CommentCardiac regeneration: messages from CADUCEUS
References (11)
- et al.
Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
Lancet
(2004) - et al.
Myoblast transplantation for heart failure
Lancet
(2001) - et al.
Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
Lancet
(2003) - et al.
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
Lancet
(2011) - et al.
Executive summary: heart disease and stroke statistics—2012 update: a report from the American Heart Association
Circulation
(2012)
Cited by (26)
Cardiac cell therapy: Current status and future trends
2014, Cardiac Regeneration and RepairImportance of insulin resistance to vascular repair and regeneration
2013, Free Radical Biology and MedicineCitation Excerpt :Although not yet studied, vector targeting of signaling molecules downstream of multiple growth factors may also prove effective in bypassing growth factor resistance and so augmenting vascular renewal; however, more significant side effects might also be anticipated. Clinical trials of diverse autologous and allogeneic cell lines in the context of ischemic heart disease are currently ongoing, with mixed success in terms of surrogate outcomes; adequately powered studies of hard clinical outcomes are awaited [271–273]. These studies have not specifically recruited patients with insulin resistance or diabetes, yet such patients are likely to represent a majority in any cohort with established ischemic heart disease [9].
Towards regenerative therapy for cardiac disease
2012, The LancetCitation Excerpt :These results led to the initiation of several phase 1 clinical trials involving heart-derived cells: ALCADIA (NCT00981006), SCIPIO (NCT00474461), and CADUCEUS (NCT00893360). Preliminary results from the SCIPIO and CADUCEUS trials were recently published.38–40 Both studies were designed to assess the feasibility and safety of intracoronary injection of autologous heart-derived cells after recent infarction.
Gelatin-based hydrogels combined with electrical stimulation to modulate neonatal rat cardiomyocyte beating and promote maturation
2021, Bio-Design and ManufacturingMesenchymal stem cells and vascular regeneration
2017, Microcirculation