ReviewEffectiveness of Nutritional Supplementation on Muscle Mass in Treatment of Sarcopenia in Old Age: A Systematic Review
Section snippets
Methods
We performed this systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for systematic reviews.23 The protocol of this systematic review was registered at PROSPERO, as CRD42012002546, which is an international database of prospectively registered systematic reviews in health and social care. PROSPERO is funded by the UK National Institute for Health Research (available at: //www.crd.york.ac.uk/PROSPERO/display_record.asp%3FID=CRD42012002546
Results
Figure 1 shows the flow chart of the articles we found, the ones we discarded, and the ones we included in the review. One hundred sixty-eight citations came from MEDLINE, 20 came from the search in the Cochrane Library, and 12 from the references of the included articles, from all of which, after removing duplicates, we were left with 176 papers resulted. One hundred fifty-two were discarded because they did not fulfill the inclusion criteria set by the design of this review. The full text of
Discussion
All the papers reviewed refer to sarcopenia in their introduction and mention sarcopenia often in the discussion but only three of the trials included sarcopenic patients. In one of them, the criteria used to define sarcopenia differ from those accepted by international consensus and the other two do not specify the criteria used.
Patients with a BMI higher than 20 kg/m2 were included in 53% of the trials and 30% included patients with a BMI above 27 kg/m2. Despite the severe limitations the
Conclusion
We found two papers assessing the effects of nutritional supplementation on muscle mass and function in patients with hip fractures that were published in the “Journal” last month.53, 54 These further support our conclusions. Some of the papers reviewed did not achieve positive results, but showed negative effects on untreated groups, which may be an indirect indication of the protective effect of nutritional supplementation in terms of the consequences of ageing.
The right kind of diet and a
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The authors have no financial or any other kind of personal conflicts with this paper.
This review was registered at www.crd.york.ac.uk/prospero/prospero.asp (PROSPERO), as CRD42012002546.