Zusammenfassung
Hintergrund
Der Einsatz von medizinischer Kompressionstherapie in der Therapie phlebologischer Krankheitsbilder findet breite Anwendung. Mehrlagen- und Mehrkomponentenkompressionsbandagen und medizinische Kompressionsstrümpfe bewirken die Entstauung der Extremität und bessern die klinische Symptomatik. Es wird die Evidenz für den Einsatz der medizinischen Kompressionstherapie bei chronischer venöser Insuffizienz, bei entzündlichen Dermatosen und nach phlebochirurgischen Eingriffen und Interventionen aufgezeigt.
Material und Methoden
Die Übersichtsarbeit gibt eine systemische Darstellung des evidenzbasierten Einsatzes von Kompression. Aktuelle Literatur, insbesondere Leitlinien wurden durchsucht und die Indikationen für die Kompressionstherapie dargestellt.
Ergebnisse
Es besteht eine hohe Evidenz in der Therapie des Ulcus cruris venosum und in der Prophylaxe des Ulkusrezidivs. Der Einsatz nach interventionellen und operativen Eingriffen am Venensystem ist gängige Praxis, die Wirksamkeit kann jedoch nicht durch Studien belegt werden. Ebenso auf Empirie, nicht durch Studien untermauert, basiert die Anwendung der Kompression bei kutanen entzündlichen Erkrankungen wie Erythema nodosum, Pyoderma gangraenosum, Necrobiosis lipoidica, kutane leukozytoklastische Angiitis und Psoriasis der Extremitäten.
Abstract
Background
Medical compression therapy is widely used to treat phlebologic diseases. Compression bandages as well as compression stockings are used. Compression has been identified to be an effective conservative therapy for the healing of venous ulcers and other indications. Thus, the evidence for the use of medical compression therapy and for which indications is presented.
Materials and methods
Review and systematic presentation of the evidence-based use of compression. The current literature, guidelines, and consensus statements were searched and the indications for compression therapy are presented.
Results
There is a high level of evidence that compression therapy is effective to heal venous ulcers and to prevent recurrent ulcers. The use of compression bandages and hosiery after interventional and surgical procedures for varicose veins is based on experience but not on randomized controlled trials. According to clinical experience, the healing of inflammatory skin diseases (e.g., erythema nodosum, pyoderma gangrenosum, necrobiosis lipoidica, cutaneous leukocytoclastic vasculitis, and psoriasis of the extremities) is supported by compression therapy. Compression therapy in patients suffering from venous ulcers is highly recommended.
Literatur
Rabe E et al (2003) Bonner Venenstudie der Deutschen Gesellschaft für Phlebologie. Phlebologie 32(1):1–14
Valencia IC et al (2001) Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol 44(3):401–424
Leitlinie, A. W. M. F. „Diagnostik und Therapie des Ulcus cruris venosum.“ AWMF Online (2008): 037-009.
O’Donnell TF et al (2014) Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg 60(2 Suppl):3S–59S
Labropoulos N et al (2009) Secondary chronic venous disease progresses faster than primary. J Vasc Surg 49(3):704–710
Jünger M et al (2000) Microcirculatory dysfunction in chronic venous insufficiency (CVI). Microcirculation 7:S1
Klyscz T et al (1997) Einfluß einer Kompressionstherapie auf die Mikrozirkulation der Haut bei Patienten mit chronischer Veneninsuffizienz (CVI). Hautarzt 48(11):806–811
Mauck KF et al (2014) Comparative systematic review and meta-analysis of compression modalities for the promotion of venous ulcer healing and reducing ulcer recurrence. J Vasc Surg 60(2):71S–90S
Rubin JR et al (1990) Unna’s boot vs polyurethane foam dressings for the treatment of venous ulceration: a randomized prospective study. Arch Surg 125(4):489–490
Wong IKY et al (2012) Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. J Eur Acad Dermatol Venereol 26(1):102–110
Konschake W et al (2017) Compression in the treatment of chronic venous insufficiency: efficacy depending on the length of the stocking. Clin Hemorheol Microcirc 64(3):425–434. doi:10.3233/ch-168122
Jünger M et al (2004) Efficacy and tolerability of an ulcer compression stocking for therapy of chronic venous ulcer compared with a below-knee compression bandage: results from a prospective, randomized, multicentre trial. Curr Med Res Opin 20(10):1613–1623
Rabe E et al (2017) Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology. doi:10.1177/0268355516689631
Clarke-Moloney M et al (2014) Randomised controlled trial comparing European standard class 1 to class 2 compression stockings for ulcer recurrence and patient compliance. Int Wound J 11(4):404–408
Riebe H et al (2016) Advantages and disadvantages of graduated and inverse graduated compression hosiery in patients with chronic venous insufficiency and healthy volunteers: a prospective, mono-centric, blinded, open randomised, controlled and cross-over trial. Phlebology. doi:10.1177/0268355516682885
Altintas AA, Gehl B, Aust MC, Meyer-MArcotty M, Altintas MA (2011) Impact of compression therapy on local microcirculation and histomorphology in venous leg ulcers. Phlebologie 40:9–14
Beidler SK, Douillet CD, Berndt DF, Keagy BA, Rich PB, Marston WA (2009) Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy. J Vasc Surg 49:1013–1020
Beidler SK, Douillet CD, Berndt DF, Keagy BA, Rich PB, Marston WA (2008) Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy. Wound Repair Regen 16:642–648
Asemota E, Chang YC, Goldberg LJ (2016) Innovative management of recalcitrant dissecting cellulitis with compression therapy. JAMA Dermatol 152:1280–1281
Savoia F, Odorici G, Tengattini V, Patrizi A, Gaddoni G (2013) Elephantasis nostras verrucosa and psoriasis: only a coincidence? Int J Low Extrem Wounds 12:320–321
Wakamatsu K, Naniwa K, Hagiya Y, Ichimiya M, Muto M (2010) Psoriasis verrucosa. J Dermatol 37:1060–1062
Ludwig RJ, Werner RJ, Winker W, Boehncke WH, Wolter M, Kaufmann R (2006) Chronic venous insufficiency – a potential trigger for localized scleroderma. J Eur Acad Dermatol Venereol 20:96–99
Valesky EM, Kaufmann R, Meissner M (2013) Special indications for negative pressure wound therapy in dermatologic surgery. Hautarzt 64(8):585–591
Webster J, Scuffham P, Stankiewicz M, Chaboyer WP (2014) Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention. Cochrane Database Syst Rev. doi:10.1002/14651858.cd009261.pub3
Suh H, Lee AY, Park EJ, Hong JP (2016) Negative pressure wound therapy on closed surgical wounds with dead space: animal study using a swine model. Ann Plast Surg 76:717–722
Brent B (1978) The role of pressure therapy in management of earlobe keloids: preliminary report of a controlled study. Ann Plast Surg 1:579–581
Caglayan Y et al (2010) Mechanical receptor-related mechanisms in scar management: a review and hypothesis. Plast Reconstr Surg 126(2):426–434
Tejiram S, Zhang J, Travis TE, Carney BC, Alkhalil A, Moffatt LT, Johnson LS, Shupp JW (2016) Compression therapy affects collagen type balance in hypertrophic scar. J Surg Res 201:299–305
Ogawa R, Akaishi S (2016) Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis – Keloids and hypertrophic scars may be vascular disorders. Med Hypotheses 96:51–60
Ogawa R (2017) Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 18(3):606. doi:10.3390/ijms18030606
Leitlinie Phlebolgischer Kompressionsverband PKV; 01.06.2009; AWMF-Registernummer 037-005.
Leitlinie Sklerotherapie
Weiss RA, Sadick NS, Goldman MP, Weiss MA (1999) Post-sclerotherapy compression: controlled comparative study of duration of compression and its effects on clinical outcome. Dermatol Surg 25:105–108
Kern P, Ramelet AA, Wütschert R, Hayoz D (2007) Compression after sclerotherapy for telangiectasias and reticular leg veins. A randomized controlled study. J Vasc Surg 45:1212–1216
Goldman PM, Beaudoing D, Marley W et al (1990) Compression in the treatment of leg teleangiectasia: a preliminary report. J Dermatol Surg Oncol 16:322–325
Stanley PRW, Bickerton DR, Campbell WB (1991) Injection sclerotherapy for varicose veins a comparison of materials for applying local compression. Phlebology 6:37–39
Biswas S, Clark A, Shields DA (2007) Randomised clinical trial of the duration of compression therapy after varicose vein surgery. Eur J Vasc Endovasc Surg 33:631–637
Houtermans-Auckel JP, van Rossum E, Teijink JAW, Dahlmans AAW, Eussen EFB, Nicolaı SPA, Welten RJTJ (2009) To wear or not to wear compression stockings after varicose vein stripping: a randomised controlled trial. Eur J Vasc Endovasc Surg 38:387–391
Huang TW, Chen SL, Bai CH, Wu CH, Tam KW (2013) The optimal duration of compression therapy following varicose vein surgery: a meta-analysis of randomized controlled trials. Eur J Vasc Endovasc Surg 45:397–402
Ayo D, Blumberg SN, Rockman CR, Sadek M, Cayne N, Adelman M, Kabnick L, Maldonado T, Berland T (2017) Compression versus no compression after endovenous ablation of the great saphenous vein: a randomized controlled trial. Ann Vasc Surg 38:72–77. doi:10.1016/j.avsg.2016.08.008
Bakker NA, Schieven LW, Bruins RMG, van den Berg M, Hissink RJ (2013) Compression stockings after endovenous laser ablation of the great saphenous vein: a prospective randomized controlled trial. Eur J Vasc Endovasc Surg 46:588–592
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W. Konschake, E. Valesky, H. Stege und M. Jünger geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
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Konschake, W., Valesky, E., Stege, H. et al. Evidenz der Kompressionstherapie. Hautarzt 68, 625–631 (2017). https://doi.org/10.1007/s00105-017-3999-z
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DOI: https://doi.org/10.1007/s00105-017-3999-z
Schlüsselwörter
- Medizinische Kompressionstherapie
- Evidenz
- Chronische venöse Insuffizienz
- Ulcus cruris venosum
- Chirurgie der Varikose