CommentAntidepressant treatment in Alzheimer's disease
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The course of neuropsychiatric symptoms in Dementia: A 3-year longitudinal study
2015, Journal of the American Medical Directors AssociationCitation Excerpt :It is unclear whether this reflects decreasing effectiveness in reducing these symptoms over time or simply more frequent prescribing, albeit with limited effectiveness, in response to increasing symptoms over time. Antidepressants were associated with greater depression and irritability, reflecting their use for these conditions and also perhaps their limited effectiveness in treating depression in the context of dementia.39–41 Interestingly, atypical antipsychotics were associated with baseline levels of a wide range of neuropsychiatric symptoms in addition to delusions and hallucinations, such as agitation, depression, anxiety, apathy, irritability, aberrant motor behavior, and night time behavior.
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