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Implications of maternal conditions and pregnancy course on offspring’s medical problems in adult life

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Abstract

In the last decade, numerous epidemiological, clinical and experimental data show that periconceptional, perinatal and postnatal environment determines the offspring’s risk for later-life chronic disease. For this phenomenon, the term “fetal” or “perinatal programming” is used. In exposed offspring already in childhood and early adulthood, metabolic and cardiovascular changes can be observed, leading to obesity, diabetes and hypertension. Nowadays, the mode of conception (e.g., in vitro fertilization), maternal metabolic conditions (e.g., undernutrition, overnutrition, diabetes) and complications during pregnancy (e.g., preeclampsia, intrauterine growth restriction) are suspected to be negative predictors for offspring’s long-term health. Mechanisms responsible for these effects still remain mainly unclear, but include epigenetic, transcriptional, endoplasmic reticulum stress, and reactive oxygen species. This review presents a piece of the puzzle with regards to periconceptional and early perinatal conditions determining later-life risk for chronic adult disease.

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  1. Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Julia von Ehr & Frauke von Versen-Höynck

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  1. Julia von Ehr
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  2. Frauke von Versen-Höynck
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Correspondence to Frauke von Versen-Höynck.

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von Ehr, J., von Versen-Höynck, F. Implications of maternal conditions and pregnancy course on offspring’s medical problems in adult life. Arch Gynecol Obstet 294, 673–679 (2016). https://doi.org/10.1007/s00404-016-4178-7

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