Research LettersEffect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury
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Cited by (48)
Treatment of paracetamol overdose: Room for improvement?
2014, The LancetN-acetylcysteine administration does not improve patient outcome after liver resection
2013, HPBCitation Excerpt :NAC has been previously reported to result in a prolonged PT in healthy volunteers through direct effects on the vitamin K‐dependent clotting factors II, VII, IX and X.[32,33] This may occur as a result of NAC‐mediated interruption of disulphide bonds necessary for the function of these clotting factors.[34] As a result of these and other studies, caution has been advised in making the assumption that a prolonged PT equates to impaired liver function in patients being treated with NAC.[35] Patients in this study did not undergo a formal assessment of the functional reserve of the liver such as the LiMAx test or measurement of the indiocyanine green retention rate.[36,37]
A Review of Acetaminophen Poisoning
2012, Critical Care ClinicsCitation Excerpt :NAC has also been implicated as a cause of an early increase in the INR. Here too the increase observed was modest, to about 1.3.114 This effect has been observed in patients receiving NAC without APAP present.115
Laboratory Testing for Liver Disease
2012, Zakim and Boyer's HepatologyUltraviolet derivatization of low-molecular-mass thiols for high performance liquid chromatography and capillary electrophoresis analysis
2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :N-acetylcysteine (NAcCys) is an endogenous product of cysteine metabolism. Moreover, it is a drug widely used for the treatment of paracetamol overdose [42] and as mucolytic agent for administration into respiratory tracts to loosen secretions [43]. NAcCys reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease [44] and prevents the reduction in renal function induced by iopromide, a nonionic, low-osmolality contrast agent, in patients with chronic renal insufficiency [45].
Critical care management of patients before liver transplantation
2010, Transplantation ReviewsCitation Excerpt :Oral NAC has few potential adverse effects that include nausea, vomiting, rare urticaria, and bronchospasm. Intravenous NAC may lead to rare anaphylaxis, electrocardiographic abnormalities, bronchospasm, and false improvements in international normalized ratio (INR) [27,28]. In our experience, both oral NAC and IV NAC are well tolerated without any significant adverse effects.