Elsevier

Resuscitation

Volume 27, Issue 2, March 1994, Pages 159-170
Resuscitation

Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs

https://doi.org/10.1016/0300-9572(94)90009-4Get rights and content

Abstract

This study investigated the effects of normoxic (FIO2 = 0.21), hyperoxic (FIO2 = 1.0), and hyperoxic (FIO2 = 1.0) plus antioxidant pretreatment (tirilizad mesylate) resuscitation on neurologic outcome following 9 min of normothermic (39 ± 1.0°C) cardiac arrest. Physiologic variables including arterial blood gases and neurologic outcome, which was assessed using a standardized scoring system, were followed over a 24-h period following resuscitation from cardiac arrest. Hyperoxically resuscitated dogs sustained significantly worse neurological deficit at 12 and 24 h (mean scores: 39 ± 3 and 49 ± 8, respectively) than did antioxidant pretreated hyperoxically resuscitated dogs (mean scores: 22 ± 1, P = 0.0007 and 22 ± 1, P = 0.004, respectively) and normoxically resuscitated dogs (mean scores: 28 ± 4, P = 0.025 and 33 ± 8, P = 0.041 respectively). These data suggest that oxidant injury has a major role in central nervous system dysfunction following successful resuscitation from 9 min of cardiac arrest. Also, resuscitation from cardiac arrest with hyperoxic FIO2's may contribute to and further exacerbate neurologic dysfunction.

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