leading causes of sensorineural hearing loss in adults is acoustic overstimulation, which can cause mechanical and metabolic stresses to the cochlear structure and consequently induce sensory cell degeneration (Lim, 1986; Bohne and Harding, 2000; Cheng et al., 2005; Henderson et al., 2006).
The efferent medial olivocochlear-hair cell synapse
2012, Journal of Physiology ParisCitation Excerpt :Hair cells of the inner ear are very few, when compared to the millions of photoreceptors of the retina: approximately 16,000 sensory hair cells in the human cochlea. In addition, mammalian hair cells do not regenerate after damage, thus it is important to protect the inner ear from insults such us exposure to loud sound (Lim, 1986; Brigande and Heller, 2009), which leads to pathologies such as hearing loss and tinnitus (Eggermont and Roberts, 2004; Elgoyhen and Langguth, 2010). Hair cells are organized in a tonotopic fashion (arranged by frequency sensitivity): those sensitive to high frequency sound are at the basal end nearer to the tympanic middle ear and those sensitive to low frequency are at the apical end of the coiled cochlea (Hudspeth, 1997).
An in vivo Biomarker to Characterize Ototoxic Compounds and Novel Protective Therapeutics
2022, Frontiers in Molecular NeuroscienceNoise-induced hearing loss correlates with inner ear hair cell decrease in larval zebrafish
2022, Journal of Experimental Biology
This study was supported in part by a grant from the Deafness Research Foundation and contracts from the U.S. Air Force (Aerospace Medical Research Laboratory, Wright-Pat-terson Air Force Base) and the National Institute of Occupational Safety end Health.