Special contributionExperimental amitriptyline intoxication: Treatment of cardiac toxicity with sodium bicarbonate
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Acute Cardiovascular Toxicity of Cocaine
2022, Canadian Journal of CardiologyCitation Excerpt :The use of fibrinolytics is recommended in patients without contraindications if ST segments remain elevated despite appropriate treatment with nitroglycerin and calcium channel blockers, and if coronary angiography is not possible.109 Sodium bicarbonate is routinely used in the treatment of QRS prolongation from sodium channel blocking agents.124,125 Several studies in humans and other animals have shown the ability of sodium bicarbonate to significantly decrease cocaine-induced QRS prolongation.126-129
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis
2014, Behavioural Brain ResearchCitation Excerpt :In clinical practice, antidepressants are known to have deleterious effects when administered to non-depressed patients [42] comprising, amongst others, sedation, lower reaction time in the choice reaction time task, sensory impairments, disruption of discrimination ability, dry mouth, dizziness and constipation [42,43]. In what concerns the effects of prolonged AMI administration to animals only a few works reported frequency-related depression of ventricular conduction in dogs [44,45]. Nonetheless, in a preliminary study (unpublished data) where we compared the motor performance of AMI- and SAL-treated SHAM animals in the Rotarod test (increasingly faster rotations) no differences could be found between experimental groups.
"Recreational" Drugs
2012, Small Animal Toxicology, Third EditionRemoval of amitriptyline from simulated gastric and intestinal fluids using activated carbons
2011, Journal of Pharmaceutical Sciences
Supported by grants from the Medical Research Council of Canada and the Quebec Heart Foundation.
Presented at the UAEM/IRIEM Research Symposium on Toxicology in San Francisco, California, February 1986.