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Tolerance, suppression and the fetal allograft

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Abstract

In solid organ transplantation the recipient immune system recognises foreign alloantigens expressed by the graft. This results in an immune attack of the transplanted organ leading to rejection, which can be prevented only by therapeutic immunosuppression. During pregnancy the fetus should also be rejected by the maternal immune system, since it expresses antigens derived from the father. Whilst the immune system retains the ability to respond to foreign antigen, tolerance mechanisms ensure that inappropriate responses against self-antigen are prevented. Maternal immune aggression directed against the fetus is partly inhibited by peripheral tolerance mechanisms that act locally to deplete cells capable of attacking the fetus. Other local mechanisms inhibit the pathways that cause tissue damage after immune activation. Recent studies in mice and humans indicate that the maternal immune system undergoes a more systemic change that promotes materno-fetal tolerance. Naturally occurring regulatory T cells, which are commonly associated with maintaining tolerance to self-antigens, can also suppress maternal allo-responses targeted against the fetus. We review the mechanisms that mediate materno-fetal tolerance, with particular emphasis on changes in regulatory T cell function during pregnancy and discuss their implications.

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Abbreviations

CTLA :

Cytotoxic T lymphocyte associated antigen

GITR :

Glucocorticoid-induced tumour necrosis factor receptor family related

HLA :

Human leukocyte antigen

IDO :

Indoleamine 2,3-dioxygenase

IL :

Interleukin

IPEX :

Immune dysregulation, poly-endocrinopathy, enteropathy, X-chromosome linked

NK :

Natural killer

TGF :

Transforming growth factor

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Authors and Affiliations

  1. Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge, CB2 2QH, UK

    Varuna R. Aluvihare, Marinos Kallikourdis & Alexander G. Betz

  2. Department of Medicine, Addenbrooke’s NHS Trust, Hills Road, Cambridge, CB2 2YH, UK

    Varuna R. Aluvihare

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  1. Varuna R. Aluvihare
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  2. Marinos Kallikourdis
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Correspondence to Varuna R. Aluvihare.

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Aluvihare, V.R., Kallikourdis, M. & Betz, A.G. Tolerance, suppression and the fetal allograft. J Mol Med 83, 88–96 (2005). https://doi.org/10.1007/s00109-004-0608-2

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