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Erschienen in: Zeitschrift für Gerontologie und Geriatrie 6/2011

01.12.2011 | Beiträge zum Themenschwerpunkt

Treatment of osteoporosis in postmenopausal hip fracture patients after geriatric rehabilitation

Changes over the last decade

verfasst von: Mag. Dr. M. Gosch, MAS, T. Roth, C. Kammerlander, B. Joosten-Gstrein, U. Benvenuti-Falger, M. Blauth, M. Lechleitner

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 6/2011

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Abstract

Background

Osteoporotic hip fractures are a major cause of morbidity and mortality in postmenopausal women, and their impacts on society are substantial. Although adequate osteoporotic treatment reduces the risk of subsequent fractures and also mortality, only a minor proportion of the patients receives sufficient therapy.

Objectives

The goal of the present study was to evaluate osteoporosis treatment in two different cohorts and to describe the changes after the implementation of a Geriatric Facture Center (GFC) in cooperation with a level 1 trauma center.

Study design

A retrospective, single-center cross sectional study design was used.

Methods

A total of 455 patients (70 years and older) were included at our department of geriatric medicine. The patients were split into two groups. The usual care (UC) group consisted of 327 patients admitted to our department from 2001–2004. The GFC group included 128 patients admitted from 2009–2010. In addition to recording osteoporosis therapy, we collected demographic data, comorbidities, and different functional parameters of the patients. The data were collected retrospectively using medical records. SPSS 18.0 was used for statistical analysis.

Results

Of the patients, 43% in the GFC group received a specific antiresorptive or anabolic treatment (SAAT). Basic treatment with calcium and vitamin D3 was prescribed in 88% of the patients. The diagnosis “osteoporosis” was found in 73.4% of the discharge letters. In the UC group, the percentage of patients with a SAAT was 14.7%, calcium and vitamin D3 was prescribed in 30%, and the diagnosis was documented in 24.5%. All these differences are statistically significant (p < 0.0001). In the GFC group, better functional status and cognition were significantly associated with a higher rate of a prescribed SAAT, whereas age and comorbidities showed a negative association.

Conclusion

Our results show that the management of osteoporosis in postmenopausal hip fracture patients has significantly improved over the last decade. From our point of view, the main impact on this development is due to the implementation of a GFC with corresponding guidelines and treatment steps. In addition to structural changes, the improved evidence for osteoporosis treatment, especially of geriatric patients, has a positive influence on osteoporosis therapy.
Literatur
2.
3.
Zurück zum Zitat Magaziner J, Simonsick EM, Kashner TM et al (1990) Predictors of functional recovery one year following hospital discharge for hip frature: a prospective study. J Gerontol 45:M101–M107PubMed Magaziner J, Simonsick EM, Kashner TM et al (1990) Predictors of functional recovery one year following hospital discharge for hip frature: a prospective study. J Gerontol 45:M101–M107PubMed
4.
Zurück zum Zitat Center JR, Bliuc D, Nguyen TV et al (2007) Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 297:387–394PubMedCrossRef Center JR, Bliuc D, Nguyen TV et al (2007) Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 297:387–394PubMedCrossRef
5.
Zurück zum Zitat Bliuc D, Nguyen ND, Milch VE et al (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and woman. JAMA 301(5):513–521PubMedCrossRef Bliuc D, Nguyen ND, Milch VE et al (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and woman. JAMA 301(5):513–521PubMedCrossRef
6.
Zurück zum Zitat Clinician’s Guide to Prevention and Treatment of Osteoporosis (2009) National Osteoporosis Foundation [on-line]. Available at http://www.nof.org/professionals/NOF_Clinicians_Guide.pdf. Accessed 01 November 2011 Clinician’s Guide to Prevention and Treatment of Osteoporosis (2009) National Osteoporosis Foundation [on-line]. Available at http://​www.​nof.​org/​professionals/​NOF_​Clinicians_​Guide.​pdf.​ Accessed 01 November 2011
7.
Zurück zum Zitat NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy (2001) Osteoporosis prevention, diagnosis and therapy. JAMA 285:785–795CrossRef NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy (2001) Osteoporosis prevention, diagnosis and therapy. JAMA 285:785–795CrossRef
8.
Zurück zum Zitat Lyles KW, Colon-Emeric CS, Magaziner JS et al (2007) Zoledronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 357:1799–1809PubMedCrossRef Lyles KW, Colon-Emeric CS, Magaziner JS et al (2007) Zoledronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 357:1799–1809PubMedCrossRef
9.
Zurück zum Zitat MacLean C, Newberry S, Maglione M et al (2008) Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med 148:197–213PubMed MacLean C, Newberry S, Maglione M et al (2008) Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med 148:197–213PubMed
10.
Zurück zum Zitat Morin S, Rahme E, Behlouli H et al (2007) Effectiveness of antiresorptive agents in the prevention of recurrent hip fractures. Osteoporos Int 18:1625–1632PubMedCrossRef Morin S, Rahme E, Behlouli H et al (2007) Effectiveness of antiresorptive agents in the prevention of recurrent hip fractures. Osteoporos Int 18:1625–1632PubMedCrossRef
11.
Zurück zum Zitat Kammerlander C, Gosch M, Kammerlander-Knauer U et al (2011) Long-term functional outcome in geriatric patients hip fracture patients. Arch Orthop Trauma Surg. doi 10.1007/s00402-011-1313-6 Kammerlander C, Gosch M, Kammerlander-Knauer U et al (2011) Long-term functional outcome in geriatric patients hip fracture patients. Arch Orthop Trauma Surg. doi 10.1007/s00402-011-1313-6
12.
Zurück zum Zitat Jennings LA, Auerbach AD, Maselli J et al (2010) Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture. J Am Geriatr Soc 58:650–657PubMedCrossRef Jennings LA, Auerbach AD, Maselli J et al (2010) Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture. J Am Geriatr Soc 58:650–657PubMedCrossRef
13.
Zurück zum Zitat Leyles KW, Colon-Emerie CS, Magaziner JS et al (2007) Zoledronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 357:1799–1809CrossRef Leyles KW, Colon-Emerie CS, Magaziner JS et al (2007) Zoledronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 357:1799–1809CrossRef
14.
Zurück zum Zitat Black DM, Delmas PD, Eastell R et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809–1833PubMedCrossRef Black DM, Delmas PD, Eastell R et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809–1833PubMedCrossRef
15.
Zurück zum Zitat Bolland MJ, Grey AB, Gamble GD et al (2010) Effect of osteoporosis treatment on mortality: a meta analysis. J Clin Endocrinol Metab 95:1174–1181PubMedCrossRef Bolland MJ, Grey AB, Gamble GD et al (2010) Effect of osteoporosis treatment on mortality: a meta analysis. J Clin Endocrinol Metab 95:1174–1181PubMedCrossRef
16.
Zurück zum Zitat Bogoch ER, Elliot-Gibson V, Beaton DE et al (2006) Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopedic environment. J Bone Joint Surg Am 88(1):25–34PubMedCrossRef Bogoch ER, Elliot-Gibson V, Beaton DE et al (2006) Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopedic environment. J Bone Joint Surg Am 88(1):25–34PubMedCrossRef
17.
Zurück zum Zitat Friedman SM, Mendelson DA, Bingham KW et al (2009) Impact of a comanaged geriatric fracture center on short-term hip fracture outcomes. Arch Intern Med 169(18):1712–1717PubMedCrossRef Friedman SM, Mendelson DA, Bingham KW et al (2009) Impact of a comanaged geriatric fracture center on short-term hip fracture outcomes. Arch Intern Med 169(18):1712–1717PubMedCrossRef
18.
Zurück zum Zitat Shyu YI, Liang J, Wu CC et al (2010) Two-year effects of interdisciplinary intervention for hip fracture in older Taiwanese. J Am Geriatr Soc 58:1081–1089PubMedCrossRef Shyu YI, Liang J, Wu CC et al (2010) Two-year effects of interdisciplinary intervention for hip fracture in older Taiwanese. J Am Geriatr Soc 58:1081–1089PubMedCrossRef
19.
Zurück zum Zitat Henry MJ, Pasco JA, Nicholson GC et al (2000) Prevalence of osteoporosis in Australian women: Geelong osteoporosis study. J Clin Densitom 3:261–268PubMedCrossRef Henry MJ, Pasco JA, Nicholson GC et al (2000) Prevalence of osteoporosis in Australian women: Geelong osteoporosis study. J Clin Densitom 3:261–268PubMedCrossRef
20.
Zurück zum Zitat Chiang A, Jones J, Humphreys J et al (2006) Osteoporosis, diagnosis and treatment in a general practice population. Aust Fam Physician 35(3):166–168PubMed Chiang A, Jones J, Humphreys J et al (2006) Osteoporosis, diagnosis and treatment in a general practice population. Aust Fam Physician 35(3):166–168PubMed
21.
Zurück zum Zitat Häussler B, Gothe H, Göl D et al (2007) Epidemiology, treatment and costs of osteoporosis in Germany – the BoneEVA Study. Osteoporos Int 18(1):77–84PubMedCrossRef Häussler B, Gothe H, Göl D et al (2007) Epidemiology, treatment and costs of osteoporosis in Germany – the BoneEVA Study. Osteoporos Int 18(1):77–84PubMedCrossRef
22.
Zurück zum Zitat McLellan AR, Wolowacz SE, Zimovetz EA et al (2011) Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 22:2083–2098PubMedCrossRef McLellan AR, Wolowacz SE, Zimovetz EA et al (2011) Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 22:2083–2098PubMedCrossRef
23.
Zurück zum Zitat Handoll HH, Cammeron ID, Mak JC et al (2009) Multidisciplinary rehabilitation for older patients with hip fractures. Cochrane Database Syst Rev 7(4):CD007125 Handoll HH, Cammeron ID, Mak JC et al (2009) Multidisciplinary rehabilitation for older patients with hip fractures. Cochrane Database Syst Rev 7(4):CD007125
24.
Zurück zum Zitat Inderjeeth CA, Foo ACH, Lai MMY et al (2009) Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: review of the literature. Bone 44:744–751PubMedCrossRef Inderjeeth CA, Foo ACH, Lai MMY et al (2009) Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: review of the literature. Bone 44:744–751PubMedCrossRef
25.
Zurück zum Zitat Boonen ST, Black DM, Clon-Emeric CS et al (2010) Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged over 75 and older. J Am Geriatr Soc 58:292–299PubMedCrossRef Boonen ST, Black DM, Clon-Emeric CS et al (2010) Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged over 75 and older. J Am Geriatr Soc 58:292–299PubMedCrossRef
26.
Zurück zum Zitat Boonen ST, Black DM, Clon-Emeric CS et al (2006) Safety and efficacy of teriparatide in elderly women with established osteoporosis: bone anabolic therapy from a geriatric perspective. J Am Geriatr Soc 54:782–789PubMedCrossRef Boonen ST, Black DM, Clon-Emeric CS et al (2006) Safety and efficacy of teriparatide in elderly women with established osteoporosis: bone anabolic therapy from a geriatric perspective. J Am Geriatr Soc 54:782–789PubMedCrossRef
27.
Zurück zum Zitat Meunier PJ, Roux C, Seeman E et al (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. SOTI study. N Engl J Med 350(5):459–468PubMedCrossRef Meunier PJ, Roux C, Seeman E et al (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. SOTI study. N Engl J Med 350(5):459–468PubMedCrossRef
28.
Zurück zum Zitat Cummings SR, San Martin J, McClung MR et al (2009) Denosumab for prevention of fractures in postmenopaual women with osteoporosis. N Engl J Med 361(8):756–765PubMedCrossRef Cummings SR, San Martin J, McClung MR et al (2009) Denosumab for prevention of fractures in postmenopaual women with osteoporosis. N Engl J Med 361(8):756–765PubMedCrossRef
29.
Zurück zum Zitat Gates BJ, Sonnett TE, Duvall CA et al (2009) Review of osteoporosis pharmacotherapy for geriatric patients. Am J Geriatr Pharmacother 7:293–323PubMedCrossRef Gates BJ, Sonnett TE, Duvall CA et al (2009) Review of osteoporosis pharmacotherapy for geriatric patients. Am J Geriatr Pharmacother 7:293–323PubMedCrossRef
30.
Zurück zum Zitat Schousboe JT, Ensrud KE, Nyman JA et al (2005) Universal bone densitometry screening combined with alendronate therapy for those diagnosed with osteoporosis is highly cost-effective for eldery women. J Am Geriatr Soc 53(10):1697–1704PubMedCrossRef Schousboe JT, Ensrud KE, Nyman JA et al (2005) Universal bone densitometry screening combined with alendronate therapy for those diagnosed with osteoporosis is highly cost-effective for eldery women. J Am Geriatr Soc 53(10):1697–1704PubMedCrossRef
Metadaten
Titel
Treatment of osteoporosis in postmenopausal hip fracture patients after geriatric rehabilitation
Changes over the last decade
verfasst von
Mag. Dr. M. Gosch, MAS
T. Roth
C. Kammerlander
B. Joosten-Gstrein
U. Benvenuti-Falger
M. Blauth
M. Lechleitner
Publikationsdatum
01.12.2011
Verlag
Springer-Verlag
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 6/2011
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-011-0254-6

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