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Guidelines for the Evaluation and Management of Status Epilepticus

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Abstract

Status epilepticus (SE) treatment strategies vary substantially from one institution to another due to the lack of data to support one treatment over another. To provide guidance for the acute treatment of SE in critically ill patients, the Neurocritical Care Society organized a writing committee to evaluate the literature and develop an evidence-based and expert consensus practice guideline. Literature searches were conducted using PubMed and studies meeting the criteria established by the writing committee were evaluated. Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.

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Acknowledgments

The committee would like to recognize and thank the following experts (listed alphabetically) who reviewed the committee’s initial recommendations and provided changes that were incorporated into the final guideline: Aaron Cook, Jeffrey Frank, Jennifer Fugate, Kathleen Hubner, Andrew Kofke, Andreas H. Kramer, Marek Mirski, Andrea Rossetti, Robert Silbergleit, and Panayiotis N. Varelas.

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Authors and Affiliations

  1. Departments of Pharmacotherapy & Outcomes Science and Neurosurgery, Virginia Commonwealth University, Medical College of Virginia Campus, 410 N. 12th Street, P.O. Box 980533, Richmond, VA, 23298-0533, USA

    Gretchen M. Brophy

  2. Thomas Jefferson University, Philadelphia, PA, USA

    Rodney Bell & Michael R. Sperling

  3. Columbia University, New York, NY, USA

    Jan Claassen

  4. University of California, San Francisco, San Francisco, CA, USA

    Brian Alldredge

  5. Rush University, Chicago, IL, USA

    Thomas P. Bleck

  6. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Tracy Glauser

  7. Emory University, Atlanta, GA, USA

    Suzette M. LaRoche

  8. New York University, New York, NY, USA

    James J. Riviello Jr.

  9. University of Cincinnati Medical Center, Cincinnati, OH, USA

    Lori Shutter

  10. Arizona State University, Tempe, AZ, USA

    David M. Treiman

  11. University of California, Los Angeles, Los Angeles, CA, USA

    Paul M. Vespa

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  1. Gretchen M. Brophy
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  2. Rodney Bell
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Neurocritical Care Society Status Epilepticus Guideline Writing Committee

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Correspondence to Gretchen M. Brophy.

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Brophy, G.M., Bell, R., Claassen, J. et al. Guidelines for the Evaluation and Management of Status Epilepticus. Neurocrit Care 17, 3–23 (2012). https://doi.org/10.1007/s12028-012-9695-z

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