Organ donationCan We Accept Donors Who Have Suffered a Resuscitated Cardiac Arrest?
Section snippets
Materials and Methods
We included all 604 heart transplantations (HTs) performed in our center from January 1987 to September 2009 (Table 1), of including 25 recipients who received an organ from a patient who had undergone an RCA. We considered RCA to be an in-hospital event that was resuscitated from the onset, with a duration of less than 30 minutes, and with total recovery of cardiac and hemodynamic functions. We analyzed ischemia times, incidences of acute graft failure (AGF), intubation periods, recovery room
Results
There were no differences in the baseline characteristics of the two groups, except that patients in the RCA group were younger (47 ± 13 vs 51 ± 11 years; P = .50). There were also no differences between the RCA group and the other patients in ischemia time (151 ± 50 vs 154 ± 53 minutes; P = .826), incidence of AGF (33% vs 24.7%; P = .311), hours of intubation (76 ± 204 vs 72 ± 249; P = .926), days of recovery in the intensive care unit (6 ± 7 vs 8 ± 6; P = .453), or survival after HT (53 ± 54
Discussion
There is a growing disproportion between the supply of available organs and the number of recipients on the waiting list. This situation is due, on one hand, to improved treatments for various heart diseases, with an increase in the population that will ultimately develop end-stage heart failure, and, on the other hand, to the decrease in organ donors as a result of the reduction in traffic accidents,1 among other causes. Therefore, organs from donors that would previously not have been
References (4)
Spanish Heart Transplantation Registry20th official report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984–2008)
Rev Esp Cardiol
(2009)- et al.
Improving the rate of organ donation
Transplant Proc
(2004)
Cited by (12)
The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: A systematic review
2016, ResuscitationCitation Excerpt :Given this and for clarity the results have been presented according to organ transplanted. Fifteen of the studies4,15–28 reported data on DBD donors, this included paediatrics and adults. All 15 studies were observational in design; two were prospective18,24 and 13 retrospective.4,15–17,19–23,26–28
Part 4: Advanced life support. 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations
2015, ResuscitationCitation Excerpt :Two nonrandomized studies provided low-quality evidence that the mean yield of organs procured from donors who had been resuscitated by CPR before donation was 3.9339 or 2.9.340 For the important outcome of immediate graft survival, low-quality evidence from nonrandomized studies did not detect any worse outcome when donors have had CPR and resuscitation for adult hearts (3239 organs340–347), pediatric hearts (557 organs, 4 studies), adult lungs (1031 organs340,345,348), pediatric lungs (105 organs340), adult kidneys (5000 organs340,349), pediatric kidneys (1122 organs340,350), adult livers (2911 organs340,341), pediatric livers (689 organs340,350), adult intestines (25 organs340,351), and pediatric intestines (79 organs340). For the important outcome of graft survival for 1 year, low-quality evidence from nonrandomized studies did not detect any worse outcome when donors have had CPR and resuscitation for adult hearts (3230 organs340–342,344–347), pediatric hearts (1605 organs340,350,352,353), adult lungs (1031 organs340,345,348), pediatric lungs (105 organs340), adult kidneys (5000 organs340,341), pediatric kidneys (1122 organs340), adult livers (2911 organs340,341), pediatric livers (689 organs340), adult intestines (25 organs340,351), and pediatric intestines (79 organs340).
European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015. Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015.
2015, ResuscitationCitation Excerpt :All decisions concerning organ donation must follow local legal and ethical requirements, as these vary in different settings. Non-randomised studies have shown that graft survival at one year is similar from donors who have had CPR compared with donors who have not had CPR: adult hearts (3230 organs381–387), adult lungs (1031 organs383,385,388), adult kidneys (5000 organs381,383), adult livers (2911 organs381,383), and adult intestines (25 organs383). Non-randomised studies have also shown that graft survival at one year was similar when organs recovered from donors with ongoing CPR were compared to other types of donors for adult kidneys (199 organs389–391) or adult livers (60 organs390,392,393).
Increased cell-free DNA plasma concentration following liver transplantation is linked to portal hepatitis and inferior survival
2020, Journal of Clinical MedicinePost resuscitation care: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015
2017, Notfall und Rettungsmedizin