Selected topics toxicologyTricyclic antidepressant overdose: Conservative management in a community hospital with cost-saving implications
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Cited by (15)
European Resuscitation Council Guidelines for Resuscitation 2015. Section 4. Cardiac arrest in special circumstances
2015, ResuscitationCitation Excerpt :Anticholinergic effects include mydriasis, fever, dry skin, delirium, tachycardia, ileus, and urinary retention. Most life-threatening problems occur within the first 6 h after ingestion.301–303 A widening QRS complex (>100 ms) and right axis deviation indicates a greater risk of arrhythmias.304–306
Antidepressant Overdose-induced Seizures
2013, Psychiatric Clinics of North AmericaCitation Excerpt :If they remain without signs or symptoms of toxicity, a decision on disposition can be rendered; the patient may require psychiatric evaluation or can be discharged home. Patients who have ingested CAs and who are asymptomatic on presentation, receive activated charcoal, remain asymptomatic for a minimum of 6 hours in the treating facility without any treatment intervention, and have normal ECGs can receive disposition as deemed appropriate.86 Some exceptions that necessitate prolonged monitoring include ingestion of (1) sustained-release formulations, (2) drugs that can cause delayed-onset seizures (eg, bupropion or citalopram), or (3) antidepressants that can cause cardiotoxicity, such as bupropion,85 citalopram and escitalopram,35 or venlafaxine.45
Antidepressant Overdose-induced Seizures
2011, Neurologic ClinicsCitation Excerpt :If they remain without signs or symptoms of toxicity, a decision on disposition can be rendered; the patient may require psychiatric evaluation or can be discharged home. Patients who have ingested CAs and who are asymptomatic on presentation, receive activated charcoal, remain asymptomatic for a minimum of 6 hours in the treating facility without any treatment intervention, and have normal ECGs can receive disposition as deemed appropriate.86 Some exceptions that necessitate prolonged monitoring include ingestion of (1) sustained-release formulations, (2) drugs that can cause delayed-onset seizures (eg, bupropion or citalopram), or (3) antidepressants that can cause cardiotoxicity, such as bupropion,85 citalopram and escitalopram,35 or venlafaxine.45
European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution
2010, ResuscitationCitation Excerpt :Anticholinergic effects include mydriasis, fever, dry skin, delirium, tachycardia, ileus, and urinary retention. Most life-threatening problems occur within the first 6 h after ingestion.50–52 A widening QRS complex (>100 ms) and right axis deviation indicates a greater risk of arrhythmias.53–55
Tricyclic antidepressant agents
2005, ECG in Emergency Medicine and Acute CareECG abnormalities in tricyclic antidepressant ingestion
1999, American Journal of Emergency Medicine