Early effects of nimodipine on intracanial and cerebral perfusion pressures in cerebral anoxia after out-of-hospital cardiac arrest☆
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Cited by (25)
European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care
2021, ResuscitationCitation Excerpt :Results from a post hoc analysis of the TTM-trial suggest that if there is severe cardiovascular impairment at 33 °C a higher temperature might be targeted.232 In contrast to a number of positive results from studies in experimental settings,18 several neuroprotective drugs failed to demonstrate a positive clinical effect.164,193,194,244–247 More recently, erythropoietin,248 cyclosporine,249 and exenatide,250 used alone, or as an adjunct to mild induced hypothermia, have also not been shown to increase neurologically intact survival when included in the post arrest treatment of cardiac arrest patients.
Neuroprotective strategies and neuroprognostication after cardiac arrest
2015, Best Practice and Research: Clinical AnaesthesiologyCitation Excerpt :Similarly, nimodipine administration was associated with better cerebral oxygenation and neuronal activity in an experimental model of CA [46,47]. In the clinical setting, nimodipine therapy was associated with a significant reduction in intracranial pressure after CA when compared with untreated patients [48]. In a randomized clinical trial on OHCA (n = 155), nimodipine injection administered immediately after ROSC did not improve the 1-year survival rate (40% vs. 36%) compared with the placebo.
European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support
2010, ResuscitationCitation Excerpt :Generally recognised contraindications to therapeutic hypothermia, but which are not applied universally, include: severe systemic infection, established multiple organ failure, and pre-existing medical coagulopathy (fibrinolytic therapy is not a contraindication to therapeutic hypothermia). Neuroprotective drugs (coenzyme Q10,737 thiopental,757 glucocorticoids,758,759 nimodipine,760,761 lidoflazine,762 or diazepam452) used alone, or as an adjunct to therapeutic hypothermia, have not been demonstrated to increase neurologically intact survival when included in the post-arrest treatment of cardiac arrest. There is also insufficient evidence to support the routine use of high-volume haemofiltration763 to improve neurological outcome in patients with ROSC after cardiac arrest.
Part 8: Advanced life support: 2010 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
2010, ResuscitationCitation Excerpt :Four RCTs (LOE 1) using nimodipine,882,883 lidoflazine,884 or diazepam732 in out-of-hospital cardiac arrest showed no benefits from any of the drugs when compared with standard care. Two RCTs (LOE 1) using thiopental884 or nimodipine885 in out-of-hospital cardiac arrest were unable to show any benefits when compared with standard care. A retrospective analysis using glucocorticoids in out-of-hospital cardiac arrest was unable to show any benefits when compared with standard care (LOE 2).877
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Lecture from the 2nd International Symposium on Nimodipine, Miami Beach, Florida, U.S.A.