Abstract
Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (<0.1 % of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.
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Hanley, N.A., Bourke, J.P. & Gascoigne, A.D. Survival in a case of life-threatening flecainide overdose. Intensive Care Med 24, 740–742 (1998). https://doi.org/10.1007/s001340050655
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DOI: https://doi.org/10.1007/s001340050655