Abstract
Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952–2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.
Similar content being viewed by others
References
Addimanda O, Mancarella L, Dolzani P et al (2012) Clinical associations in patients with osteoarthritis. Scand J Rheumatol 41:310–313
Altman RD (2010) Pharmacological therapies for osteoarthritis of the hand: a review of the evidence. Drugs Aging 27:729–745
Altman RD, Dreiser RL, Fisher CL et al (2009) Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial. J Rheumatol 36:1991–1999
Ardiç F, Ozgen M, Aybek H, Rota S, Cubukçu D, Gökgöz A (2007) Effects of balneotherapy on serum IL-1, PGE2 and LTB4 levels in fibromyalgia patients. Rheumatol Int 27:441–446
Bellamy N, Campbell J, Haraoui B, Buchbinder et al (2002) Dimensionality and clinical importance of pain and disability in hand osteoarthritis: development of the Australian/Canadian (AUSCAN) osteoarthritis hand index. Osteoarthritis Cartilag 10:855–862
Bellometti S, Galzigna L (1998) Serum levels of a prostaglandin and a leukotriene after thermal mud pack therapy. J Investig Med 46:140–145
Bellometti S, Galzigna L, Richelmi P, Gregotti C, Bertè F (2002) Both serum receptors of tumor necrosis factor are influenced by mud pack treatment in osteoarthrotic patients. Int J Tissue React 24:57–64
Bender T, Karagülle Z, Bálint GP et al (2005) Hydrotherapy, balneotherapy, and spa treatment in pain management. Rheumatol Int 25:220–224
Bender T, Bariska J, Vàghy R et al (2007) Effect of balneotherapy on the Antoxidant System – A controlled pilot study. Arch Med Res 38:86–89
Braga PC, Sambataro G, Dal Sasso M et al (2008) Antioxidant effect of sulphurous thermal water on human neutrophil bursts: chemiluminescence evaluation. Respiration 75:193–201
Bresalier RS, Sandler RS, Quan H et al (2005) Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial investigators Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 352:1092–1102
Britschka ZMN, Teodoro WR, Velosa APP, de Mello SB (2007) The effect of Brazilian black mud treatment in chronic experimental arthritis. Rheumatol Int 28:39–45
Burguera EF, Vela-Anero A, Magalhães J et al (2014) Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes. Osteoarthritis Cartilag 22:1026–1035
Cecchettin M, Bellometti S, Lalli A et al (1995) Serum interleukin 1 changes in artrhosic patients after mud-packs treatment. Phys Rheab Kur Med 5:92–93
Cozzi F, Carrara M, Sfriso P et al (2004) Anti-inflammatory effect of mud-bath applications on adjuvant arthritis in rats. Clin Exp Rheumatol 22:763–766
Dahaghin S, Bierma-Zeinstra SM, Ginai AZ et al (2005) Prevalence and pattern of radiographic hand osteoarthritis and associations with pain and disability (The Rotterdam study). Ann Rheum Dis 64:682–687
Dreiser RL, Maheu E, Guillou GB (2000) Sensitivity to change of the functional index for hand osteoarthritis. Osteoarthritis Cartilag 8(Suppl A):S25–S28
EuroQol Group (1990) EuroQol: a new facility for the measurement of health related quality of life. Health Policy 16:199–208
Fioravanti A, Valenti M, Altobelli E et al (2003) Clinical efficacy and cost-effectiveness evidence of spa therapy in osteoarthritis. The results of "Naiade" Italian Project. Panminerva Med 45:211–217
Fioravanti A, Cantarini L, Bacarelli MR et al (2011a) Effects of spa therapy on serum leptin and adiponectin levels in patients with knee osteoarthritis. Rheumatol Int 31:879–882
Fioravanti A, Cantarini L, Guidelli GM, Galeazzi M (2011b) Mechanisms of action of spa therapies in rheumatic diseases: what scientific evidence is there? Rheumatol Int 31:1–8
Fioravanti A, Giannitti C, Bellisai B et al (2011c) Efficacy of balneotherapy on pain, function and quality of life in patients with osteoarthritis of the knee. Int J Biometeorol 56:583–590
Fioravanti A, Lamboglia A, Pascarelli NA et al (2013) Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin 1β on nitric oxide production and apoptosis in human osteoarthritic chondrocytes. J Biol Regul Homeost Agents 27:891–902
Fioravanti A, Bacaro G, Giannitti C, et al (2014) One-year follow-up of mud-bath therapy in patients with bilateral knee osteoarthritis: a randomized, single-blind controlled trial. Int J Biometeorol Dec17 [Epub ahead of print]
Fioravanti A, Tenti S, Giannitti C et al (2014b) Short- and long-term effects of mud-bath treatment on hand osteoarthritis: a randomized clinical trial. Int J Biometeorol 58:79–86
Fioravanti A, Giannitti C, Cheleschi S, et al (2015) Circulating levels of adiponectin, resistin, and visfatin after mud-bath therapy in patients with bilateral knee osteoarthritis. Int J Biometeorol Mar 7 [Epub ahead of print]
Forestier R, Desfour H, Tessier JM et al (2010) Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial. Ann Rheum Dis 69:660–665
Fox B, Schantz JT, Haigh R et al (2012) Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint? J Cell Mol Med 16:896–910
Francin PJ, Abot A, Guillaume C et al (2014) Association between adiponectin and cartilage degradation in human osteoarthritis. Osteoarthritis Cartilag 22:519–526
Fries JF, Spitz PW, Kraines RG, Holman HR (1980) Measurement of patient outcome in arthritis. Arthritis Rheum 23:137–145
Gabay C, Medinger-Sadowski C, Gascon D et al (2011) A Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum 63:3383–3391
Gandini F, Giannitti C, Fattore G et al (2012) Validation of an Italian version of the functional index for hand osteoarthritis (FIHOA). Mod Rheumatol 22:758–765
Guidelli GM, Tenti S, De Nobili E, Fioravanti A (2012) Fibromyalgia syndrome and spa therapy: myth or reality? Clin Med Insights Arthritis Musculoskelet Disord 5:19–26
Gutenbrunner C, Bender T, Cantista P et al (2010) A proposal for a worldwide definition of health resort medicine, balneology, medical hydrology and climatology. Int J Biometeorol 54:495–507
Horváth K, Kulisch Á, Németh A, Bender T (2012) Evaluation of the effect of balneotherapy in patients with osteoarthritis of the hands: a randomized controlled single-blind follow-up study. Clin Rehabil 26:431–441
Kearney PM, Baigent C, Godwin J et al (2006) Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 332:1302–1308
Kloesch B, Liszt M, Steiner G, Brӧll J (2012) Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1β-induced IL-6 amd IL-8 expression in the human chondrocyte cell line C-28/I2. Rheumatol Int 32:729–736
Koskinen A, Juslin S, Nieminen R et al (2011) Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen activated protein kinase pathways. Arthritis Res Ther 13:R184
Koskinen A, Vuolteenaho K, Moilanen T, Moilanen E (2014) Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3. Scand J Rheumatol 43:249–253
Kovács C, Pecze M, Tihanyi A et al (2012) The effect of sulphurous water in patients with osteoarthritis of hand. Double-blind, randomized, controlled follow-up study. Clin Rheumatol 31:1437–1442
Kubota K, Kurabayashi H, Tamura K et al (1992) A transient rise in plasma beta-endorphin after a traditional 47 degrees C hot-spring bath in Kusatsu-spa, Japan. Life Sci 51:1877–1880
Kuczera M, Kokot F (1996) Effect of spa therapy on the endocrine system. I. Stress reaction hormones. Pol Arch Med Wewn 95:11–20
Kulisch Á, Benkö Á, Bergmann A et al (2014) Evaluation of the effect of Lake Hévíz thermal mineral water in patients with osteoarthritis of the knee: a randomized, controlled, single-blind, follow-up study. Eur J Phys Rehabil Med 50:373–381
Li L, Fox B, Keeble J, Salto-Tellez M et al (2013) The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med 17:365–376
Mahendira D, Towheed TE (2009) Systematic review of non-surgical therapies for osteoarthritis of the hand: an update. Osteoarthritis Cartilag 17:1263–1268
Massengale M, Lu B, Pan JJ et al (2012) Adipokine hormones and hand osteoarthritis: radiographic severity and pain. PLoS One 7, e47860
Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150:971–979
Oliveria SA, Felson DT, Reed JI et al (1995) AM Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 38:1134–1141
Presle N, Pottie P, Dumond H et al (2006) Differential distribution of adipokines between plasma and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilag 14:690–695
Senolt L, Housa D, Vernerova Z et al (2007) Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 66:458–463
Steppan CM, Bailey ST, Bhat S et al (2001) The hormone resistin links obesity to diabetes. Nature 409:307–312
Sukenik S, Flusser D, Abu-Shakra M (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin North Am 25:883–897
Tenti S, Cheleschi S, Galeazzi M et al (2014) Spa therapy: can be a valid option for treating knee osteoarthritis? Int J Biometeorol Oct 23 [Epub ahead of print]
Verhagen AP, de Vet HC, de Bie RA et al (2000) Balneotherapy for rheumatoid arthritis and osteoarthritis. Cochrane Database Syst Rev 2, CD000518
Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483
Yusuf E, Nelissen RG, Ioan-Facsinay A et al (2010) Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis 69:761–765
Zhang Y, Jordan JM (2010) Epidemiology of osteoarthritis. Clin Geriatr Med 26:355–369
Zhang Y, Niu J, Kelly-Hayes M et al (2002) Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study. Am J Epidemiol 56:1021–1027
Zhang W, Doherty M, Leeb BF et al (2007) EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 66:377–388
Conflict of interest
The authors declare that they have no conflict of interest.
Authors' contribution
All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version to be published.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fortunati, N.A., Fioravanti, A., Seri, G. et al. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action. Int J Biometeorol 60, 1–8 (2016). https://doi.org/10.1007/s00484-015-1030-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00484-015-1030-x