Preventive cardiologyCirculating Levels of Endothelial Progenitor Cell Mobilizing Factors in the Metabolic Syndrome
Section snippets
Methods
All subjects were recruited from Sacramento County through fliers and advertisements in the newspaper. Subjects (aged 21 to 70 years) with MS (n = 36) and healthy controls (n = 38) were studied. MS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III.10 Control subjects needed to have ≤2 features of MS and not be taking blood pressure medications. Other selection criteria have been published previously.8 None of the subjects had diabetes or
Results
The 2 groups were matched for age and gender. All metabolic features, including homeostasis model assessment and high-sensitivity C-reactive protein, were significantly increased in patients with MS, and high-density lipoprotein cholesterol levels were significantly decreased (Table 1). Also, levels of PCs and EPCs were significantly decreased in patients with MS (p <0.05).
With respect to the mobilizing factors, the most significant difference was seen with granulocyte colony-stimulating factor
Discussion
We and others have previously shown that PCs and EPCs are decreased in patients with MS.6, 7, 8, 9 This finding was further confirmed in this study with a smaller sample size. This observation might have profound implications in terms of cardiovascular risk, because CD34+ cells12 and CD34+ and kinase insert domain receptor–positive cells4, 5 predict incident cardiovascular events and regulate cardiovascular homeostasis. However, the causes of PC and EPC pauperization in MS remain unclear.
Acknowledgment
We would like to thank Manpreet Kaur, University of California Davis Medical Center, for manuscript preparation.
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Cited by (0)
Dr. Jialal was supported by grant K-24 AT00596 from the National Institutes of Health, Bethesda, Maryland, and by a grant from the American Diabetes Association, Alexandria, Virginia.