Skip to main content
SpringerLink
Log in

Behandlung der Depression bei koronarer Herzerkrankung

Treatment of depression in coronary heart disease

  • CME Zertifizierte Fortbildung
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

Zusammenfassung

Depression und koronare Herzerkrankung (KHK) sind führende Ursachen der globalen Krankheitslast und weisen eine hohe Komorbidität auf. Zudem stellt die Depression einen unabhängigen Risikofaktor für einen ungünstigeren Verlauf der KHK dar. Umgekehrt kann eine erfolgreiche Depressionsbehandlung zur Reduktion des kardialen Risikos führen. Aktuell stehen unterschiedliche Therapieoptionen zur Behandlung der Depression bei Patienten mit komorbider KHK zur Verfügung, die stufenweise oder kombiniert Anwendung finden. Eine besondere Bedeutung kommt dabei dem Selbstmanagement, der Psychotherapie, der Pharmakotherapie und neuen Versorgungsmodellen zu. Dieser Artikel bietet eine Übersicht zur Epidemiologie und Pathophysiologie der Depression bei Patienten mit KHK sowie zur Effektivität und Sicherheit verschiedener Therapieoptionen.

Summary

Depression and coronary heart disease (CHD) are leading causes of disability and show a high comorbidity. Furthermore, depression is an independent risk factor for an unfavorable course and increased mortality in patients with CHD. In contrast, successful treatment of depression can reduce the risk of cardiac events. Currently, there are several treatment options for the management of depression in CHD, including self-management strategies, psychotherapy, pharmacotherapy and collaborative care models. This article provides an overview of the epidemiology of depression in CHD, the mechanisms of association and the current state of evidence with respect to the different treatment options.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Vos T, Flaxman AD, Naghavi M et al (2012) Years lived with disability (ylds) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 380:2163–2196

    Article  PubMed  Google Scholar 

  2. Kuehl LK, Penninx BW, Otte C (2012) Depression: risk factor for cardiovascular disease. Nervenarzt 83:1379–1384

    Article  CAS  PubMed  Google Scholar 

  3. Whooley MA, Wong JM (2013) Depression and cardiovascular disorders. Annu Rev Clin Psychol 9:327–354

    Article  PubMed  Google Scholar 

  4. Ruo B, Rumsfeld JS, Hlatky MA et al (2003) Depressive symptoms and health-related quality of life: the heart and soul study. JAMA 290:215–221

    Article  PubMed Central  PubMed  Google Scholar 

  5. Lichtman JH, Froelicher ES, Blumenthal JA et al (2014) Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation 129:1350–1369

    Article  PubMed  Google Scholar 

  6. Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 27:2763–2774

    Article  PubMed  Google Scholar 

  7. Melle JP van, Jonge P de, Spijkerman TA et al (2004) Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med 66:814–822

    Article  PubMed  Google Scholar 

  8. Meijer A, Conradi HJ, Bos EH et al (2013) Adjusted prognostic association of depression following myocardial infarction with mortality and cardiovascular events: individual patient data meta-analysis. Br J Psychiatry 203:90–102

    Article  CAS  PubMed  Google Scholar 

  9. Bush DE, Ziegelstein RC, Tayback M et al (2001) Even minimal symptoms of depression increase mortality risk after acute myocardial infarction. Am J Cardiol 88:337–341

    Article  CAS  PubMed  Google Scholar 

  10. Stewart JC, Perkins AJ, Callahan CM (2014) Effect of collaborative care for depression on risk of cardiovascular events: data from the impact randomized controlled trial. Psychosom Med 76:29–37

    Article  PubMed Central  PubMed  Google Scholar 

  11. Lederbogen F, Strohle A (2012) Stress, mental disorders and coronary heart disease. Nervenarzt 83:1448–1457

    Article  CAS  PubMed  Google Scholar 

  12. Kemp AH, Quintana DS, Gray MA et al (2010) Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry 67:1067–1074

    Article  CAS  PubMed  Google Scholar 

  13. Otte C, Neylan TC, Pipkin SS et al (2005) Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the heart and soul study. Am J Psychiatry 162:2139–2145

    Article  PubMed Central  PubMed  Google Scholar 

  14. Penninx BW, Milaneschi Y, Lamers F, Vogelzangs N (2013) Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med 11:129

    Article  PubMed Central  PubMed  Google Scholar 

  15. Ladwig KH, Marten-Mittag B, Lowel H et al (2005) C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the monica-kora augsburg cohort study 1984–1998. Eur Heart J 26:2537–2542

    Article  CAS  PubMed  Google Scholar 

  16. Bruce EC, Musselman DL (2005) Depression, alterations in platelet function, and ischemic heart disease. Psychosom Med 67(Suppl 1):S34–S36

    Article  PubMed  Google Scholar 

  17. Halaris A (2013) Inflammation, heart disease, and depression. Curr Psychiatry Rep 15:400

    Article  PubMed  Google Scholar 

  18. Bondy B (2007) Common genetic factors for depression and cardiovascular disease. Dialogues Clin Neurosci 9:19–28

    PubMed Central  PubMed  Google Scholar 

  19. Hare DL, Toukhsati SR, Johansson P, Jaarsma T (2014) Depression and cardiovascular disease: a clinical review. Eur Heart J 35:1365–1372

    Article  PubMed  Google Scholar 

  20. Pogosova N, Saner H, Pedersen SS et al (2014) Psychosocial aspects in cardiac rehabilitation: from theory to practice. A position paper from the cardiac rehabilitation section of the european association of cardiovascular prevention and rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol [Epub ahead of print]

  21. Ladwig KH, Lederbogen F, Albus C et al (2014) Position paper on the importance of psychosocial factors in cardiology: update 2013. Ger Med Sci 12:Doc09

    PubMed Central  PubMed  Google Scholar 

  22. Whooley MA, Jonge P de, Vittinghoff E et al (2008) Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA 300:2379–2388

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Gehi A, Haas D, Pipkin S, Whooley MA (2005) Depression and medication adherence in outpatients with coronary heart disease: findings from the heart and soul study. Arch Intern Med 165:2508–2513

    Article  PubMed Central  PubMed  Google Scholar 

  24. Win S, Parakh K, Eze-Nliam CM et al (2011) Depressive symptoms, physical inactivity and risk of cardiovascular mortality in older adults: the cardiovascular health study. Heart 97:500–505

    Article  PubMed Central  PubMed  Google Scholar 

  25. Whooley MA (2006) Depression and cardiovascular disease: healing the broken-hearted. JAMA 295:2874–2881

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Tatoulis J, Psychosocial Risk Factors Expert Working Group of the National Heart Foundation of, A (2014) The rationale for depression screening in patients with coronary heart disease. On behalf of the psychosocial risk factors expert working group of the national heart foundation of Australia. J Psychosom Res 76:172–173

    Article  PubMed  Google Scholar 

  27. Elderon L, Smolderen KG, Na B, Whooley MA (2011) Accuracy and prognostic value of American Heart Association: recommended depression screening in patients with coronary heart disease: data from the heart and soul study. Circ Cardiovasc Qual Outcomes 4:533–540

    Article  PubMed  Google Scholar 

  28. Burton C, Simpson C, Anderson N (2013) Diagnosis and treatment of depression following routine screening in patients with coronary heart disease or diabetes: a database cohort study. Psychol Med 43:529–537

    Article  CAS  PubMed  Google Scholar 

  29. Albus C, Ladwig KH, Herrmann-Lingen C (2014) Psychocardiology: clinically relevant recommendations regarding selected cardiovascular diseases. Dtsch Med Wochenschr 139:596–601

    Article  CAS  PubMed  Google Scholar 

  30. DGPPN, BÄK, KBV et al (2009) S3-leitlinie/nationale versorgungsleitlinie unipolare depression-kurzfassung, 1. Aufl. DGPPN, ÄZQ, AWMF, Berlin

  31. Rutledge T, Redwine LS, Linke SE, Mills PJ (2013) A meta-analysis of mental health treatments and cardiac rehabilitation for improving clinical outcomes and depression among patients with coronary heart disease. Psychosom Med 75:335–349

    Article  PubMed  Google Scholar 

  32. Blumenthal JA, Babyak MA, O’Connor C et al (2012) Effects of exercise training on depressive symptoms in patients with chronic heart failure: the hf-action randomized trial. JAMA 308:465–474

    PubMed Central  CAS  PubMed  Google Scholar 

  33. Herring MP, Puetz TW, O’Connor PJ, Dishman RK (2012) Effect of exercise training on depressive symptoms among patients with a chronic illness: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 172:101–111

    Article  PubMed  Google Scholar 

  34. Blumenthal JA, Sherwood A, Babyak MA et al (2012) Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the upbeat (understanding the prognostic benefits of exercise and antidepressant therapy) study. J Am Coll Cardiol 60:1053–1063

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  35. Baumeister H, Hutter N, Bengel J (2011) Psychological and pharmacological interventions for depression in patients with coronary artery disease. Cochrane Database Syst Rev 9:CD008012 (Online)

    PubMed  Google Scholar 

  36. Dickens C, Cherrington A, Adeyemi I et al (2013) Characteristics of psychological interventions that improve depression in people with coronary heart disease: a systematic review and meta-regression. Psychosom Med 75:211–221

    Article  PubMed  Google Scholar 

  37. Whalley B, Rees K, Davies P et al (2011) Psychological interventions for coronary heart disease. Cochrane Database Syst Rev 8:CD002902 (Online)

    PubMed  Google Scholar 

  38. Glassman AH, O’Connor CM, Califf RM et al (2002) Sertraline treatment of major depression in patients with acute mi or unstable angina. JAMA 288:701–709

    Article  CAS  PubMed  Google Scholar 

  39. Mann JJ (2005) The medical management of depression. N Engl J Med 353:1819–1834

    Article  CAS  PubMed  Google Scholar 

  40. Zimmermann-Viehoff F, Kuehl LK, Danker-Hopfe H et al (2014) Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the heart and soul study. Psychol Med 44:2975–2984

    Article  CAS  PubMed  Google Scholar 

  41. Ziegelstein RC, Meuchel J, Kim TJ et al (2007) Selective serotonin reuptake inhibitor use by patients with acute coronary syndromes. Am J Med 120:525–530

    Article  CAS  PubMed  Google Scholar 

  42. Licht CM, Penninx BW, Geus EJ de (2012) Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study. Neuropsychopharmacology 37:2487–2495

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  43. Hanash JA, Hansen BH, Hansen JF et al (2012) Cardiovascular safety of one-year escitalopram therapy in clinically nondepressed patients with acute coronary syndrome: results from the depression in patients with coronary artery disease (decard) trial. J Cardiovasc Pharmacol 60:397–405

    Article  CAS  PubMed  Google Scholar 

  44. Jiang W, Velazquez EJ, Kuchibhatla M et al (2013) Effect of escitalopram on mental stress-induced myocardial ischemia: results of the remit trial. JAMA 309:2139–2149

    Article  CAS  PubMed  Google Scholar 

  45. Mazza M, Lotrionte M, Biondi-Zoccai G et al (2010) Selective serotonin reuptake inhibitors provide significant lower re-hospitalization rates in patients recovering from acute coronary syndromes: evidence from a meta-analysis. J Psychopharmacol 24:1785–1792

    Article  CAS  PubMed  Google Scholar 

  46. Berkman LF, Blumenthal J, Burg M et al (2003) Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the enhancing recovery in coronary heart disease patients (enrichd) randomized trial. JAMA 289:3106–3116

    Article  PubMed  Google Scholar 

  47. Xiong GL, Jiang W, Clare R et al (2006) Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting. Am J Cardiol 98:42–47

    Article  CAS  PubMed  Google Scholar 

  48. Weeke P, Jensen A, Folke F et al (2012) Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Clin Pharmacol Ther 92:72–79

    Article  CAS  PubMed  Google Scholar 

  49. Rieckmann N, Kronish IM, Shapiro PA et al (2013) Serotonin reuptake inhibitor use, depression, and long-term outcomes after an acute coronary syndrome: a prospective cohort study. JAMA Intern Med 173:1150–1151

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  50. Strubel T, Birkhofer A, Mossmer G, Forstl H (2010) SSRI – treatment and bleeding. What risks do we take? Nervenarzt 81:549–555

    Article  CAS  PubMed  Google Scholar 

  51. Kemp AH, Brunoni AR, Santos IS et al (2014) Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: an ELSA-Brasil Cohort Baseline Study. Am J Psychiatry [Epub ahead of print]

  52. Beach SR, Kostis WJ, Celano CM et al (2014) Meta-analysis of selective serotonin reuptake inhibitor-associated qtc prolongation. J Clin Psychiatry 75:e441–e449

    Article  PubMed  Google Scholar 

  53. Funk KA, Bostwick JR (2013) A comparison of the risk of qt prolongation among ssris. Ann Pharmacother 47:1330–1341

    Article  CAS  PubMed  Google Scholar 

  54. Lesperance F, Frasure-Smith N, Koszycki D et al (2007) Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the canadian cardiac randomized evaluation of antidepressant and psychotherapy efficacy (create) trial. JAMA 297:367–379

    Article  CAS  PubMed  Google Scholar 

  55. Kim JM, Bae KY, Stewart R, Jung BO et al (2015) Escitalopram treatment for depressive disorder following acute coronary syndrome: A 24-week double-blind, placebo-controlled trial. J Clin Psychiatry 76(1):62–68

    Article  PubMed  Google Scholar 

  56. Jiang W, Davidson JR (2005) Antidepressant therapy in patients with ischemic heart disease. Am Heart J 150:871–881

    Article  CAS  PubMed  Google Scholar 

  57. Taylor D (2008) Antidepressant drugs and cardiovascular pathology: a clinical overview of effectiveness and safety. Acta Psychiatr Scand 118:434–442

    Article  CAS  PubMed  Google Scholar 

  58. Pizzi C, Rutjes AW, Costa GM et al (2011) Meta-analysis of selective serotonin reuptake inhibitors in patients with depression and coronary heart disease. Am J Cardiol 107:972–979

    Article  CAS  PubMed  Google Scholar 

  59. Mavrides N, Nemeroff C (2013) Treatment of depression in cardiovascular disease. Depress Anxiety 30:328–341

    Article  CAS  PubMed  Google Scholar 

  60. O’Connor CM, Jiang W, Kuchibhatla M et al (2010) Safety and efficacy of sertraline for depression in patients with heart failure: Results of the sadhart-chf (sertraline against depression and heart disease in chronic heart failure) trial. J Am Coll Cardiol 56:692–699

    Article  Google Scholar 

  61. Hamer M, Batty GD, Marmot MG et al (2011) Anti-depressant medication use and c-reactive protein: results from two population-based studies. Brain Behav Immun 25:168–173

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  62. Reedt Dortland AK van, Giltay EJ, Veen T van et al (2010) Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use. Acta Psychiatr Scand 122:30–39

    Google Scholar 

  63. Roose SP (2003) Treatment of depression in patients with heart disease. Biol Psychiatry 54:262–268

    Article  CAS  PubMed  Google Scholar 

  64. Honig A, Kuyper AM, Schene AH et al (2007) Treatment of post-myocardial infarction depressive disorder: a randomized, placebo-controlled trial with mirtazapine. Psychosom Med 69:606–613

    Article  CAS  PubMed  Google Scholar 

  65. Roose SP, Dalack GW, Glassman AH et al (1991) Cardiovascular effects of bupropion in depressed patients with heart disease. Am J Psychiatry 148:512–516

    Article  CAS  PubMed  Google Scholar 

  66. Terhardt J, Lederbogen F, Feuerhack A et al (2013) Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine. Clin Neuropharmacol 36:198–202

    Article  CAS  PubMed  Google Scholar 

  67. Johnson EM, Whyte E, Mulsant BH et al (2006) Cardiovascular changes associated with venlafaxine in the treatment of late-life depression. Am J Geriatr Psychiatry 14:796–802

    Article  PubMed  Google Scholar 

  68. Schramm PJ, Poland RE, Rao U (2014) Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk. Eur Neuropsychopharmacol 24:207–214

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  69. Wernicke J, Lledo A, Raskin J et al (2007) An evaluation of the cardiovascular safety profile of duloxetine: findings from 42 placebo-controlled studies. Drug Saf 30:437–455

    Article  CAS  PubMed  Google Scholar 

  70. Ho JM, Gomes T, Straus SE et al (2014) Adverse cardiac events in older patients receiving venlafaxine: a population-based study. J Clin Psychiatry 75:e552–e558

    Article  CAS  PubMed  Google Scholar 

  71. Dubovsky SL, Warren C (2009) Agomelatine, a melatonin agonist with antidepressant properties. Expert Opin Investig Drugs 18:1533–1540

    Article  CAS  PubMed  Google Scholar 

  72. Dubovsky SL (2014) Pharmacokinetic evaluation of vortioxetine for the treatment of major depressive disorder. Expert Opin Drug Metab Toxicol 10:759–766

    Article  CAS  PubMed  Google Scholar 

  73. Katon W, Russo J, Lin EH et al (2012) Cost-effectiveness of a multicondition collaborative care intervention: a randomized controlled trial. Arch Gen Psychiatry 69:506–514

    Article  PubMed  Google Scholar 

  74. Katon WJ, Lin EH, Von Korff M et al (2010) Collaborative care for patients with depression and chronic illnesses. N Engl J Med 363:2611–2620

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  75. Gulliksson M, Burell G, Vessby B et al (2011) Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary prevention in uppsala primary health care project (suprim). Arch Intern Med 171:134–140

    Article  PubMed  Google Scholar 

  76. Albus C, Beutel ME, Deter HC et al (2011) A stepwise psychotherapy intervention for reducing risk in coronary artery disease (spirr-cad) – rationale and design of a multicenter, randomized trial in depressed patients with cad. J Psychosom Res 71:215–222

    Article  PubMed  Google Scholar 

  77. Albus C (2014) A stepwise psychotherapy intervention to reduce risk in coronary artery disease (spirr-cad) – results of a randomised, controlled multicentre trial. J Psychosom Res 76:495

    Article  Google Scholar 

  78. Roncella A, Pristipino C, Cianfrocca C et al (2013) One-year results of the randomized, controlled, short-term psychotherapy in acute myocardial infarction (step-in-ami) trial. Int J Cardiol 170:132–139

    Article  PubMed  Google Scholar 

  79. Freedland KE, Skala JA, Carney RM et al (2009) Treatment of depression after coronary artery bypass surgery: a randomized controlled trial. Arch Gen Psychiatry 66:387–396

    Article  PubMed  Google Scholar 

  80. Barth J, Paul J, Harter M, Bengel J (2005) Inpatient psychotherapeutic treatment for cardiac patients with depression in germany – short term results. Psychosoc Med 2:Doc04

    PubMed Central  PubMed  Google Scholar 

  81. Strik JJ, Honig A, Lousberg R et al (2000) Efficacy and safety of fluoxetine in the treatment of patients with major depression after first myocardial infarction: findings from a double-blind, placebo-controlled trial. Psychosom Med 62:783–789

    Article  CAS  PubMed  Google Scholar 

  82. McFarlane A, Kamath MV, Fallen EL et al (2001) Effect of sertraline on the recovery rate of cardiac autonomic function in depressed patients after acute myocardial infarction. Am Heart J 142:617–623

    Article  CAS  PubMed  Google Scholar 

  83. Mohapatra PK, Kar N, Kar GC, Behera M (2005) Effectiveness of sertraline in treatment of depression in a consecutive sample of patients with acute myocardial infarction: six month prospective study on outcome. Clin Pract Epidemiol Ment Health 1:26

    Article  PubMed Central  PubMed  Google Scholar 

  84. Davidson KW, Bigger JT, Burg MM et al (2013) Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: codiacs vanguard randomized controlled trial. JAMA Intern Med 173:997–1004

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  85. Kronish IM, Rieckmann N, Burg MM et al (2012) The effect of enhanced depression care on adherence to risk-reducing behaviors after acute coronary syndromes: findings from the copes trial. Am Heart J 164:524–529

    Article  PubMed Central  PubMed  Google Scholar 

  86. Davidson KW, Rieckmann N, Clemow L et al (2010) Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial. Arch Intern Med 170:600–608

    Article  PubMed Central  PubMed  Google Scholar 

  87. Donohue JM, Belnap BH, Men A et al (2014) Twelve-month cost-effectiveness of telephone-delivered collaborative care for treating depression following cabg surgery: a randomized controlled trial. Gen Hosp Psychiatry 36:453–459

    Article  PubMed  Google Scholar 

  88. Huffman JC, Mastromauro CA, Beach SR et al (2014) Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the management of sadness and anxiety in cardiology (mosaic) randomized clinical trial. JAMA Intern Med 174:927–935

    Article  CAS  PubMed  Google Scholar 

  89. Barley EA, Walters P, Haddad M et al (2014) The upbeat nurse-delivered personalized care intervention for people with coronary heart disease who report current chest pain and depression: a randomised controlled pilot study. PLoS One 9:e98704

    Article  PubMed Central  PubMed  Google Scholar 

  90. O’Neil A, Taylor B, Sanderson K et al (2014) Efficacy and feasibility of a tele-health intervention for acute coronary syndrome patients with depression: results of the „moodcare“ randomized controlled trial. Ann Behav Med 48:163–174

    Article  Google Scholar 

  91. O’Neil A, Taylor B, Hare DL et al (2014) Long-term efficacy of a tele-health intervention for acute coronary syndrome patients with depression: 12-month results of the moodcare randomized controlled trial. Eur J Prev Cardiol [Epub ahead of print]

  92. Morgan MA, Coates MJ, Dunbar JA et al (2013) The trueblue model of collaborative care using practice nurses as case managers for depression alongside diabetes or heart disease: a randomised trial. BMJ Open 3

  93. Coventry PA, Lovell K, Dickens C et al (2013) Update on the collaborative interventions for circulation and depression (coincide) trial: changes to planned methodology of a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease. Trials 14:136

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. A. Agorastos und F. Lederbogen geben an, dass kein Interessenkonflikt besteht. C. Otte hat in den letzten 2 Jahren Honorare für Beratungstätigkeit von Lundbeck, für wissenschaftliche Vorträge von Lundbeck und Servier und Reisekostenerstattung von Lundbeck und Servier erhalten.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Martini Str. 52, Geb. W37, 20246, Hamburg, Deutschland

    A. Agorastos

  2. Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Universität Heidelberg, Medizinische Fakultät Mannheim, Heidelberg, Deutschland

    F. Lederbogen

  3. Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité-Universitätsmedizin, Campus Benjamin Franklin, Berlin, Deutschland

    C. Otte

Authors
  1. A. Agorastos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Lederbogen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Otte
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Agorastos.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Agorastos, A., Lederbogen, F. & Otte, C. Behandlung der Depression bei koronarer Herzerkrankung. Nervenarzt 86, 375–387 (2015). https://doi.org/10.1007/s00115-014-4162-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-014-4162-z

Schlüsselwörter

Keywords

Search

Navigation