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Systemischer Lupus erythematodes

Systemic lupus erythematosus

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Zusammenfassung

Der systemische Lupus erythematodes (SLE) ist die klassische systemische Autoimmunerkrankung. Die Prävalenz liegt in Europa bei Frauen etwas unter 1:1000, bei Männern eine Zehnerpotenz niedriger. Typischerweise tritt die Erkrankung bei Patientinnen im gebärfähigen Alter auf. Während der schwere SLE unbehandelt eine regelhaft tödliche Erkrankung war, hat sich die Prognose schrittweise durch Glukokortikoide, Immunsuppressiva und schließlich innovative Behandlungsverfahren dramatisch verbessert. Direkt durch den SLE verursachte Todesfälle sind heute selten, wenn auch Infektionen, Thrombosen und beschleunigte Arteriosklerose signifikante Probleme darstellen. Diese Übersichtsarbeit hat das Ziel, den heutigen Stand des Managements von Lupuspatienten darzustellen.

Abstract

Systemic lupus erythematosus (SLE) is the classical systemic autoimmune disease. Its prevalence is slightly below 1:1,000 in women and 10-fold lower in men. Typically, the disease manifests in women of childbearing age. While severe untreated SLE used to be a fatal disease, prognosis has improved stepwise with corticosteroids, cyclophosphamide and novel therapies. Deaths directly related to SLE are uncommon nowadays but infections, thromboses and accelerated atherosclerosis cause significant problems. The current review presents the state of the art in managing SLE patients.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Roche, GSK (Advisory Boards), Centocor (Grant).

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Correspondence to M. Aringer.

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Aringer, M., Hiepe, F. Systemischer Lupus erythematodes. Z. Rheumatol. 70, 313–323 (2011). https://doi.org/10.1007/s00393-011-0794-6

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