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A comparative study of Sr-incorporated mesoporous bioactive glass scaffolds for regeneration of osteopenic bone defects

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Abstract

Summary

Recently, the use of the pharmacological agent strontium ranelate has come to prominence for the treatment of osteoporosis. While much investigation is focused on preventing disease progression, here we fabricate strontium-containing scaffolds and show that they enhance bone defect healing in the femurs of rats induced by ovariectomy.

Introduction

Recently, the use of the pharmacological agent strontium ranelate has come to prominence for the treatment of osteoporosis due to its ability to prevent bone loss in osteoporotic patients. Although much emphasis has been placed on using pharmacological agents for the prevention of disease, much less attention has been placed on the construction of biomaterials following osteoporotic-related fracture. The aim of the present study was to incorporate bioactive strontium (Sr) trace element into mesoporous bioactive glass (MBG) scaffolds and to investigate their in vivo efficacy for bone defect healing in the femurs of rats induced by ovariectomy.

Methods

In total, 30 animals were divided into five groups as follows: (1) empty defect (control), (2) empty defects with estrogen replacement therapy, (3) defects filled with MBG scaffolds alone, (4) defects filled with MBG + estrogen replacement therapy, and (5) defects filled with strontium-incorporated mesopore-bioglass (Sr-MBG) scaffolds.

Results

The two groups demonstrating the highest levels of new bone formation were the defects treated with MBG + estrogen replacement therapy and the defects receiving Sr-MBG scaffolds as assessed by μ-CT and histological analysis. Furthermore, Sr scaffolds had a reduced number of tartrate-resistant acid phosphatase-positive cells when compared to other modalities.

Conclusion

The results from the present study demonstrate that the local release of Sr from bone scaffolds may improve fracture repair. Future large animal models are necessary to investigate the future relationship of Sr incorporation into biomaterials.

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Acknowledgements

This project was supported by the Program for New Century Excellent Talents in University (NCET-11-0414), Excellent Youth Foundation of Hubei and the funds of the National Natural Science Foundation of China (81271108).

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People’s Republic of China

    L. Wei, J. Ke, R. J. Miron, S. Lin & Y. Zhang

  2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, People’s Republic of China

    J. Chang & C. Wu

  3. Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, Queensland, 4059, Australia

    I. Prasadam & Y. Xiao

  4. Department of Oral Implantology, School of Stomatology, Wuhan University, Wuhan, 430079, China

    Y. Zhang

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  1. L. Wei
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  2. J. Ke
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  3. I. Prasadam
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  4. R. J. Miron
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  5. S. Lin
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  6. Y. Xiao
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  7. J. Chang
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  8. C. Wu
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  9. Y. Zhang
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Corresponding authors

Correspondence to C. Wu or Y. Zhang.

Additional information

Lingfei Wei and Jin Ke contributed equally to this work.

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Wei, L., Ke, J., Prasadam, I. et al. A comparative study of Sr-incorporated mesoporous bioactive glass scaffolds for regeneration of osteopenic bone defects. Osteoporos Int 25, 2089–2096 (2014). https://doi.org/10.1007/s00198-014-2735-0

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  • DOI: https://doi.org/10.1007/s00198-014-2735-0

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