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Management options for established chemotherapy-induced peripheral neuropathy

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a variety of chemotherapeutic agents. Clinicians are cognizant of the negative impact of CIPN on cancer treatment outcomes and patients’ psychosocial functioning and quality of life. In an attempt to alleviate this problem, clinicians and patients try various therapeutic interventions, despite limited evidence to support efficacy of these treatments. The rationale for such use is mostly based on the evidence for the treatment options in non-CIPN peripheral neuropathy syndromes, as this area is more robustly studied than is CIPN treatment. In this manuscript, we examine the existing evidence for both CIPN and non-CIPN treatments and develop a summary of the best available evidence with the aim of developing a practical approach to the treatment of CIPN, based on available literature and clinical practice experience.

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Conflict of interest

The authors do not have a financial relationship with the organization that sponsored the research. All author disclosures are included in the attached author disclosure forms. This is a review article, and the primary author has full control of all primary data and agrees to allow the journal to review data if requested.

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Authors and Affiliations

  1. Division of Medical Oncology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA

    Deirdre R. Pachman & Charles L. Loprinzi

  2. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    James C. Watson

  3. Division of Medical Oncology, Stephanie Spielman Comprehensive Breast Center, The Arthur G. James Cancer Hospital at the Ohio State University, Columbus, OH, USA

    Maryam B. Lustberg

  4. Division of Medical Oncology, Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA

    Nina D. Wagner-Johnston

  5. Department of Pharmacy, National University of Singapore, Singapore, Singapore

    Alexandre Chan & Yin Ting Cheung

  6. Department of Pharmacy, Cancer Care Nova Scotia, Halifax, Nova Scotia, Canada

    Larry Broadfield

  7. Border Medical Oncology, Wodonga, Australia

    Christopher Steer

  8. Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK

    Dawn J. Storey

  9. Department of Radiation Oncology, James P.Wilmot Cancer Center, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA

    Kavita D. Chandwani

  10. Cancer Pain Program, Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Judith Paice

  11. Department of Psychology, Neurocognitive Translational Research Lab, Biobehavioral Oncology Research Program, University of Notre Dame, Notre Dame, IN, USA

    Pascal Jean-Pierre

  12. Center for Lasting Effects of Cancer Treatment, Department of General Internal Medicine, MD Anderson Cancer Center, Houston, TX, USA

    Jeong Oh

  13. Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA

    Jayesh Kamath

  14. University of Edinburgh, Edinburgh, UK

    Marie Fallon

  15. Department of Neurology, University of Marburg, Baldinger Strasse, Marburg, Germany

    Herwig Strik

  16. Department of Neurology, University of Duisburg-Essen, Essen, Germany

    Susanne Koeppen

Authors
  1. Deirdre R. Pachman
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  2. James C. Watson
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  3. Maryam B. Lustberg
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  4. Nina D. Wagner-Johnston
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  5. Alexandre Chan
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  9. Dawn J. Storey
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  11. Judith Paice
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  12. Pascal Jean-Pierre
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  13. Jeong Oh
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  14. Jayesh Kamath
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  15. Marie Fallon
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  16. Herwig Strik
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  17. Susanne Koeppen
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  18. Charles L. Loprinzi
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Corresponding author

Correspondence to Deirdre R. Pachman.

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This manuscript is a product from the MASCC Neurologic Complications Study Group

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Pachman, D.R., Watson, J.C., Lustberg, M.B. et al. Management options for established chemotherapy-induced peripheral neuropathy. Support Care Cancer 22, 2281–2295 (2014). https://doi.org/10.1007/s00520-014-2289-x

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  • DOI: https://doi.org/10.1007/s00520-014-2289-x

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