Zusammenfassung
Die Problematik von Hypoglykämien umfasst ein multifaktorielles Geschehen, bei dem physiologische Parameter und das Verhalten der betroffenen Patienten im Rahmen der Selbstkontrolle miteinender interagieren. Insbesondere die zunehmende Therapie mit Insulin und nahe-normoglykämische Blutglukoseeinstellung haben die Hypoglykämie zu einem bedeutenden Problem im Rahmen der diabetesbedingten Akutkomplikationen werden lassen. Eine frühzeitige Diagnostik und Therapieeinleitung sind daher unerlässlich um die erhöhte Mortalität zu senken. Neben der Akuttherapie der Hypoglykämie umfassen die erweiterten therapeutischen Maßnahmen die Modifikation der Diabetestherapie, Patientenschulungen sowie ein spezielles Hypoglykämiewahrnehmungstraining.
Abstract
Hypoglycemia is a multifactorial problem that is caused by the interaction of numerous variables such as a individual pathophysiological response, treatment aspects and self control. In particular, the increasing use of intensified insulin therapy and thus the goal of normoglycemia has made hypoglycaemia to become a major hazard among the acute complications of diabetes mellitus. Early diagnosis and treatment is thus mandatory to reduce the increased morbidity and mortality of hypoglycaemia. Among the acute therapy of hypoglycaemia treatment includes a modification of diabetes therapy, patient education and a special training of hypoglycaemia awareness.
Literatur
Laing SP, Swerdlow AJ, Slater SD et al. (1999) The British Diabetic Association Cohort Study, II: cause-specific mortality in patients with insulin-treated diabetes mellitus. Diabet Med 16: 466–471
The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977–986
UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837–853
Cryer PE (2002) Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia 45: 937–948
Johnson ES, Koepsell TD, Reiber G, Stergachis A, Platt R (2002) Increasing incidence of serious hypoglycemia in insulin users. J Clin Epidemiol 55: 253–259
Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J (1993) Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42: 1233–1237
Heller SR, Cryer PE (1991) Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes 40: 223–226
U.K. Prospective Diabetes Study Group (1995) U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44: 1249–1258
Leese GP, Wang J, Broomhall J et al. (2003) Freyuency of severe hyperglycemia requiring emergency treatment in type 1 and type 2 diabetes. Diabetes Care 26: 1176–1180
Levy CJ, Kinsley BT, Bajaj M, Simonson DC (1998) Effect of glycemic control on glucose counterregulation during hypoglycemia in NIDDM. Diabetes Care 21: 1330–1338
Stiefelhagen P (2002) Hypoglycemia risk. Why elderly patients are especially at risk. MMW Fortschr Med 144: 10
Baker D, Evans M, Cryer P, Sherwin R (1997) Hypoglycaemia and glucose sensing. Diabetologia 40: B83–B88
Bolli GB, Pampanelli S, Porcellati F, Fanelli CG (2002) Recovery and prevention of hypoglycaemia unawareness in type 1 diabetes mellitus. Diabetes Nutr Metab 15: 402–409
Hermanns N, Kulzer B, Maier B, Kubiak T, Haak T (2002) Risikoindikatoren für das Auftreten schwerer Hypoglykämien bei Patienten mit Typ-1-Diabetes mellitus. Diabetes Stoffw 11: 145–149
Muhlhauser I, Overmann H, Bender R, Bott U, Berger M (1998) Risk factors of severe hypoglycaemia in adult patients with Type I diabetes—a prospective population based study. Diabetologia 41: 1274–1282
Allen C, LeCaire T, Palta M et al. (2001) Risk factors for frequent and severe hypoglycemia in type 1 diabetes. Diabetes Care 24: 1878–1881
Cryer PE, Davis SN, Shamoon H (2003) Hypoglycemia in diabetes. Diabetes Care 26: 1902–1912
Cryer PE (2002) The pathophysiology of hypoglycaemia in diabetes. Diabetes Nutr Metab 15: 330–333
Heller SR (1999) Diabetic hypoglycaemia. Baillieres Best Pract Res Clin Endocrinol Metab 13: 279–294
Lobmann R, Lehnert H. (1997) Notfallsituation Hypoglykämie. Notfallmedizin 510–513
Holstein A, Plaschke A, Schlieker H, Egberts EH (2002) Structural and process quality in the management of diabetic emergencies in Germany. Int J Qual Health Care 14: 33–38
McAulay V, Deary IJ, Frier BM (2001) Symptoms of hypoglycaemia in people with diabetes. Diabetes Med 18: 690–705
Del Prato S, Aragona M, Coppelli A (2002) Sulfonylureas and hypoglycaemia. Diabetes Nutr Metab 15: 444–450
Gold AE, MacLeod KM, Frier BM (1994) Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia. Diabetes Care 17: 697–703
Clarke WL, Gonder-Frederick LA, Richards FE, Cryer PE (1991) Multifactorial origin of hypoglycemic symptom unawareness in IDDM. Association with defective glucose counterregulation and better glycemic control. Diabetes 40: 680–685
Heller SR, Amiel SA, Mansell P (1999) Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy. U.K. Lispro Study Group. Diabetes Care 22: 1607–1611
Brunelle BL, Llewelyn J, Anderson JH, Gale EA, Koivisto VA (1998) Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes. Diabetes Care 21: 1726–1731
Home PD, Lindholm A, Hylleberg B, Round P (1998) Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group. Diabetes Care 21: 1904–1909
Ratner RE, Hirsch IB, Neifing JL et al. (2000) Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes. U.S. Study Group of Insulin Glargine in Type 1 Diabetes. Diabetes Care 23: 639–643
Yki-Jarvinen H, Dressler A, Ziemen M (2000) Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group. Diabetes Care 23: 1130–1136
Hermansen K, Madsbad S, Perrild H, Kristensen A, Axelsen M (2001) Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: a randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy. Diabetes Care 24: 296–301
Holstein A, Plaschke A, Egberts EH (2001) Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide. Diabetes Metab Res Rev 17: 467–473
Holstein A, Plaschke A, Hammer C, Egberts EH (2003) Characteristics and time course of severe glimepiride- versus glibenclamide-induced hypoglycaemia. Eur J Clin Pharmacol 59: 91–97
Klein J, Ott V, Schutt M, Klein HH (2002) Recurrent hypoglycaemic episodes in a patient with Type 2 diabetes under fibrate therapy. J Diabetes Complications 16: 246–248
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Lobmann, R., Lehnert, H. Hypoglykämie. Internist 44, 1275–1282 (2003). https://doi.org/10.1007/s00108-003-1052-z
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DOI: https://doi.org/10.1007/s00108-003-1052-z