Original ArticleQuantitative End-Tidal Carbon Dioxide Monitoring in the Delivery Room: A Randomized Controlled Trial
Section snippets
Methods
This is a prospective randomized controlled trial to evaluate the effectiveness of a quantitative Etco2 device at improving mechanical ventilation in the DR. The University of California, San Diego Medical Center institutional review board approved the trial, which was registered with ClinicalTrials.gov (NCT1381068). Antenatal consents were obtained from mothers admitted to the labor and delivery unit whose delivery was considered high risk for resuscitation.
All infants were born between
Results
The number of families approached for the study and randomization numbers are shown in Figure 2. The demographic characteristics were similar between groups (Table I). Most of the infants enrolled were <32 weeks' gestation (n = 38). None of the 12 infants ≥32 weeks were intubated in the DR. Of the 48 patients with primary outcome data, 19 complete Etco2 tracings were available in the control arm and 18 complete Etco2 tracings were available in the monitored arm. Eleven patients did not have
Discussion
The primary outcome of our study, the proportion of Pco2 levels outside of the targeted range, was not reduced significantly with Etco2 monitoring in the DR. This study was originally designed to evaluate Etco2 monitoring as a method of improving ventilation in intubated infants in the DR. Our practice shifted during the time period of the study toward less invasive ventilation. Therefore, the majority of subjects were treated with mask ventilation initially and CPAP alone by the end of
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The authors declare no conflicts of interest.
Study was registered with ClinicalTrials.gov: NCT1381068.