Zusammenfassung
Die rheumatoide Arthritis ist eine Erkrankung mit dauerhaftem und zerstörerischem Charakter. Für die Patienten entsteht mitunter eine enorme Funktionseinbuße. Das ultimative Ziel der Therapie ist die Remission der Krankheitsaktivität, ein Terminus der jedoch höchst variabel definiert wird, sodass die resultierenden Zustände sehr heterogen sind. Gleichermaßen heterogen sind demnach auch die Erfolge in der Prävention des Fortschreitens der strukturellen und funktionellen Veränderungen. Stringente Definitionen von Remission sind deshalb zu fordern. Standardisierte intensivierte therapeutische Strategien und Algorithmen sollten die Basis des Einsatzes von antirheumatischen Medikamenten darstellen.
Abstract
Rheumatoid arthritis is a chronic disabling disease that results in considerable loss of physical function in patients over time. The ultimate goal of therapy is remission, a clinical state with a highly variable definition in the literature. For the purpose of achieving the best patient outcome, it is important to maintain the lowest possible disease activity. Therefore, stringent remission criteria should be chosen, which will lead to the best possible prevention of structural and functional decline. Standardised intensive therapeutic strategies and algorithms should form the basis for the administration of anti-rheumatic medication.
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Aletaha, D., Smolen, J. Rheumatoide Arthritis. Z. Rheumatol. 68, 10–15 (2009). https://doi.org/10.1007/s00393-008-0357-7
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DOI: https://doi.org/10.1007/s00393-008-0357-7