General Obstetrics and Gynecology: ObstetricsFamilial aggregation of small-for-gestational-age births: The importance of fetal genetic effects
Section snippets
Data sources
The Swedish Multi-Generation Register includes 8.5 million children born since 1932, who are linked with their biological parents, resulting in a total of 11 million unique individuals.7 Since 1973, data on all births in Sweden (including information on demographics, reproductive history, and complications during pregnancy, delivery, and the neonatal period) are collected prospectively and recorded in the Medical Birth Register. By the end of 2001, there were 2.9 million births recorded,
Results
Among the 2,193,142 singleton births, the incidence of SGA births was 4.2% in the first pregnancy and 2.3% in the following pregnancies.
Table II presents the distribution of SGA births and the corresponding ORs in the different sibships. For example, in the 227,905 families joined by full sisters, there were 200,893 families in which none of the sisters had a SGA birth; 25,255 families in which 1 sister had a SGA birth; 1,690 families in which 2 sisters had SGA births; and 67 families in which
Comment
Our results corroborate previous findings that familial factors influence risk of SGA.5, 6, 16 Further, we could show that approximately 46% of the variation in liability to giving birth to a SGA offspring can be explained by genetic factors, of which fetal genes constitute 37% and maternal genes 9%. There is variability among individuals in their susceptibility to SGA births; about 46% of this variability is due to genes and 54% is due to environmental factors.
To our knowledge, this is the
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Cited by (70)
Intergenerational trends in reproduction: Infertility and pregnancy loss
2023, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :There is a recognised familial predisposition to pre-eclampsia, whereby a family history of pre-eclampsia appears to confer increased risk to offspring[2,5,78]. Studies have also consistently shown a positive intergenerational association for growth restriction passed from mothers to offspring[81-83]. One study also found a familial association with placental abruption in mother to offspring pairs (adjusted Odds Ratio (aOR) 1.60 (95%CI 1.23-2.09))[78].
Progesterone partially recovers placental glucose transporters in dexamethasone-induced intrauterine growth restriction
2022, Reproductive BioMedicine OnlineCitation Excerpt :Most of the IUGR cases are idiopathic, however the known causes are fetal, maternal or placental. Genetic factors account for 30–50% of birthweight variations (Svensson et al., 2006). Maternal factors include disorders that result in hypoxia, such as coronary vascular disease and haematological disorders as well as respiratory problems.
Inherited predisposition to stillbirth: an intergenerational analysis of 26,788 mother-daughter pairs
2019, American Journal of Obstetrics and GynecologyFetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome
2016, Genetics in MedicineAdverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study
2018, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :For placental abruption, however, the positive association with maternal asthma was attenuated in comparisons of cousins and siblings discordant for asthma exposure. This implies that the associations with maternal asthma may be confounded by factors shared within families, such as genetic predisposition,29,30 health management behavior, and exposure to environmental agents. However, placental abruption may have other causes, not likely to be shared within families, such as abdominal trauma during pregnancy, chorioamnionitis, and previous cesarean section.31
Funded by the Swedish Council for Working Life and Social Research (project 2003-0274).