Abstract
The arrhythmic effects of Na+ and Ca2+ intracellular imbalance were examined on rats with aconitine-induced cardiac arrhythmias. Under conditions of Na+-dependent arrhythmogenesis, blockade of Ca2+-channels with verapamil aggravated cardiac rhythm disturbances. Correction of ionic imbalance by intravenous injection of calcium preparations in aconitine-induced arrhythmia promoted recovery of stable sinus rhythm and decreased animal mortality. Intracellular imbalance of Na+ and Ca2+ ions can underlie the arrhythmogenic effects of antiarrhythmic drugs.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 379–381, April, 2006
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Moroz, V.M., Lipnitskii, T.N. Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias. Bull Exp Biol Med 141, 397–399 (2006). https://doi.org/10.1007/s10517-006-0181-5
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DOI: https://doi.org/10.1007/s10517-006-0181-5