ViewpointDoing damage in delirium: the hazards of antipsychotic treatment in elderly people
References (33)
- et al.
Delirium in elderly people
Lancet
(2014) - et al.
Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: a review of data from prospective, randomised studies
Best Pract Res Clin Anaesthesiol
(2012) - et al.
Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial
Lancet Respir Med
(2013) - et al.
Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial
Psychosomatics
(2010) - et al.
Delirium in hospitalized patients: implications of current evidence on clinical practice and future avenues for research—a systematic evidence review
J Hosp Med
(2012) Johnson & Johnson to pay $2.2 billion to settle U.S. probes: deal with Justice Department regards drug maker's selling of antipsychotic Risperdal
The Wall Street Journal
(Nov 4, 2013)- et al.
Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence
J Gerontol A Biol Sci Med Sci
(2008) - et al.
Delirium: screening, prevention, and diagnosis—a systematic review of the evidence
(2011) - et al.
Antipsychotics in the treatment of delirium in older hospitalized adults: a systematic review
J Am Geriatr Soc
(2011) - et al.
Synopsis of the National Institute for Health and Clinical Excellence guideline for prevention of delirium
Ann Intern Med
(2011)
Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial
Anesthesiology
Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial
Crit Care Med
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
Crit Care Med
Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery
Anaesth Intensive Care
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study
J Am Geriatr Soc
Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis
JAMA
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2023, Transplantation and Cellular TherapySafety and effectiveness of benzodiazepines and antipsychotics for agitation in older adults in the emergency department
2023, American Journal of Emergency MedicineAssociation of pharmacological prophylaxis with the risk of pediatric emergence delirium after sevoflurane anesthesia: An updated network meta-analysis
2021, Journal of Clinical AnesthesiaCitation Excerpt :No language restrictions or publication dates were applied. We also conducted manual searches for potentially eligible articles from the reference lists of review articles or pairwise meta-analysis [11,21–28]. The PICO applied in the current NMA was as follows: (1) patient or problem: pediatric patients (age under 18 years old) undergoing general anesthesia with sevoflurane; (2) intervention: pharmacological interventions applied during general anesthesia with sevoflurane; (3) comparator: placebo-controlled or active-controlled; and (4) outcome: the incidence of emergence delirium after sevoflurane anesthesia.
Managing Delirium and Agitation in the Older Emergency Department Patient: The ADEPT Tool
2020, Annals of Emergency MedicineCitation Excerpt :One is the best timing and use of medications for delirium. Although medications such as antipsychotics may help manage symptoms, they do not provide any outcome benefit in terms of hospital or ICU length of stay, disposition, or mortality.29,62-66 Although many authors recommend avoiding antipsychotic medications in all but the most agitated delirious patients, most of the studies were performed on admitted patients, providing little evidence in regard to optimal ED treatment.