Regular ArticleReversal of rivaroxaban-induced anticoagulation with prothrombin complex concentrate, activated prothrombin complex concentrate and recombinant activated factor VII in vitro☆☆
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Abbreviations
ACCP
American College of Chest Physicians
ANOVA
analysis of variance
aPCC
activated prothrombin complex concentrate
CAT
calibrated automated thrombogram
Cmax
maximum concentration (of thrombin)
CT
clotting time
DMSO
dimethyl sulphoxide
ETP
endogenous thrombin potential
INR
international normalised ratio
LMWH
low molecular weight heparin
PCC
prothrombin complex concentrate
PPP
platelet-poor plasma
PT
prothrombin time
rFVIIa
recombinant activated factor VII
SEM
standard error of the mean
TEM
thromboelastometry
TF
tissue factor
TG
thrombin generation
UFH
unfractionated heparin
VKA
vitamin K antagonist
Keywords
Recombinant activated factor VII
Antidote
Prothrombin complex concentrate
Activated prothrombin complex concentrate
Rivaroxaban
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Presented at: ICT 2012 (22nd International Congress on Thrombosis), Nice, France, October 6–9 2012.
Copyright © 2014 The Authors. Published by Elsevier Ltd.