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Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients

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Abstract

Purpose

The goal of this study was to analyse a possible association of admission blood glucose with hospital mortality of polytraumatised patients and to develop an outcome prediction model for this patient group.

Methods

The outcome of adult polytraumatised patients admitted to the University Hospital of Berne, Switzerland, between 2002 and 2004 with an ISS ≥ 17, and more than one severely injured organ system was retrospectively analysed.

Results

The inclusion criteria were met by 555 patients, of which 108 (19.5%) died. Hyperglycaemia proved to be an independent predictor for hospital mortality (P < 0.0001), following multiple regression analysis. After inclusion of admission blood glucose, the calculated mortality prediction model performed better than currently described models (P < 0.0001, AUC 0.924).

Conclusion

In this retrospective, single-centre study in polytraumatised patients, admission blood glucose proved to be an independent predictor of hospital mortality following regression analysis controlling for age, gender, injury severity and other laboratory parameters. A reliable admission blood glucose-based mortality prediction model for polytraumatised patients could be established. This observation may be helpful in improving the precision of future outcome prediction models for polytraumatised patients. These observations warrant further prospective evaluation.

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Acknowledgments

The authors thank Prof. Juerg Huesler and Mrs. Eliane Gut (Institute for Mathematical Statistics and Insurance Calculations of the University of Berne, Switzerland), and Dr. Franziska Schöni-Affolter (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) for their support in statistical data analysis.

Conflict of interest statement

This study was solely financially supported by departmental resources. No author has a conflict of interest that relates to the content discussed in this article.

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Authors and Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria

    Janett Kreutziger & Volker Wenzel

  2. Department of Anaesthesiology, The Cleveland Clinic, Cleveland, OH, USA

    Andrea Kurz

  3. Department of Plastic, Reconstructive and Hand Surgery, Inselspital, University Hospital, Berne, Switzerland

    Mihai Adrian Constantinescu

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  1. Janett Kreutziger
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  2. Volker Wenzel
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  3. Andrea Kurz
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  4. Mihai Adrian Constantinescu
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Correspondence to Janett Kreutziger.

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Kreutziger, J., Wenzel, V., Kurz, A. et al. Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients. Intensive Care Med 35, 1234–1239 (2009). https://doi.org/10.1007/s00134-009-1446-z

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  • DOI: https://doi.org/10.1007/s00134-009-1446-z

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