Zusammenfassung
Hintergrund
Adipositas bei Schwangeren stellt ein zunehmendes Problem dar, das mit z. T. gravierenden geburtshilflichen Problemen einhergeht. Betroffene Frauen mit Kinderwunsch sollten hierüber aufgeklärt werden, um sie zur Gewichtsabnahme vor der Schwangerschaft zu motivieren.
Risiken von Übergewicht bei Kinderwunsch
Sie nehmen mit dem BMI (Body-Mass-Index) der Frauen zu. Die Fertilität ist bei Adipositas reduziert. Bei adipösen Schwangeren ist das Risiko für einen Abort und kongenitale Fehlbildungen erhöht. Im Lauf der Schwangerschaft kommen Hypertonus, Gestationsdiabetes und hohe Frühgeburtenrate hinzu. Zudem steigt das Risiko, makrosome Kinder zu gebären. Häufig wird eine Entbindung per Sectio erforderlich.
Präventive Maßnahmen
Eine Gewichtsabnahme vor der Schwangerschaft ist wünschenswert. Vorbestehende Begleiterkrankungen müssen präkonzeptionell erfasst und behandelt werden. Schwangere nach bariatrischen Operationen haben einen signifikant günstigeren Schwangerschaftsverlauf als Frauen mit vergleichbarem BMI vor der Operation. Die Schwangerschaft muss jedoch engmaschig überwacht werden.
Abstract
Background
Obesity in pregnancy is an increasing problem which can be associated with multiple severe obstetrical problems. Women with a desire to become pregnant should be counseled about the adverse effect of obesity on fertility and pregnancy and be encouraged to lose weight before conception.
Risks of obesity on fertility
Risk increases with increasing BMI (body mass index). Fertility is reduced and after successful conception there is a higher risk for spontaneous abortion and congenital malformations. During pregnancy, there is a higher incidence of hypertension, gestational diabetes, and preterm delivery. In addition, the risk for fetal macrosomia increases. Delivery by C-section is often required.
Prevention
Weight loss prior to pregnancy is desired. Preexisting comorbidities must be detected preconceptually and treated. Women who have undergone bariatric surgery have a significantly more favorable outcome than women with comparable BMI before surgery. However, these pregnancies should be closely monitored.
Literatur
Asbjörnsdóttir B, Rasmussen SS, Kelstrup L, Damm P, Mathiesen ER (2014) Impact of restricted maternal weight gain on fetal growth and perinatal morbidity in obese women with type 2 diabetes. JAMA 311(15):1536–1546
Aune D, Saugstad OD, Henriksen T, Tonstad S (2014) Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis. JAMA 16:1536–1546
Bogaerts A, Ameye L, Martens E, Devlieger R (2015) Weight loss in obese pregnant women and risk for adverse perinatal outcomes. Obstet Gynecol 125(3):566–575
Catalano PM, Mele L, Landon MB, Ramin SM, Reddy UM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr, Saade G, Sorokin Y, Peaceman AM, Tolosa JE (2015) Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth? Am J Clin Nutr 101(2):302–309
Chiswick C, Reynolds RM, Denison F (2015) Effect of metformin on maternal and fetal outcomes in obese pregnant women. Lancet Diabetes Endocrinol 3(10):778–786
Cnattingius S, Villamor E, Johansson S, Edstedt Bonamy AK, Persson M, Wikström AK, Granath F (2013) Maternal obesity and risk of preterm delivery. JAMA 309(22):2362–2370
Cohen JM, Hutcheon JA, Kramer MS, Joseph KS, Abenhaim H, Platt RW (2010) Influence of ultrasound-to-delivery interval and maternal-fetal characteristics on validity of estimated fetal weight. Ultrasound Obstet Gynecol 35(4):434–441
Dashe JS, McIntire DD, Twickler DM (2009) Effect of maternal obesity on the ultrasound detection of anomalous fetuses. Obstet Gynecol 113(5):1001–1007
Dietz PM, Callaghan WM, Morrow B, Cogswell ME (2005) Population-based assessment of the risk of primary cesarean delivery due to excess prepregnancy weight among nulliparous women delivering term infants. Matern Child Health J 9(3):237–244
Field NT, Piper JM, Langer O (1995) The effect of maternal obesity on the accuracy of fetal weight estimation. Obstet Gynecol 86(1):102–107
Hendler I, Blackwell SC, Bujold E, Treadwell MC, Wolfe HM, Sokol RJ, Sorokin Y (2004) The impact of maternal obesity on midtrimester sonographic visualization of fetal cardiac and craniospinal structures. Int J Obes Relat Metab Disord 28(12):1607–1611
Heslehurst N, Simpson H, Ells LJ, Rankin J, Wilkinson J, Lang R, Brown TJ, Summerbell CD (2008) The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obes Rev 9(6):635–683. doi:10.1111/j.1467-789X.2008.00511.x
Institut of Medicine (2009) Weight gain during pregnancy. Reexaming the guidelines. The national academic press, Washington DC
Johansson K, Stephansson O, Neovius M (2015) Outcomes of pregnancy after bariatric surgery. N Engl J Med 372(23):2267
Krause KM, Lovelady CA, Østbye T (2011) Predictors of breastfeeding in overweight and obese women: data from Active Mothers Postpartum (AMP). Matern Child Health J 15(3):367–375. doi:10.1007/s10995-010-0667-7
Landres IV, Milki AA, Lathi RB (2010) Karyotype of miscarriages in relation to maternal weight. Hum Reprod 25(5):1123–1126. doi:10.1093/humrep/deq025
Marchi J, Berg M, Dencker A, Olander EK, Begley C (2015) Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews. Obes Rev 16(8):621–638. doi:10.1111/obr.12288
Nohr EA, Bech BH, Davies MJ, Frydenberg M, Henriksen TB, Olsen J (2005) Prepregnancy obesity and fetal death: a study within the Danish National Birth Cohort. Obstet Gynecol 106(2):250–259
Ovesen, Jensen (2012) Übersicht über geburtshilfliche Probleme bei Adipositas
Poston L, Bell R, Croker H (2015) Effect of behavioural intervention in obese pregnantb women (UPBEAT). Lancet Diabetes Endocrinol 3(10):676–776
Ronzoni S, Rosen H, Melamed N, Porat S, Farine D, Maxwell C (2015) Maternal obesity class as a predictor of induction failure: a practical risk assessment tool. Am J Perinatol 32(14):1298–1304. doi:10.1055/s-0035-1563717
Robinson H, Tkatch S (2003) Is maternal obesity a predictor of shoulder dystocia? Obstet Gynecol 101(1):24–27
Stothard KJ, Tennant PW, Bell R, Rankin J (2009) Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301(6):636–650. doi:10.1001/jama.2009.113
Vinter CA, Jensen DM, Ovesen P, Beck-Nielsen H, Jørgensen JS (2011) The LiP (Lifestyle in Pregnancy) study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant women. Diabetes Care 34(12):2502–2507
Vinter CA, Jørgensen JS, Ovesen P, Beck-Nielsen H, Skytthe A, Jensen DM (2014) Metabolic effects of lifestyle intervention in obese pregnant women. Results from the randomized controlled trial “Lifestyle in Pregnancy” (LiP). Diabet Med 31(11):1323–1330
Yu Z, Han S, Zhu J, Sun X, Ji C, Guo X (2013) Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis. PloS One 8(4):e61627–16
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U. Schäfer-Graf erhielt Vortragshonorare von Novo Nordisk, Sanofi und Berlin Chemie.
Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Schäfer-Graf, U. Adipositas und Schwangerschaft. Diabetologe 12, 6–12 (2016). https://doi.org/10.1007/s11428-015-0051-8
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DOI: https://doi.org/10.1007/s11428-015-0051-8