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Zeitschrift für Gerontologie und Geriatrie
Erschienen in: Zeitschrift für Gerontologie und Geriatrie 4/2014

01.06.2014 | Beiträge zum Themenschwerpunkt

Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients

verfasst von: M. Gogol, H. Hartmann, S. Wustmann, A. Simm

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 4/2014

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Abstract

Introduction

Growing evidence shows a high correlation between extensive use of central nervous system-acting drugs (CNSADs) in elderly patients and adverse drug reactions (ADRs) such as falls, fractures, and mortality.

Research question

Are results of cognitive testing with the Mini Mental Status Examination (MMSE) influenced by use of CNSADs?

Setting

Geriatric inpatient service for acute, subacute, and rehabilitation care.

Methods

Secondary combined analysis of two prospective, single-center study cohorts (PROPSYC, 2011 and AGE OUT, 2012) with identical procedure for the MMSE at a tertiary hospital.

Results

Overall, 395 patients were included, 144 male (M) and 251 female (F). Mean age was 80.0 ± 8.4 years (M 76.7 ± 9.1, F 81.9 ± 7.3, p = 0.0000). Mean MMSE points were 22.9 ± 4.8 (M 23.2 ± 4.6, F 22.6 ± 5.0, p = 0.211). In total, 258 patients (65.3 %) used drugs with potential adverse cognitive properties. Analgesics with central activity were given to 117 of 395 patients (29.6 %). Low-potency opioids (tramadol hydrochloride, tilidine) were identified in 60 patients and high-potency opioids in 57 patients. Antidepressants were used in 66 patients, benzodiazepines in 26, and hypnotics in 11, while 38 patients received other CNSADs. We only found significant correlations with the results of cognitive testing for sedatives (diazepam and oxazepam, Pearson’s r − 0.79, p = 0.05), but not for lorazepam.

Conclusion

Our analysis shows an influence of sedatives (diazepam and oxazepam, but not lorazepam) on cognitive testing with the MMSE in users of CNSADs.
Vorheriger Artikel Medikamentöse Therapie im Alter
Nächster Artikel Design of pharmaceutical products to meet future patient needs requires modification of current development paradigms and business models
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Metadaten
Titel
Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients
verfasst von
M. Gogol
H. Hartmann
S. Wustmann
A. Simm
Publikationsdatum
01.06.2014
Verlag
Steinkopff-Verlag
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 4/2014
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-014-0654-5

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