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The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs

  • Clinical Applications of Biomaterials
  • Original Research
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Abstract

The effect of human parathyroid hormone 1–34 (PTH) and simvastatin (SIM) alone could promote bone healing in osteoporotic implant fixation, but there are no reports about the combined use of PTH and SIM for promotion of bone healing around implant in osteoporotic settings. This study aims to investigate effects of PTH + SIM on implant stabilization in osteopenic rats. Fourteen weeks after chronically fed a low protein diet, osteopenic rats randomly received implants. Subsequently, the animals were randomly divided into four groups: Control, SIM, PTH and PTH + SIM. Then all rats from groups PTH, SIM and PTH + SIM received PTH (40 μg/kg, three times a week), SIM (25 mg/kg, daily), or both for 12 weeks. The results of our study indicated that all treatments promoted bone healing around implant compared to Control, but PTH + SIM treatment showed significantly stronger effects than PTH or SIM alone in histological, micro-CT, and biomechanical tests. The results indicated additive effects of PTH and SIM on implant fixation in osteoporotic rats.

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Acknowledgments

This work was funded by a research grant to Zhejiang Provincial Health Department and Chinese Medicine Program (Grant Nos: 2016KYB196, 2016ZA140), Zhejiang Natural Science Foundation (Grant No: LY16H250002).

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People’s Republic of China

    Zhou-Shan Tao, Bing-li Bai, Xian-Bin Yu, Zheng-Liang Huang, Kai-kai Tu, Qiang Zhou, Tao Sun, Hang Li & Lei Yang

  2. Endocrine & Metabolic Diseases Unit, Affiliated Hospital of Guizhou Medical University, Guizhou, 550001, People’s Republic of China

    Wan-Shu Zhou

  3. Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, 325000, Zhejiang, People’s Republic of China

    Yang-Xun Lv

  4. Sichuan Provincial Orthopedics Hospital, No. 132 West First Section First Ring Road, Chengdu, 610000, Sichuan, People’s Republic of China

    Wei Cui

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  1. Zhou-Shan Tao
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Tao, ZS., Zhou, WS., Bai, Bl. et al. The effects of combined human parathyroid hormone (1–34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs. J Mater Sci: Mater Med 27, 43 (2016). https://doi.org/10.1007/s10856-015-5650-9

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