Society of University SurgeonsImpact of donor cardiac arrest on heart transplantation
Section snippets
Methods
The Institutional Review Board at Duke University Medical Center approved this study. Individual patient consent was deemed unnecessary.
Results
A total of 21,383 heart transplant recipients were included in the analysis. Of these, 930 (4.3%) had received their allografts from donors who had undergone cardiac arrest (Donor Arrest), and 20,453 came from donors without histories of cardiac arrest (No Arrest). Patients excluded from the final study population are summarized in Figure 1. The median follow-up time was 3.7 years. The Donor Arrest group had a greater incidence of sex mismatch (31% vs 27.6%, P = .02); race mismatch (46.5% vs
Discussion
The purpose of this study was to determine the impact of donor cardiac arrest on both short- and long-term outcomes after orthotopic heart transplantation. There were no differences in either 30-day mortality or overall survival between recipients of hearts with or without histories of donor cardiac arrest. Additionally, we demonstrated that increasing duration of arrest time was significantly associated with decreasing survival.
Current outcomes after heart transplantation are excellent and
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Up to an Hour of Donor Resuscitation Does Not Affect Pediatric Heart Transplantation Survival
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2023, Journal of Heart and Lung TransplantationDonor heart selection and outcomes: An analysis of over 2,000 cases
2018, Journal of Heart and Lung TransplantationImpact of cardiac arrest resuscitated donors on heart transplant recipients' outcome
2017, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :The strength of protection by ischemic preconditioning critically depends on the duration from the end of preconditioning ischemia to the onset of the subsequent ischemia; in fact, the protective effects of preconditioning are transient and last for less than 2 hours19; however, a so-called second window of protection or delayed ischemic preconditioning has been shown to occur 24 hours after the preconditioning stimulus and lasting for about 48 hours.20 Of note, we found no difference in recipient survival with respect to the duration of cardiac arrest in donors; these results are in contrast with previous report showing that increasing duration of cardiac arrest in donors was associated with decreased survival in recipients.21 Despite the presence of more patients with preoperative LVAD in the CARD+ group, early and late survival in this group was not inferior to the CARD− group.
The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: A systematic review
2016, ResuscitationCitation Excerpt :Fifteen of the studies4,15–28 reported data on DBD donors, this included paediatrics and adults. All 15 studies were observational in design; two were prospective18,24 and 13 retrospective.4,15–17,19–23,26–28 Two papers reported the mean yield of organs procured from CPR+ DBD donors as 3.929 or 2.9.15