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An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest

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Abstract

Objective

To identify predictors of brain death after successful resuscitation of out-of-hospital cardiac arrest (OHCA), with the goal of improving the detection of brain death, and to evaluate outcomes of solid organs harvested from these patients.

Design and setting

Prospective observational cohort study in a medical and surgical unit of a nonuniversity hospital.

Patients

Patients with successfully resuscitated OHCA were prospectively included in a database over a 7-year period. We looked for early predictors of brain death and compared outcomes of organ transplants from these patients to those from patients with brain death due to head injury or stroke.

Results

Over the 7-year period 246 patients were included. No early predictors of brain death were found. Of the 40 patients (16%) who met criteria for brain death, after a median ICU stay of 2.5 days (IQR 2.0–4.2), 19 donated 52 solid organs (29 kidneys, 14 livers, 7 hearts, and 2 lungs). Outcomes of kidneys and livers did not differ between donors with and without resuscitated cardiac arrest.

Conclusions

Brain death may occur in about one-sixth of patients after successfully resuscitated OHCA, creating opportunities for organ donation.

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Acknowledgements

We are indebted to A. Wolfe MD for helping with the manuscript.

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Correspondence to Christophe Adrie.

Additional information

C. A. received a grant from the publicly funded organization Agence de Biomédecine which manages organ donor data in France.

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Adrie, C., Haouache, H., Saleh, M. et al. An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest. Intensive Care Med 34, 132–137 (2008). https://doi.org/10.1007/s00134-007-0885-7

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  • DOI: https://doi.org/10.1007/s00134-007-0885-7

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