Short communicationInterleukin-6 −174G/C polymorphism and longevity: a follow-up study
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Acknowledgements
This work was supported by grants from The Research Foundation of Tampere University Hospital, The Tampere Tuberculosis Foundation and Emil Aaltonen Foundation.
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Analysis of the levels of inflammatory parameters in persons over the age of 90
2021, Experimental GerontologyWhole-Genome Sequencing of a Healthy Aging Cohort
2016, CellCitation Excerpt :Our variant filtration strategy was reinforced by observing no evidence of genomic inflation in the genome-wide association results (see below; λ = 0.98) (Reich and Goldstein, 2001). First, we explored whether previously reported longevity variants may underlie the Wellderly phenotype (Atzmon et al., 2006; Bojesen and Nordestgaard, 2008; Hurme et al., 2005; Kuningas et al., 2007; Melzer et al., 2007; Pawlikowska et al., 2009; Sanders et al., 2010; Suh et al., 2008; Willcox et al., 2008). No deviation in allele frequency of longevity variants was observed between the Wellderly cohort and the ITMI cohort or the 1000 Genomes European individuals (Sudmant et al., 2015) (Table 2).
The genetics of exceptional longevity: Insights from centenarians
2016, MaturitasCitation Excerpt :Evidence exists of inverse correlation between levels of certain inflammatory molecules such as interleukin (IL)-6 and longevity. Thus, higher levels of this IL appear to lead to increased mortality at an advanced age [84]. The IL-6 gene, located on the 7p21 chromosome, is expressed in lymphocytes, fibroblasts and macrophages in response to different inflammatory stimuli.
Genetic Mechanisms of Aging
2010, Brocklehurst's Textbook of Geriatric Medicine and GerontologyPolymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study
2009, AtherosclerosisCitation Excerpt :In this study and in a later one conducted at a separate institute, the IL6 allele C was significantly associated with high levels of CRP [4,10]. The frequency of IL6 −174 allele C seems to decrease in nonagenarians, suggesting that this allele predicts, to a certain extent, mortality in the older age groups [11]. In a recent prospective cohort study with 6434 participants >55 years of age, a trend appeared towards increased risk of coronary heart disease for subjects with the GC and CC genotype.