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Sjögren-Syndrom

Sjögren’s syndrome

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Zusammenfassung

Das Sjögren-Syndrom ist eine Autoimmunerkrankung mit lymphozytärer Infiltration der Tränen- und Speicheldrüsen und führt zu Mund- und Augentrockenheit. In der Diagnostik des Sjögren-Syndroms sollte auf extraglanduläre Manifestationen, wie z. B. Polyneuropathie, Arthritis oder gehäufte Atemwegsinfekte, geachtet, die Tränen- und Speichelproduktion gemessen, Antikörper gegen SS-A und SS-B bestimmt und ggf. eine Speicheldrüsenbiopsie durchgeführt werden. Die Behandlung der Mund- und Augentrockenheit erfolgt rein symptomatisch, die der extraglandulären Manifestationen orientiert sich an den entsprechenden Organmanifestationen des systemischen Lupus erythematodes.

Abstract

Sjögren’s syndrome is an autoimmune disease characterized by lymphocytic infiltration of the tear and salivary glands leading to dryness of the mouth and eyes. The awareness that extraglandular manifestations, such as polyneuropathy, arthritis or recurrent airway infections may indicate Sjögren’s syndrome is important. In the diagnostic procedure, the tear and saliva production and antibodies against Sjögren’s syndrome A (SS-A) and SS-B should be measured. A salivary gland biopsy should be performed when the diagnosis is not still clear. The therapy of oral and ocular dryness is mainly symptomatic whereas the treatment of extraglandular manifestations is based on experience with treatment of these manifestations in systemic lupus erythematosus (SLE).

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Einhaltung ethischer Richtlinien

Interessenkonflikt. Torsten Witte: Referententätigkeit für die Firmen Roche Pharma AG, AbbVie Deutschland GmbH, GlaxoSmithKline GmbH & Co KG, Chugai Pharma Marketing Ltd, MSD, Sharpe Dohme GmbH, Novartis Pharma GmbH, Pfizer Pharma GmbH, UCB Pharma GmbH. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Witte, T. Sjögren-Syndrom. Z. Rheumatol. 73, 49–61 (2014). https://doi.org/10.1007/s00393-013-1313-8

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  • DOI: https://doi.org/10.1007/s00393-013-1313-8

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