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Die Zervikale Myelopathie als Komplikation der Rheumatoiden Arthritis

Cervical myelopathy in rheumatoid arthritis

  • BEITRAG ZUM SCHWERPUNKTTHEMA
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Zusammenfassung.

Die Arthritis der Halswirbelsäule mit Instabilität im Atlantodentalgelenk und Spinalkanalstenose stellt eine typische und häufige Komplikation der Rheumatoiden Arthritis dar. Die Zervikale Myelopathie ist ein seltene aber schwerwiegende Folge dieser Manifestation. Es besteht keine strenge Korrelation zwischen dem Ausmaß der Halswirbelsäulenveränderungen und dem Auftreten einer Myelopathie. Die Diagnose der Zervikalen Myelopathie wird durch die meistens parallel bestehenden erheblichen peripheren Gelenkveränderungen mit Beeinträchtigung der Bewegungsorgane erschwert. Die Therapieentscheidung konservativ versus operativ erfordert neben subtiler klinischer, neurophysiologischer und radiologischer Diagnostik vor allem eine möglichst genaue Erfassung der Verlaufsdynamik der Rheumatoiden Arthritis und der Zervikalen Myelopathie. Voraussetzung ist eine enge Kooperation zwischen Rheumatologen, Rheumachirurgen und Neurologen.

Summary.

Arthritis of the cervical spine with instability of the atlantodental joint is a typical and frequent complicaiton in rheumatoid arthritis. Subsequent cervical myelopathy is rare but usually a severe complication. There is no stringent correlation between arthritis of cervical spine an occurrence of cervical myelopathy. Cervical myelopathy is often difficult to discern from parallel multilating peripheral joint damage, which makes the diagnosis difficult. The decision between conservative and operative therapeutic intervention has to be based on subtle clinical, neurophysiological and radiological assessment and—in particular—requires exact analysis of the course of the underlying rheumatoid arthritis and myelopathy. In this diagnostic process close collaboration of rheumatologist, surgeon and neurologist is essential.

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References

  1. Albrecht HJ, Huber H, Leib F, Westerburg W (1997) Internistische Aspekte zur Operationsindikation an der HWS Akt. Rheumatol. 12:99–103

    Google Scholar 

  2. van Asselt KM, Lems WF, Bongartz EB, Hamburger HL, Drossaers-Bakker KW, Dijkmans BAC, van Soesbergen RM (2001) Outcome of Cervical Spine Surgery in Patients with Rheumatoid Arthritis. Ann Rheum Dis 60:448–452

    Article  CAS  PubMed  Google Scholar 

  3. Bednarik J, Kandanka Z, Vohanka S, Stejskal L, Vlach O, Schroder R (1999) The Value of Somatosensory and Motor Evoked Potentials in Predicting and Monitoring the Effect of Therapy in Spondylotic Cervical Myelopathy. A Prospective Randomised Study. Spine 24:1593–1598

    Article  CAS  PubMed  Google Scholar 

  4. Bland JH, Eddy WM (1968) Hemiplegia and Rheumatoid Hemiarthritis. Arthritis Rheum 11:72–80

    CAS  PubMed  Google Scholar 

  5. Blankenship LD, Basford JR, Strommen JA, Andersen RJ (2002) Hypoglossal Nerve Palsy from Cervical Spine Involvement in Rheumatoid Arthritis: 3 Case Report. Arch. Phys. Med. Rehabil. 83(2):269–272

    Article  PubMed  Google Scholar 

  6. Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Wiesel S (1990) Abnormal Magnetic-Resonance Scans of the Cervical Spine in Asymptomatic Subjects. J Bone Joint Surg Am 72:1178–1184

    CAS  PubMed  Google Scholar 

  7. Boden SD, Dodge LD, Bohlman HH, Rechtine GR (1993) Rheumatoid Arthritis of the Cervical Spine. A Long Term Analysis with Predictors of Paralysis and Recovery. J Bone Joint Surg Am 75:1282–1297

    CAS  PubMed  Google Scholar 

  8. Boden SD (1994) Rheumatoid Arthritis of the Cervical Spine. Surgical Decision Making Based on Predictors of Paralysis and Recovery. Spine 19:2275–2280

    CAS  PubMed  Google Scholar 

  9. Bonica JJ, Sola AE (1990) Neck Pain. In: Bonica JJ (ed) The Management of Pain. Lea & Febiger Philadelphia London, pp 848–867

  10. Bouchard JA, Bohlman HH, Biro C (1996) Intraoperative Improvements of Somatosensory Evoked Potentials: Correlation to Clinical Outcome in Surgery for Cervical Spondylotic Myelopathy. Spine 21:589–594

    Article  CAS  PubMed  Google Scholar 

  11. Bouchaud-Chabot A, Liote F (2002) Cervical Spine Involvement in Rheumatoid Arthritis. A Review. Joint Bone Spine 69:141–154

    Article  PubMed  Google Scholar 

  12. Boyce RH, Wang JC (2003) Evaluation of Neck Pain Radiculopathy and Myelopathy: Imaging Conservative Treatment and Surgical Indications. Instr. Course Lect. 52:489–495

    PubMed  Google Scholar 

  13. Brain WR, Knight GC, Bull JWD (1948) Discussion on Rupture of Intervertebral Disc in Cervical Region. Proc Roy Soc Med 41:509

    Google Scholar 

  14. Brain WR, Northfield D, Wilkinson M (2952) Neurological Manifestations of Cervical Spondylosis. Brain 75:187–225

    Google Scholar 

  15. Breig A, el-Nadi AF (1966) Biomechanics of the Cervical Spinal Cord: Relief of Contact Pressure on an Overstretching of the Spinal Cord. Acta Radiol Diagn 4:602–624

    CAS  Google Scholar 

  16. Breig A, Turnbull I, Hassler O (1966) Effects of Mechanical Stresses on the Spinal Cord in Cervical Spondylosis: A Study on Fresh Cadaver Material. J Neurosurg 25:45–56

    CAS  PubMed  Google Scholar 

  17. Brunholzl C, Claus D (1994) Central Motor Conduction Time to Upper and Lower Limbs in Cervical Cord Lesions. Arch Neurol 51:245–249

    CAS  PubMed  Google Scholar 

  18. Cabot A, Becker A (1978) The Cervical Spine in Rheumatoid Arthritis. Clin Orthop Rel Res 131:130–140

    Google Scholar 

  19. Casey AT, Crockard HA, Bland M, Stevens J, Moskovich R, Ransford AO (1996) Surgery on the Rheumatoid Cervical Spine for the Non-Ambulant Myelopathic Patient—Too much, Too Late? Lancet 347:1004–1007

    Article  CAS  PubMed  Google Scholar 

  20. Casey AT, Crockard HA, Geddes JF, Stevens J (1997) Vertical Translocation: The Enigma of the Disappearing Atlantodens Interval in Patients with Myelopathy and Rheumatoid Arthritis: Clinical, Radiological, and Neuropathological Features. J Neurosurg 87:856–862

    CAS  PubMed  Google Scholar 

  21. Casey AT, Crockard HA, Stevens J (1997) Vertical Translocation: Outcomes after Surgical Treatment of Rheumatoid Cervical Myelopathy. J Neurosurg 87:863–869

    CAS  PubMed  Google Scholar 

  22. Castillo M, Arbelaez A, Fisher LL, Smith JK, Mukherji SK (1999) Diffusion Weighted Imaging in Patients with Cervical Spondylosis. Int J Neuroradiol 5:79–85

    Google Scholar 

  23. Chevalier X, Larget-Piet B (1994) General Disease of the Spine in Rheumatoid Arthritis. Curr Opin Rheumatol 6:311–318

    CAS  PubMed  Google Scholar 

  24. Conlon PW, Isdale IC, Rose BS (1966) Rheumatoid Arthritis of the Cervical Spine—An Analysis of 333 Cases. Ann Rheum Dis 25:120–126

    CAS  PubMed  Google Scholar 

  25. DaSilva E, Doran MF, Crowson CS, O’Fallon WM, Matteson EL (2003) Declining Use of Orthopedic Surgery in Patients with Rheumatoid Arthritis? Results of a Long-Term, Population-Based Assessment. Arthritis Rheum 49:216–220

    Article  PubMed  Google Scholar 

  26. Davis FW, Markley MI (1954) Rheumatoid Arthritis with Death from Medullary Compression. Ann Intern Med 35:451

    Google Scholar 

  27. Delamarter RB, Bohlman HH (1994) Postmortem Osseous and Neuropathological Analysis of Rheumatoid Cervical Spine. Spine 19:2267–2274

    CAS  PubMed  Google Scholar 

  28. Demir A, Ries M, Moonen CT, Vital JM, Dehais J, Arne P, Caille JM, Dousset V (2003) Diffusion-Weighed MR Imaging with Apparent Diffusion Coefficient an Apparent Diffusion Tensor Maps in Cervical Spondylotic Myelopathy. Radiology Oct 229(1):37–43

    Google Scholar 

  29. Dennis GC, Dehkordi O, Millis RM, Said B, Baganz MD (2000) Somatosensory Evoked Potential, Neurological Examination and Magnetic Resonance Imaging Potential, Neurological Assessment of Cervical Spinal Cord Decompression. Life Sci 66:389–397

    Article  CAS  PubMed  Google Scholar 

  30. Dorfman LJ, Perkash I, Bosley TM, Cummins KL (1980) Use of Cerebral Evoked Potentials to Evaluate Spinal Somatosensory Function in Patients with Traumatic and Surgical Myelopathies. J Neurosurg 52:654–660

    CAS  PubMed  Google Scholar 

  31. Edmeads J (1988) The Cervical Spine and Headache. Neurology 38:1874–1878

    CAS  PubMed  Google Scholar 

  32. Elsberg CA (1945) The Anatomy and Surgery of the Edwin Smith Surgical Papyrus. J Mt Sinai Hoop 12:141–151

    Google Scholar 

  33. Emery SE (2001) Cervical Spondylotic Myelopathy: Diagnosis and Treatment. J Am Acad Orthop Surg 9:376–388

    CAS  PubMed  Google Scholar 

  34. Engsberg JR, Lauryssen C, Ross SA, Hollman JH, Walker D, Wippold II (2003) Spasticity, Strength, and Gait Changes after Surgery for Cervic Spondylotic Myelopathy: A Case Report. Spine 28:136–139

    Article  Google Scholar 

  35. Eyres KS, Gray DH, Robertson P (1998) Posterior Surgical Treatment for Rheumatoid Cervical Spine. Br J Rheumatol 37:756–759

    Article  CAS  PubMed  Google Scholar 

  36. Falope ZF, Griffiths ID, Platt PN, Todd NV (2002) Cervical Myelopathy and Rheumatoid Arthritis: A Retrospective Analysis of Management. Clin Rehabil 16(6):625–629

    Article  CAS  PubMed  Google Scholar 

  37. Fielding JW (1983) In: Evarts CM (ed) Rheumatoid Arthritis of the Cervival Spine. AAOS Instructional Course Lectures. Mosby, St Lous 32:114–131

    CAS  Google Scholar 

  38. Fujiwara K, Yonenobu K, Ebara S, Yamashita K, OnoK (1989) The Prognosis of Surgery for Cervical Compression Myelopathy. J Bone Joint Surg Br 71:393–398

    CAS  PubMed  Google Scholar 

  39. Fujiwara K, Fujimoto M, Owaki H, Kono J, Nakase T, Yonenobu K, Ochi T (1998) Cervical Lesions Related to the Systemic Progression in Rheumtoid Arthritis. Spine 23:2052–2056

    Article  CAS  PubMed  Google Scholar 

  40. Garrod AE (1890) A Treatise on Rheumatism and Rheumatoid Arthritis. Griffin, London

  41. Gullotta F (1991) Neuropathologische Befunde bei zervikalen Myelopathien. Die Wirbelsäule in Forschung und Praxis 113:21–24

    Google Scholar 

  42. Grob D (1993) Principles of Surgical Treatment of the Cervical Spine in Rheumatoid Arthritis. Eur Spine J 2:180–190

    Google Scholar 

  43. Grob D, Wursch R, Grauer W, Sturzenegger J, Dvorak J (1997) Atlantoaxial Fusion and Retrodental Pannus in Rheumatoid Arthritis. Spine 22:1580–1583

    Article  CAS  PubMed  Google Scholar 

  44. Hagena F-W, Krödel A (1991) Zervikale Instabilität und Myelopathie bei chronischer Polyarthritis. Die Wirbelsäule in Forschung und Praxis 113:86–96

    Google Scholar 

  45. Hamilton JD, Johnston RA, Madhok R, Capell HA (2001) Factors Predictive of Subsequent Detoriation in Rheumatoid Cervical Myelopathy. Rheumatology 40:811–815

    Article  CAS  PubMed  Google Scholar 

  46. Hasegawa K, Homma T, Chiba Y, Hirano T, Watanabe K, Yamazaki A (2002) Effects of Surgical Treatment for Cervical Spondylotic Myelopathy in Patients > or=70 Years of Age: A Retrospective Comparative Study. J Spinal Disord Tech 15(6):458–460

    PubMed  Google Scholar 

  47. Hashimoto T, Uozumi T, Tsuji S (2000) Paraspinal Motor Evoked Potentials by Magnetic Stimulation of the Motor Cortex. Neurology 55:885–888

    CAS  PubMed  Google Scholar 

  48. Heiskari M, Siivola J, Heikinen ER (1986) Somatosensory Evoked Potentials in Evaluation of Decompressive Suregery of Cervical Spondylosis and Herniated Disc Ann Clin Res 18:107–113

    PubMed  Google Scholar 

  49. Hughes JT (1977) Spinal Cord Involvement by C4-C5 Vertebral Subluxation in Rheumatoid Arthritis: A Description of Two Cases Examined at Necropsy. Ann Neurol 1:575–582

    CAS  PubMed  Google Scholar 

  50. Hughes JT (1948) Disorders of the Spine and Spinal Cord. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield’s Neuropathology 4th. Arnold London

  51. Isdale IC, Conlon PW (1971) Atlanto-Axial Subluxation: A Six Year Follow-Up Report. Ann Rheum Dis 30:387–389

    CAS  PubMed  Google Scholar 

  52. Ishibe T, Takahashi S (2002) Respiratory Dysfunction in Patients with Chronic-Onset Cervical Myelopathy. Spine 27:2234–2239

    Article  PubMed  Google Scholar 

  53. Ishida K, Tani T, Ushida T, Zinchi V, Yamamoto H (2003) Recovery of Spinal Cord Conduction after Surgical Decompression for Cervical Spondylotic Myelopathy: Serial Somatosensory Evoked Potential Studies. Am. J Phys Med Rehabil 82:130–136

    Article  PubMed  Google Scholar 

  54. Johnston RA (1998) Review of the Spinal Complications of Rheumatoid Disease. Neurosurgery 8:206–215

    Google Scholar 

  55. Jones SJ (1977) Short Latency Potentials Recorded from the Neck and Scalp Following Median Nerve Stimulation in Man. Electroencephalograph. Clin Neurophysiol 43:853–863

    Article  CAS  Google Scholar 

  56. Kadanka Z, Mares M, Bednanik J, Smrcka V, Krbec M, Stejskal L, Chaloupka R, Surelova D, Novotny O, Urbanek I, Dusek L (2002) Approaches to Spondylotic Cervical Myelopathy: Conservative versus Surgical Results in a 3-Year Follow-Up Study. Spine 27:2205–2210

    Article  PubMed  Google Scholar 

  57. Kadoya S, Iizuka H, Nakamura T (2003) Long-Term Outcome for Surgically Treated Cervical Spondylotic Radiculopathy and Myelopathy. Neurol Med Chir (Tokyo) May 43(5):228–240

    Google Scholar 

  58. Kanchiku T, Taguchi T, Kaneko K, Fuchigami Y, Yonemura H, Kawai S (2001) A Correlation Between Magnetic Resonance Imaging and Electrophysiological Findings in Cervical Spondylotic Myelopathy. Spine 26:E294–E299

    Article  CAS  PubMed  Google Scholar 

  59. Kankaanpää U, Santavirta S (1985) Cervical Spine Involvement in Rheumatoid Arthritis. Ann Chir Gynaecol 74, 198:117–121

    Google Scholar 

  60. Kauppi M, Skaguchi M, Konttinen YT, Hämäläinen M, Hakala M (1996) Pathogenic Mechanism and Prevalence of the Stable Atlantoaxial Subluxation in Rheumatoid Arthritis. J Rheumtol 23:831–834

    CAS  Google Scholar 

  61. Kauppi M, Neva MH (1998) Sensitivity of Lateral View Cervical Spine Radiographs Taken in the Neutral Position in Atlantoaxial Subluxation in Rheumatic Diseases. Clin Rheumatol 17:511–514

    CAS  PubMed  Google Scholar 

  62. King JTjr, McGinnis KA, Roberts MS (2003) Quality of Life Assessment with the Medical Outcomes Study Short Form-36 among Patients with Cervical Spondylotic Myelopathy. Neurosurgery 52:113–120

    Article  PubMed  Google Scholar 

  63. Kohno K, Kumon Y, Oka Y, Matsui S, Ohue S, Sakaki S (1997) Evaluation of Prognostic Factors Following Extensive Laminoplasty for Cervical Spinal Stenotic Myelopathy. Surg Neurol 48:237–245

    Article  CAS  PubMed  Google Scholar 

  64. Kothe R, Wiesner L, Rüther W (2002) Die rheumatische Halswirbelsäule. Orthopäde 31:1114–1122

    Article  CAS  Google Scholar 

  65. Kühne D, Nahser HC, de Silva D, Feldges A, Heienbrok WH, Lalik J (1988) In: MNadjmi (ed) Pre- and Postoperative MRI Findings in Imaging of Brain Metabolism, Spine and Cord. Interventional Neurorad. Free Communications (1988) Spinal Cord Lesions Due to Cervical Myelopathy. Springer, Berlin, pp 223–232

  66. Kühne D (1991) Möglichkeiten moderner bildgebender Verfahren zur Diagnostik der zervikalen Myelopathie. Die Wirbelsäule in Forschung und Praxis 113:25–30

    Google Scholar 

  67. Kunze K, Arlt AC (1991) Klinik und Differentialdiagnose der zervikalen Myelopathie. Die Wirbelsäule in Forschung und Praxis 113:49–63

    Google Scholar 

  68. Latimer M, Haden N, Seeley HM, Laing RJ (2002) Measurement of Outcome in Patients with Cervical Spondylotic Myelopathy Treated Surgically. Br J Neurosurg 16(6):545–549

    CAS  PubMed  Google Scholar 

  69. Levin KH, Maggiano HJ, Wilbourn AJ (1996) Cervical Radiculopathies: Comparison of Surgical and EMG Localization of Single-Root Lesions. Neurology 46:1022–1025

    CAS  PubMed  Google Scholar 

  70. Lo YL, Chan LL, Lim W, Tan SB, Tan CT, Chen JLT, Fook-Chong S, Ratnagopal P (2004) Systematic Correlation of Transcranial Magnetic Stimulation and Magnetic Resonance Imaging in Cervical Spondylotic Myelopathy. Spine 29:1137–1145

    Article  CAS  PubMed  Google Scholar 

  71. Maertens de Noordhout A, Myressiotis S, Delvaux V, Born JD, Delwaide PJ (1998) Motor and Somatosensory Evoked Potentials in Cervical Spondylotic Myelopathy. Electroencephalograph. Clin Neurophysiol 108:24–31

    Google Scholar 

  72. Maestre-Moreno JF, Fernandez-Perez MD (2002) Natural Evolution of Radiculopathies and Myelopathies caused by Cervical Arthrosis. Rev. Neurol. 34(11):1087–1091

    CAS  PubMed  Google Scholar 

  73. Marks JS, Sharp J (1981) Rheumatoid Cervical Myelopathy. Quart J Med 199:307–319

    Google Scholar 

  74. Martel W (1961) The Occipito-Atlanto-Axial Joints in Rheumatoid Arthritis and Ankylosing Spondylitis. Am J Roentgenol 86:223–240

    CAS  Google Scholar 

  75. Martel W (1977) Pathogenesis of Cervical Discovertebral Destruction in Rheumatoid Arthritis. Arthritis and Rheumatism 20:1217–1225

    CAS  PubMed  Google Scholar 

  76. Mathews JA (1968) Atlanto-Axial Subluxation in Rheumatoid Arthritis. Ann Rheum Dis 28:260

    Google Scholar 

  77. Mathews JA (1974) Atlanto-axial Subluxation in Rheumatoid Arthritis—A 5 Year Follow Up Study. Ann Rheum Dis 33:526–531

    CAS  PubMed  Google Scholar 

  78. Matsuda Y, Miyasaki K, Tada K, Yasuda A, Nakayama T, Murakami H, Matsuo M (1991) Increased MR Signal Intensity Due to Cervical Myelopathy. J Neurosurg 74:887–892

    CAS  PubMed  Google Scholar 

  79. Matsuda Y, Shibata T, Oki S, Kawatani Y, Massima N, Oishi H (1999) Outcomes of Surgical Treatment for Cervical Myelopathy in Patients more than 75 Years of Age. Spine 24:529–534

    Article  CAS  PubMed  Google Scholar 

  80. Matsumoto M, Fujimura Y, Suzuki N, Nishi Y, Nakamura M, Yabe Y, Shiga H (1998) MRI and Cervical Intervertebral Discs in Asymptomatic Subjects. J Bone Joint Surg Br 80:19–24

    Article  CAS  PubMed  Google Scholar 

  81. Matsumoto M, Toyama Y, Ishikawa M, Chiba K, Suzuki N, Fujimura J (2000) Increased Signal Intensit of the Spinal Cord on Magnetic Resonance Images in Cervical Compressive Myelopathy: Does it Predict the Outcome of Conservative Treatment? Spine 25:677–682

    Article  CAS  PubMed  Google Scholar 

  82. Matsunaga S, Sakou T, Onishi T, Hayashi K, Taketomi E, Sunahara N, Komiya S (2003) Prognosis of Patients with Upper Cervical Lesions cuased by Rheumatoid Arthritis: Comparison of Occipitocervical Fusion between C1 Laminectomy and Nonsurgical Management. Spine 28:1581–1587

    Article  PubMed  Google Scholar 

  83. McCormick WE, Steinmetz MP, Benzel EC (2003) Cervical Spondylotic Myelopathy: Make the Difficult Diagnosis, then Refer for Surgery. Cleve. Clin J Med 70–10:899–904

    Google Scholar 

  84. Meikle JAK, Wilkinson M (1971) Rheumatoid Involvement of the Cervical Spine—Radiological Assessment. Ann Rheum Dis 30:154–161

    CAS  PubMed  Google Scholar 

  85. Mikulowski P, Wollheim FA, Rotmil P, Olsen I (1975) Sudden Death in Rheumatois Arthritis with Atlantoaxial Dislocation. Acta med scand 198:445–451

    CAS  PubMed  Google Scholar 

  86. Mizuno J, Nakagawa H, Inoue T, Hashizume Y (2003) Clinicopathological Study of “Snake-Eye Appearance” in Compressive Myelopathy of the Spinal Cord. J Neurosurg Sep 99 (Suppl 2):162–168

    Google Scholar 

  87. Mori T, Matsunaga S, Sunahara N, Sakou T (1998) 3 to 11 Year Follow Up of Occipitocervical Fusion for Rheumatoid Arthritis. Clin Orthop 351:169–179

    PubMed  Google Scholar 

  88. Morio Y, Teshima R, Nagashima H, Nawata K, Yamasaki D, Nanjo Y (2001) Correlation Between Operative Outcomes of Cervical Compression Myelopathy and MRI of the Spinal Cord. Spine 26:1238–1245

    Article  CAS  PubMed  Google Scholar 

  89. Mossmann SS, Jestico JV (1983) Central Cord Lesions in Cervical Spondylotic Myelopathy. J Neurol 230:227–230

    PubMed  Google Scholar 

  90. Mukai Y, Hosono N, Sakaura H, Ishii T, Fuchiya T, Fijiwara K, Fuji T, Yoshikawa H (2004) Laminoplasty for Cervical Myelopathy caused by Subaxial Lesions in Rheumatoid Arthritis. J Neurosurg 100 (Suppl 1):7–12

    Google Scholar 

  91. Neva MH, Kaarela K, Kauppi M (2000) Prevalence of Radiological Changes in the Cervical Spine—A Cross Sectional Study after 20 Years from Presentation of Rheumatoid Arthritis. J Rheumatol 27:90–93

    CAS  PubMed  Google Scholar 

  92. Nakamura K, Kurokawa T, Hoshino Y, Saita K, Takeshita K, Kawaguchi H (1998) Conservative Treatment for Cervical Spondylotic Cervical Myelopathy: Achievement and Sustainability of a Level of no Disability. J Spinal Disord 11:175–179

    CAS  PubMed  Google Scholar 

  93. Nakano KK, Schoene WE, Baker RA, Dawson DM (1978) The Cervical Myelopathy Associated with Rheumatoid Arthritis. Analysis of 32 Patients with Two Postmortem Cases. Ann Neurol 3:144–151

    CAS  PubMed  Google Scholar 

  94. Nove-Josserand A, Andre-Obadia N, Maugiere F (2002) Cervical Spondylotic Myelopathy: Motor and Somatosensory Evoked Potentials, Clinical and Radiological Correlation. Rev Neurol (Paris) 158:1191–1197

    CAS  Google Scholar 

  95. O’Brien MF, Casey AT, Crockard A, Pringle J, Stevens JM (2002) Histology of the Craniocervical Junction in Chronic Rheumatoid Arthritis: A Clinicopathologic Analysis of 33 Operative Cases. Spine 27:2245–2254

    Article  PubMed  Google Scholar 

  96. Oda T, Fujiwara K, Yonenobu K, Azuma B, Ochi T (1995) Natural Corse of Cervical Spine Lesions in Rheumatoid Arthritis. Spine 20:1128–1135

    CAS  PubMed  Google Scholar 

  97. Ogawa S (2000) Mortality of the Patients with Surgically Treated Cervical Spondylotic Myelopathy. Cent. Jpn. J Orthop Traumat 42:1313–1319

    Google Scholar 

  98. Ogino H, Tada K, Okada K (1983) Canal Diameter, Antero-Posterior Compression Ratio and Spondylotic Myelopathy of the Cervical Spine. Spine 8:1–15

    CAS  PubMed  Google Scholar 

  99. Okada Y, Ikata T, Yamada H, Sakamoto R, Katoh S (1993) Magnetic Resonance Imaging Study on the Results of Surgery for Cervical Compression Myelopathy. Spine 18:2024–2029

    CAS  PubMed  Google Scholar 

  100. Omura K, Hukuda S, Katsuura A, Saruhashi Y, Imanaka T, Imai S (2002) Evaluation of Posterior Long Fusion versus Conservative Treatment for the Progressive Rheumatoid Cervical Spine. Spine 27:1336–1345

    Article  PubMed  Google Scholar 

  101. Papyrus Edwin Smith (1700 v. Chr.) Fallnr 31, 33, 48

  102. Park WM, O’Neill M, McCall IW (1979) The Radiology of Rheumatoid Involvement of the Cervical Spine. Skeletal Radiol 4:1–7

    CAS  PubMed  Google Scholar 

  103. Pellicci PM, Ranawat CS, Tsairis P, Bryan WJ (1981) A Prospective Study of the Progression of Rheumatoid Arthritis of the Cervical Spine. J Bone Jt. Surgery 63:342–350

    CAS  Google Scholar 

  104. Peppelman WC, Kraus DR, Donaldson WFIII, Agarwal A (1993) Cervical Spine Surgery in Rheumatoid Arthritis: Improvement of Neurological Deficit afet Cervical Spine Fusion. Spine 18:2375–2379

    CAS  PubMed  Google Scholar 

  105. Plotz GM, Schutz U, Grob D (1998) Die okzipito-zervikale Fusion bei chronischer Polyarthritis. Z Rheumatol 57:147–158

    Article  CAS  PubMed  Google Scholar 

  106. Puttlitz CM, Goel VK, Clark CR, Traynelis VC, Scifert JL, Grosland NM (2000) Biomechanical Rational for the Pathology of Rheumatoid Arthritis in the Craniovertebral Junction. Spine 25:1607–1616

    Article  CAS  PubMed  Google Scholar 

  107. Rana NA (1989) Natural History of Atlanto-Axial Subluxation in Rheumatoid Arthritis. Spine 14:1054–1056

    CAS  PubMed  Google Scholar 

  108. Ranawat CS, O’Leary P, Pellicci P, Tsairis P, Marchisello P, Dorr L (1979) Cervical Spine Fusion in Rheumatoid Arthritis. J Bone Joint Surg Am 61:1003–1010

    CAS  PubMed  Google Scholar 

  109. Rao R (2003) Neck Pain, Cervical Radiculopathy, and Cervical Myelopathy: Pathophysiology, Natural History, and Clinical Evaluation. Instr Course Lect 52:479–488

    PubMed  Google Scholar 

  110. Rasker JJ, Cosh JA (1978) Radiological Study of Cervical Spine and Hand in Patients with Rheumatoid Arthritis of 15 Years Duration. An Assessment of the Effects of Corticosteroid Treatment. Ann Rheum Dis 37:529

    CAS  PubMed  Google Scholar 

  111. Rawlins BA, Girardi FP, Boachie-Adjei O (1998) Rheumatoid Arthritis of the Cervical Spine. Rheumatic Disease Clinics of North America 24:55–65

    CAS  PubMed  Google Scholar 

  112. Redlund-Johnell I, Pettersson H (1984) Radiographic Measurements of the Cranio-Vertebral Region. Acta Radiol 25:23–28

    CAS  Google Scholar 

  113. Redlund-Johnell I, Pettersson H (1985) Subaxial Antero-Posterior Dislocation of the Cervical Spine in Rheumatoid Arthritis. Scand. J Rheumatology 14:355–363

    CAS  Google Scholar 

  114. Restuccia D, Valeriani M, Lazzaro VD, Tonali P, Maugiere F (1994) Somatosensory Evoked Potentials after Multisegmental Upper Limb Stimulation in Diagnosis of Cervical Spondylotic Myelopathy. J Neurol Neurosurg Psychiatry 57:301–308

    CAS  PubMed  Google Scholar 

  115. Riew KD, Hilibrand AS, Palumbo MA, Sethi N, Bohlman HH (2001) Diagnosing Basilar Invagination in the Rheumatoid Patient. The Reliability of Radiographic Criteria. J Bone Joint Surg Am 83:194–200

    Google Scholar 

  116. Sampath B, Bendebba M, Davis JD, Duckter TB (2000) Outcome of Patients Treated for Cervical Myelopathy: A Prosepctive Multicenter Study with Independent Clinical Review. Spine 25:670–676

    Article  CAS  PubMed  Google Scholar 

  117. Santavirta S, Slatis P, Kankaanpaa U, Sandelin J, Laasonen E (1988) Treatment of the Cervical Spine in Rheumatoid Arthritis. J Bone Joint Surg Am 80:658–666

    Google Scholar 

  118. Schilling F, Schacherl M, Bopp A, Gamp A, Haas J-P (1963) Veränderungen der Halswirbelsäule bei der chronischen Polyarthritis und bei der Spondylitis ankylopoetica. Radiologe 3:483

    Google Scholar 

  119. Schilling F, Haas J-P, Schacerl M (1963) Die spontane atlanto-axiale Dislokation (Ventralluxation des Atlas) bei chronischer Polyarthritis und Spondylitis ankylopoetica. Fortschr Röntgenstr 99:518

    CAS  Google Scholar 

  120. Schilling F (1987) Die rheumatoide Zervikalarthritis. Akt Rheumatol 12:88–98

    Google Scholar 

  121. Schleich A, Albrecht HJ, Nusselt L, Rave O, Weller E, Westerburg KW (1985) Zur Risikobeurteilung occipito-cervicaler Dislokationen bei entzündlich-rheumatischen Erkrankungen. Z Rheumatol 44:120–132

    CAS  PubMed  Google Scholar 

  122. Sharp J, Purser OW, Lawrence JS (1958) Rheumatoid Arthritis of the Cervical Spine in the Adult. Ann Rheum Dis 17:303–313

    CAS  PubMed  Google Scholar 

  123. Sharp J, Purser OW (1961) Spontaneous Atlantoaxial Dislocation in Ankylosing Spondylitis an Rheumatoid Arthritis. Ann Rheum Dis 20:47

    Google Scholar 

  124. Simo M, Aranyi Z (2003) Role of Motor Evoked Potentials in the Diagnosis of Myelopathy associated with Cervical Spondylosis. Ideggyogy Sz 56:51–57

    PubMed  Google Scholar 

  125. Smith PH, Benn RT, Scharp J (1972) Natural History of Rheumatoid Cervical Luxations. Ann Rheum Dis 31:431

    CAS  PubMed  Google Scholar 

  126. Stevens JC, Cartlidge NEF, Saunders M, Appleby A, Hall M, Shaw DA (1971) Atlanto-axial Subluxation and Cervical Myelopathy in Rheumatoid Arthritis. Quart J Med 40:391

    CAS  PubMed  Google Scholar 

  127. Suda K, Abumi K, Ito M, Shono Y, Kaneda K, Fujiya M (2003) Local Kyphosis Reduces Surgical Outcomes of Expansive Open-Door Laminoplasty for Cervical Spondylotic Myelopathy. Spine 28:1258–1262

    Article  PubMed  Google Scholar 

  128. Sunuhara N, Matsunaga S, Mori T, Ijiri K, Sakou T ((1997) Clinical Corse of Conservatively Managed Rheumatoid Arthritis Patients with Myelopathy. Spine 22:2603–2608

    Article  CAS  PubMed  Google Scholar 

  129. Suri A, Chabbra RP, Mehta VS, Gaikwad S, Pandey RM (2003) Effect of Intramedullary Signal Changes on the Surgical Outcome in Patients with Cervical Spondylotic Myelopathy. Spine J (2003) Jan–Feb 3(1):33–45

    Article  PubMed  Google Scholar 

  130. Takahashi M, Yamashita Y, Sakamoto Y, Kojima R (1989) Chronic Cervical Cord Compression: Clinical Significance of Increased Signal Intensity on MR Images. Radiology 173:219–224

    CAS  PubMed  Google Scholar 

  131. Tavy DLJ, Wagner LG, Keunen RWM, Wattendorf AR, Hekster RE, Franssen H (1994) Transcranial Magnetic Stimulation in Patients with Cervical Spondylotic Myelopathy: Clinical and Radiological Correlations. Muscle Nerve 17:235–241

    CAS  PubMed  Google Scholar 

  132. Tavy DLJ, Franssen H, Keunen RWM, Wattendorf AR, Hekster RE, van Huffelen AC (1999) Motor and Somatosensory Evoked Potentials in Asymptomatic Spondylotic Cord Compression. Muscle Nerve 22:628–634

    Article  CAS  PubMed  Google Scholar 

  133. Tegenthoff M (1991) Diagnostische Relevanz neurophysiologischer Befunde bei zervikalen Myelopathien. Die Wirbelsäule in Forschung und Praxis 113:35–41

    Google Scholar 

  134. Teresi LM, Lufkin RB, Reicher MA, Moffit B, Vinuela FV, Wilson GM, Bentson JR, Hanafee WN (1987) Asymptomatic Degenerative Disc Disease and Spondylosis of the Cervical Spine. Radiology 164:83–88

    CAS  PubMed  Google Scholar 

  135. Thabe H (1981) Atlantodentale Dislokation bei chronischer Polyarthritis. Korrelation klinischer, röntgenologischer, neurologischer und elektromyographischer Befunde. Z Rheumatol 40:6–11

    CAS  PubMed  Google Scholar 

  136. Thompson PD, Dick JPR, Asselman P, Griffin GB, Day BL, Rothwell JC, Sheeley MP, Marsden CD (1987) Examination of Motor Function in Lesions of the Spinal Cord by Stimulation of the Motor Cortex. Ann Neurol 21:389–396

    CAS  PubMed  Google Scholar 

  137. Tsiptsios I, Fotiou F, Sitzoglou K, Fountoulakis KN (2001) Neurophysiological Investigation of Cervical Spondylosis. Electromyogr. Clin Neurophysiol 41(5):305–313

    CAS  Google Scholar 

  138. Veilleux M, Daube J (1987) The Value of Ulnar Somatosensory Evoked Potentials (SEPs) in Cervical Myelopathy. Electroencephalogr. Clin Neurophysiol 68:415–423

    Article  CAS  Google Scholar 

  139. Vu Nguyen H, Ludwig SC, Silber J, Gelb DE, Anderson PA, Frank I, Vaccaro AR (2004) Rheumatoid Arthritis of the Cervical Spine. Spine J May–Jun 4/3:329–334

    Article  PubMed  Google Scholar 

  140. Wada E, Yonenobu K, Suzuki S, Kanazawa A, Ochi T (1999) Can Intramedullary Signal Change on Magnetic Resonance Imaging Predict Surgical Outcome in Cervical Spondylotic Myelopathy? Spine 24:455–462

    Article  CAS  PubMed  Google Scholar 

  141. Ward MM (2004) Decreases in Rates of Hospitalisations for manifestations of Severe Rheumatoid Arthritis. Arthritis Rheum 50:1122–1131

    Article  PubMed  Google Scholar 

  142. Ware JEjr, Sherbourne CD (1992) A MOS 36-Item Short-Form Health Survey (SF-36): Part I—Conceptual Framework and Item Selection. Med Care 30:473–483

    PubMed  Google Scholar 

  143. Ware JE Jr, Kosinski M, Keller SD (1994) SF-36 Physical and Mental Health Summary Scales: A User’s Manual. Boston, Health Assessment Lab

  144. Ware JE Jr, Snow KK, Kosinski M (2000) SF-36 Health Survey: Manual and Interpretation Guide. Lincoln, Quality Metric Inc

  145. Weissmann BN, Aliabadi P, Weinfeld MS, Thomas WH, Sosman JL (1982) Prognostic Features of Atlantoaxial Subluxation in Rheumatoid Arthritis. Radiology 144:745

    PubMed  Google Scholar 

  146. Whaley K, Carson DW (1968) Fatal Subaxial Dislocation of Cervical Spine in Rheumatoid Arthritis. Brit med J 2:31

    Google Scholar 

  147. Wilkins RH (1964) Neurosurgical Classic-XVII Edwin Smith Surgical Papyrus. J Neurosurgery, pp 240–244

  148. Winfield J, Cooke D, Brook AS, Corbett M (1981) A Prospective Study of the Radiological Changes in the Cervical Spine in Early Rheumatoid Disease. Ann Rheum Dis 40:109–114

    CAS  PubMed  Google Scholar 

  149. Yamada M, Furukawa Y, Hirohata M (2003) Amyotrophic Lateral Sclerosis: Frequent Complications by Cervical Spondylosis. J Orthop Sci 8:878–881

    Article  PubMed  Google Scholar 

  150. Yamazaki T, Yanaka K, Sato H, Uemura K, Tsukada A, Nose T (2003) Cervical Spondylotic Myelopathy: Surgical Results and Factors Affecting Outcome with special Reference to Age Differences. Neurosurgery 52:122–126

    Article  PubMed  Google Scholar 

  151. Yiannikas C, Shahani BT, Young RR (1968) Short-Latency Somatosensory Evoked Potentials from Radial, Median, Ulnar, and Peroneal Nerve Stimulation in the Assessment of Cervical Spondylosis. Arch Neurol 43:12164–1271

    Google Scholar 

  152. Yonenobu K (2000) Cervical Radiculopathy and Myelopathy: When and What can Surgery Contribute to Treatment? Eur. Spine J 9:1–7

    Article  CAS  PubMed  Google Scholar 

  153. Yu YL, Jones SI (1985) Somatosensory Evoked Potentials in Cervical Spondylosis. Brain 108:273–300

    PubMed  Google Scholar 

  154. Zeidman SM, Drucker TB (1994) Rheumatoid Arthritis. Neuroanatomy, Compression, and Grading of Deficits. Spine 19:2259–2266

    CAS  PubMed  Google Scholar 

  155. Zhang HQ, Long WR, Li KH (2002) Efficacy of Operation in the Treatment of Cervical Spondylotic Myelopathy in Different Disease Periods. Hunan Yi Ke Da Xue Xue Bao 27:64–66

    CAS  PubMed  Google Scholar 

  156. Zoma A, Sturrock RD, Fisher WD, Freeman PA, Hamblen DL (1987) Surgical Stabilisation of the Rheumatoid Cervical Spine: A Review of Indications and Results. J Bone Joint Surg Br 69:8–12

    CAS  PubMed  Google Scholar 

  157. Zygmunt S, Saveland H, Brattstrom H, Ljungren B, Larsson EM, Wollheim F (1988) Reduction of Rheumatoid Periodontoid Pannus Following Posterior Occipitocervical Fusion Visualited by Magnetic Resonance Imaging. Br J Neurosurg 2:315–320

    CAS  PubMed  Google Scholar 

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Arlt, A.C., Steinmetz, J. Die Zervikale Myelopathie als Komplikation der Rheumatoiden Arthritis. Z Rheumatol 63, 281–295 (2004). https://doi.org/10.1007/s00393-004-0648-6

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