Skip to main content
SpringerLink
Log in

An outbreak of Clostridium difficile-associated disease (CDAD) in a German university hospital

  • Brief Report
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bidet P, Lalande V, Salauze B, Burghoffer B, Avesani V, Delmée M, Rossier A, Barbut F, Petit JC (2000) Comparison of PCR-ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile. J Clin Microbiol 38:2484–2487

    PubMed  CAS  Google Scholar 

  2. Clinical and Laboratory Standards Institute (CLSI) (2007) Methods for antimicrobial susceptibility testing of anaerobic bacteria, approved standard—seventh edition. Guidelines of the CLSI: M11–A7. Available online at: http://www.clsi.org/source/orders/free/m11a7.pdf

  3. Barbut F, Mastrantonio P, Delmée M, Brazier J, Kuijper E, Poxton I (2007) Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates. Clin Microbiol Infect 13:1048–1057. doi:10.1111/j.1469-0691.2007.01824.x

    Article  PubMed  CAS  Google Scholar 

  4. Kuijper EJ, Coignard B, Tüll P (2006) Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 12(Suppl 6):2–18. doi:10.1111/j.1469-0691.2006.01580.x

    Article  PubMed  CAS  Google Scholar 

  5. McDonald LC, Coignard B, Dubberke E, Song X, Horan T, Kutty PK (2007) Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 28:140–145. doi:10.1086/511798

    Article  PubMed  Google Scholar 

  6. Robert Koch Institute (2008) Clostridium difficile: current data on severe cases in Germany. Clostridium difficile: Zum Stand der Meldungen schwer verlaufender Infektionen in Deutschland. Epidemolog Bull 15:117–119

    Google Scholar 

  7. Gaynes R, Rimland D, Killum E, Lowery HK, Johnson TM 2nd, Killgore G, Tenover FC (2004) Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin Infect Dis 38:640–645. doi:10.1086/381551

    Article  PubMed  Google Scholar 

  8. Dubberke ER, Reske KA, Yan Y, Olsen MA, McDonald LC, Fraser VJ (2007) Clostridium difficile-associated disease in a setting of endemicity: identification of novel risk factors. Clin Infect Dis 45:1543–1549. doi:10.1086/523582

    Article  PubMed  Google Scholar 

  9. Carignan A, Allard C, Pépin J, Cossette B, Nault V, Valiquette L (2008) Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Clin Infect Dis 46:1838–1843. doi:10.1086/588291

    Article  PubMed  Google Scholar 

  10. Vonberg RP, Kuijper EJ, Wilcox MH, Barbut F, Tüll P, Gastmeier P; European C Difficile-Infection Control Group (2008) Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect 14(Suppl.5):2–20. doi:10.1111/j.1469-0691.2008.01992.x

    Article  PubMed  Google Scholar 

  11. Kleinkauf N, Weiss B, Jansen A, Eckmanns T, Bornhofen B, Küehnen E, Weil HP, Michels H (2007) Confirmed cases and report of clusters of severe infections due to Clostridium difficile PCR ribotype 027 in Germany. Euro Surveill 12:E071115.2

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank Edward J. Kuijper from the Leiden University Medical Centre, Leiden, The Netherlands, for providing us with the CD strain ribotype 027 that served as a positive control. We would also like to thank Manfred Kist from Freiburg University Hospital, Germany, for his assistance in the ribotyping.

Author information

Authors and Affiliations

  1. Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    K. Graf, A. Cohrs, P. Gastmeier, A. Kola, R.-P. Vonberg, F. Mattner & I. F. Chaberny

  2. Institute of Hygiene and Environmental Medicine, Charité—University Medicine Berlin, Berlin, Germany

    D. Sohr

  3. Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany

    F. Mattner

Authors
  1. K. Graf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Cohrs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Gastmeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Kola
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R.-P. Vonberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. Mattner
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. Sohr
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. I. F. Chaberny
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Graf.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graf, K., Cohrs, A., Gastmeier, P. et al. An outbreak of Clostridium difficile-associated disease (CDAD) in a German university hospital. Eur J Clin Microbiol Infect Dis 28, 543–545 (2009). https://doi.org/10.1007/s10096-008-0655-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-008-0655-7

Keywords

Search

Navigation