The Egyptian Heart Journal

The Egyptian Heart Journal

Volume 68, Issue 3, September 2016, Pages 197-199
The Egyptian Heart Journal

CASE REPORT
Acquired long QT syndrome and Torsades de Pointes related to donepezil use in a patient with Alzheimer disease

https://doi.org/10.1016/j.ehj.2015.07.004Get rights and content
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open access

Abstract

Acetylcholinesterase inhibitors are group of drugs commonly used in Alzheimer disease and have beneficial effects on treatment. Although they have many known side effects, cardiovascular side effects are rarely seen. We present a 84 year old female who was admitted to emergency service due to repetitive syncope episodes while taking donepezil. Her electrocardiogram showed QT prolongation and on follow-up a Torsades de Pointes episode occurred. Patient was discharged with normal corrected QT time after removal of donepezil.

Keywords

Donepezil
AChIs
Torsades de Pointes
QT prolongation
Syncope

Cited by (0)

Peer review under responsibility of Egyptian Society of Cardiology.