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Wine and bone health: a review

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Abstract

A light-to-moderate wine consumption has been shown to provide several beneficial effects on the skeletal system, including reduced risk of bone mass loss and fractures. Wine is rich in phenolic compounds, strong phytoestrogens and natural antioxidants, to which bone protection is mainly attributed. The objective of this review was to give an overview of the exact mechanisms by which wine consumption is involved in bone protection. We found a great variety of in vitro research on the beneficial effects of isolated wine phenolics on the skeletal system, with a significant lack of evidence of their in vivo effects. In addition, we found almost no studies investigating how wine, a mixture of these phenolics dissolved in ethanol, affects the skeletal system. Our results warrant further research on this interesting topic.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Orthopedic Clinic, Clinical Hospital Centre Split, Split, Croatia

    Zvonimir Kutleša

  2. Department of Diagnostic and Interventional Radiology, University Hospital Split, Spinciceva 1, 21000, Split, Croatia

    Danijela Budimir Mršić

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  1. Zvonimir Kutleša
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  2. Danijela Budimir Mršić
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Correspondence to Danijela Budimir Mršić.

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Kutleša, Z., Budimir Mršić, D. Wine and bone health: a review. J Bone Miner Metab 34, 11–22 (2016). https://doi.org/10.1007/s00774-015-0660-8

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