REFERENCES
Patient-centered care for older adults with multiple chronic conditions: a stepwise approach from the american geriatrics society: American geriatrics society expert panel on the care of older adults with multimorbidity. J Am Geriatr Soc. 2012;60(10):1957–68.
Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716–24.
Weiss CO, BOyd CM, Wolff JL, Leff B. Patterns of prevalent major chronic disease among older adults in the United States. JAMA. 2007;298(10):1160–2.
Weiss CO, Varadhan R, Puhan M, Vickers A, Bandeen-Roche K, Boyd CM, Kent DM. Multimorbidity and Evidence Generation. JGIM. 2013, doi:10.1007/s11606-013-2660-5.
Trikalinos T, Segal J, Boyd CM. Addressing Multimorbidity in Evidence Integration and Synthesis. JGIM. 2013, doi:10.1007/s11606-013-2661-4.
Uhlig K, Leff B, Kent DM, Dy S, Brunnhuber K, Burgers J, Greenfield S, Guyatt G, High K, Leipzig R, Mulrow C, Schmader K, Schunemann H, Walter L, Woodcock J, Boyd CM. A framework for making clinical practice guidelines more relevant to the care and management of people with multimorbidity. JGIM. 2013, doi:10.1007/s11606-013-2659-y.
Vickers AJ, Scardino PT. The clinically-integrated randomized trial: proposed novel method for conducting large trials at low cost. Trials. 2009;10:14.
Califf R, Filerman GL, Murray RK, Rosenblatt M. http://www.iom.edu/∼/media/Files/Perspectives-Files/2012/Discussion-Papers/Drug%20Forum-Call%20for%20CTE.pdf. Accessed September 18, 2013.
Kuhn T. The Structure of Scientific Revolutions. Chicago: IL University of Chicago Press; 1996.
Acknowledgements
This manuscript was partially funded by grants R21 HS18597, R21 HS017653 from the Agency for Healthcare Research and Quality and UL1RR025752 from the National Institutes of Health. Dr. Boyd’s effort was supported in part by the Johns Hopkins Bayview Center for Innovative Medicine, The Robert Wood Johnson Foundation Physician Faculty Scholars Program, and the Paul Beeson Career Development Award Program (NIA K23 AG032910, AFAR, The John A. Hartford Foundation, The Atlantic Philanthropies, The Starr Foundation, and an anonymous donor).
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Boyd, C.M., Kent, D.M. Evidence-Based Medicine and the Hard Problem of Multimorbidity. J GEN INTERN MED 29, 552–553 (2014). https://doi.org/10.1007/s11606-013-2658-z
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DOI: https://doi.org/10.1007/s11606-013-2658-z