Skip to main content
Log in

Hauterkrankungen beim geriatrischen Patienten

Epidemiologische Daten

Skin diseases in geriatric patients

Epidemiologic data

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

In den letzten Jahren hat die Inzidenz altersassoziierter Hauterkrankungen, insbesondere entzündlicher Dermatosen, Autoimmunerkrankungen, Tumoren und paraneoplastischer Syndrome progredient zugenommen. Diese bedeutende Entwicklung liegt in einer erhöhten Früh- und lebenslangen UV-Exposition sowie im demographischen Alterungsprozess begründet. Um den demographischen Wandel zukünftig als Chance zu erleben, sind ein besseres Verständnis der Pathomechanismen dieser speziellen Erkrankungen sowie eine frühzeitige Diagnose und Therapie essenziell. Darüber hinaus muss die breite Öffentlichkeit für diesen Themenkomplex sensibilisiert und der Patient individuell aufgeklärt werden. Diese Strategie beinhaltet frühzeitige, prophylaktische Maßnahmen und eine konsequente Überwachung von Hochrisikogruppen. In der vorliegenden Arbeit wird die erwähnte Beziehung zwischen Hautalterung und der Epidemiologie assoziierter Erkrankungen unter Berücksichtigung der Risikofaktoren im Detail dargestellt.

Abstract

The incidence of skin diseases more common in older patients, e.g. inflammatory and autoimmune diseases, benign and malignant tumors and paraneoplastic syndromes, is increasing worldwide rapidly mainly due to early or lifelong UV-overexposure and to an aging population. In order to transform this demographic change into a chance a better understanding of the pathomechanisms of these diseases, an early diagnosis and therapy are essential steps. In addition, a joint effort to raise public awareness, patient education, preventive measures and consistent monitoring of high-risk groups is of great importance. In this article, the relationship between aging and associated skin diseases will be presented with a particular focus on the epidemiology and risk factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. United Nations (Hrsg) (2007) World population prospects the 2006 revision highlights. Department of economic and social affairs population division. United Nations Publications, New York

  2. Osiewacz HD (1997) Genetic regulation of aging. J Mol Med 75(10):715–727

    Article  PubMed  CAS  Google Scholar 

  3. Jazwinski SM (1999) The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity. Neurobiol Aging 20(5):471–478

    Article  PubMed  CAS  Google Scholar 

  4. Oeppen J, Vaupel JW (2002) Demography. Broken limits to life expectancy. Science 296(5570):1029–1031

    Article  PubMed  CAS  Google Scholar 

  5. Fisher GJ, Kang S et al (2002) Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138(11):1462–1470

    Article  PubMed  CAS  Google Scholar 

  6. Evelson P, Ordonez CP et al (1997) Oxidative stress and in vivo chemiluminescence in mouse skin exposed to UVA radiation. J Photochem Photobiol 38(2–3):215–219

    Google Scholar 

  7. Podda M, Traber MG et al (1998) UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin. Free Radic Biol Med 24(1):55–65

    Article  PubMed  CAS  Google Scholar 

  8. Kohen R (1999) Skin antioxidants: their role in aging and in oxidative stress-new approaches for their evaluation. Biomed Pharmacother 53(4):181–192

    Article  PubMed  CAS  Google Scholar 

  9. Rittie L, Fisher GJ (2002) UV-light-induced signal cascades and skin aging. Ageing Res Rev 1(4):705–720

    Article  PubMed  CAS  Google Scholar 

  10. Uitto J (1986) Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 4(3):433–446

    PubMed  CAS  Google Scholar 

  11. Ashcroft GS, Herrick SE et al (1997) Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol 183(2):169–176

    Article  PubMed  CAS  Google Scholar 

  12. Eaglstein WH (1989) Wound healing and aging. Clin Geriatr Med 5(1):183–188

    PubMed  CAS  Google Scholar 

  13. Zouboulis CC, Makrantonaki E (2011) Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol 29:3–14

    Article  PubMed  Google Scholar 

  14. Arnaud L, Mathian A, Boddaert J, Amoura Z (2012) Late-onset systemic lupus erythematosus: epidemiology, diagnosis and treatment. Drugs Aging 29(3):181–189

    Article  PubMed  CAS  Google Scholar 

  15. Lalani S, Pope J, Leon F de et al (2010) Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study. J Rheumatol 37(1):38–44

    Article  PubMed  Google Scholar 

  16. Boddaert J, Huong DL, Amoura Z et al (2004) Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore) 83(6):348–359

    Google Scholar 

  17. Ingen-Housz-Oro S, Alexandre M, Le Roux-Villet C et al (2012) Pemphigus in elderly adults: clinical presentation, treatment, and prognosis. J Am Geriatr Soc 60(6):1185–1187

    Article  PubMed  Google Scholar 

  18. Langan SM, Smeeth L, Hubbard R et al (2008) Bullous pemphigoid and pemphigus vulgaris – incidence and mortality in the UK: population based cohort study. BMJ 337:a180

    Article  PubMed  CAS  Google Scholar 

  19. Kwon HH, Kwon IH, Youn JI (2012) Clinical study of psoriasis occurring over the age of 60 years: Is elderly-onset psoriasis a distinct subtype? Int J Dermatol 51(1):53–58

    Article  PubMed  Google Scholar 

  20. Ferrándiz C, Pujol RM, García-Patos V et al (2002) Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol 46(6):867–873

    Article  PubMed  Google Scholar 

  21. Piérard-Franchimont C, Piérard GE (2012) Drug-related psoriasis. Rev Med Liege 67(3):139–142

    PubMed  Google Scholar 

  22. Bansal R, Tutrone WD, Weinberg JM (2002) Viral skin infections in the elderly: diagnosis and management. Drugs Aging 19(7):503–514

    Article  PubMed  Google Scholar 

  23. Weinberg JM, Scheinfeld NS (2003) Cutaneous infections in the elderly: diagnosis and management. Dermatol Ther 16(3):195–205

    Article  PubMed  Google Scholar 

  24. Weinberg JM, Vafaie J, Scheinfeld NS (2010) Skin infections in the elderly. Dermatol Clin 22(1):51–61

    Google Scholar 

  25. Taute B-M (2010) Chronische venöse Insuffizienz. Internist 51:351–358

    Article  PubMed  Google Scholar 

  26. Rabe E, Guex JJ, Puskas A et al (2012) Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein Consult Program. Int Angiol 31(2):105–115

    PubMed  CAS  Google Scholar 

  27. Carpentier PH, Maricq HR, Biro C et al (2004) Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: a population-based study in France. J Vasc Surg 40:650–659

    Article  PubMed  Google Scholar 

  28. Fowkes FG, Evans CJ, Lee AJ (2001) Prevalence and risk factors of chronic venous insufficiency. Angiology 52(1):5–15

    Article  Google Scholar 

  29. Jawien A, Grzela T, Ochwat A (2003) Prevalence of chronic venous insufficiency in men and women in Poland: multicentre cross-sectional study in 40,095 patients. Phlebology 18:110–122

    Article  Google Scholar 

  30. Lozano FS, Masegosa A, Alvarez J et al (2009) Occurrence and management of chronic venous disease in primary health care in Spain. A comparison of DETECT-2006 with DETECT-2000. Int Angiol 28:62–67

    PubMed  CAS  Google Scholar 

  31. Rabe E, Pannier-Fischer F, Bromen K et al (2003) Bonner Venenstudie der Deutschen Gesellschaft für Phlebologie – Epidemiologische Untersuchung zur Frage der Häufigkeit und Ausprägung von chronischen Venenkrankheiten in der städtischen und ländlichen Wohnbevölkerung. Phlebologie 32:1–14

    Google Scholar 

  32. Eklöf B, Perrin M, Delis KT et al (2009) Updated terminology of chronic venous disorders: the VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg 49:498–501

    Article  PubMed  Google Scholar 

  33. Nicolaides AN, Allegra C, Bergan J et al (2008) Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. Int Angiol 27:1–59

    PubMed  CAS  Google Scholar 

  34. Kottner J, Wilborn D, Dassen T, Lahmann N (2009) The trend of pressure ulcer prevalence rates in German hospitals: results of seven crosssectional studies. J Tissue Viability 18:36–46

    Article  PubMed  Google Scholar 

  35. Theisen S, Drabik A, Stock S (2011) Pressure ulcers in older hospitalised patients and its impact on length of stay: a retrospective observational study. J Clin Nurs 21:380–387

    Article  PubMed  Google Scholar 

  36. Iizaka S, Okuwa M, Sugama J, Sanada H (2010) The impact of malnutrition and nutrition-related factors on the development and severity of pressure ulcers in older patients receiving home care. Clinical Nutrition 29:47–53

    Article  PubMed  Google Scholar 

  37. Goldberg LH, Mamelak AJ (2010) Review of actinic keratosis. Part I: etiology, epidemiology and clinical presentation. J Drugs Dermatol 9:1125–1132

    PubMed  Google Scholar 

  38. Schmitt JV, Miot HA (2012) Actinic keratosis: a clinical and epidemiological revision. An Bras Dermatol 87:425–434

    Article  PubMed  Google Scholar 

  39. Traianou A, Ulrich M, Apalla Z et al (2012) Risk factors for actinic keratosis in eight European centres: a case-control study. Br Assoc Dermatologists 167(2):36–42

    Article  Google Scholar 

  40. Bath-Hextall F, Leonardi-Bee J, Smith C et al (2007) Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study. Int J Cancer 121:2105–2108

    Article  PubMed  CAS  Google Scholar 

  41. Flohil SC, Vries E de, Neumann HAM et al (2011) Incidence, prevalence, and future trends of primary basal cell carcinoma in the Netherlands. Acta Derm Venereol 91:24–30

    PubMed  Google Scholar 

  42. Birch-Johansen F, Jensen A, Mortensen L et al (2010) Trends in the incidence of nonmelanoma skin cancer in Denmark 1978–2007: rapid incidence increase among young Danish women. Int J Cancer 127:2190–2198

    Article  PubMed  CAS  Google Scholar 

  43. Karagas MR, Greenberg ER, Spencer SK et al (1999) Increase in incidence rates of basal cell and squamous cell skin cancer in New Hampshire, USA. New Hampshire Skin Cancer Study Group. Int J Cancer 81:555–559

    Article  PubMed  CAS  Google Scholar 

  44. Buettner PG, Raasch BA (1998) Incidence rates of skin cancer in Townsville, Australia. Int J Cancer 78:587–593

    Article  PubMed  CAS  Google Scholar 

  45. Chinem VP, Miot HA (2011) Epidemiology of basal cell carcinoma. An Bras Dermatol 86:292–305

    Article  PubMed  Google Scholar 

  46. Trakatelli M, Ulrich C, Marmol V del et al (2007) Epidemiology of nonmelanoma skin cancer (NMSC) in Europe: accurate and comparable data are needed for effective public health monitoring and interventions. Br J Dermatol 156(3):1–7

    Article  PubMed  Google Scholar 

  47. De Vries E, Micallef R, Brewster DH et al (2012) EPIDERM Group. Population-based estimates of the occurrence of multiple vs first primary basal cell carcinomas in 4 European regions. Arch Dermatol 148:347–354

    Article  Google Scholar 

  48. Flohil SC, Proby CM, Forrest AD et al (2012). Br J Dermatol 167(2):22–28

    Article  PubMed  Google Scholar 

  49. Schwartzberg JB, Elgart GW, Romanelli P et al (2005) Accuracy and predictors of basal cell carcinoma diagnosis. Dermatol Surg 31:534–537

    Article  PubMed  CAS  Google Scholar 

  50. Samarasinghe V, Madan V (2012) Nonmelanoma skin cancer. J Cutan Aesthet Surg 5:3–10

    Article  PubMed  Google Scholar 

  51. Haliasos EC, Kerner M, Jaimes N et al (2012) Dermoscopy for the pediatric dermatologist, Part II: dermoscopy of genetic syndromes with cutaneous manifestations and pediatric vascular lesions. Pediatr Dermatol doi: 10.1111/j.1525-1470.2012.01874.x (Epub ahead of print)

    Google Scholar 

  52. Bergman R, Mercer A, Indelman M et al (2012) KID syndrome: histopathological, immunohistochemical and molecular analysis of precancerous and cancerous skin lesions. Br J Dermatol 166(2):455–457

    Article  PubMed  CAS  Google Scholar 

  53. Grossman D, Leffell DJ (2012) Squamous cell carcinoma. In: Goldsmith LA, Katz SI, Gilchrest BA et (Hrsg) Fitzpatrick’s dermatology in general medicine, 8 Aufl. McGraw-Hill, Columbus, S 1283–1294

  54. Lee LA, Huang CG, Liao CT et al (2012) Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. PLoS One 7:e40767

    Article  PubMed  CAS  Google Scholar 

  55. Marques-Silva L, Farias LC, Fraga CA et al (2012) HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients. Oncol Lett 3:945–949

    PubMed  CAS  Google Scholar 

  56. Arron ST, Jennings L, Nindl I et al (2011) Viral Working Group of the International Transplant Skin Cancer Collaborative (ITSCC) & Skin Care in Organ Transplant Patients, Europe (SCOPE). Viral oncogenesis and its role in nonmelanoma skin cancer. Br J Dermatol 164:1201–1213

    Article  PubMed  Google Scholar 

  57. Andersson K, Michael KM, Luostarinen T et al (2012) Prospective study of human papillomavirus seropositivity and risk of nonmelanoma skin cancer. Am J Epidemiol 175:685–695

    Article  PubMed  Google Scholar 

  58. Allam E, Zhang W, Al-Shibani N et al (2011) Effects of cigarette smoke condensate on oral squamous cell carcinoma cells. Arch Oral Biol 56:1154–1161

    Article  PubMed  CAS  Google Scholar 

  59. Ritchie SA, Patel MJ, Miller SJ (2012) Therapeutic options to decrease actinic keratosis and squamous cell carcinoma incidence and progression in solid organ transplant recipients: a practical approach. Dermatol Surg 38(10):1604–1621

    Article  PubMed  CAS  Google Scholar 

  60. Rüegg CP, Graf N, Mühleisen B et al (2012) Squamous cell carcinoma of the skin induces considerable sustained cost of care in organ transplant recipients. J Am Acad Dermatol [Epub ahead of print]

  61. Chamberlain AJ, Fritschi L, Giles GG et al (2002) Nodular type and older age as the most significant associations of thick melanoma in Victoria, Australia. Arch Dermatol 138:609–614

    Article  PubMed  Google Scholar 

  62. Lasithiotakis KG, Leiter U, Gorkievicz R et al (2006) The incidence and mortality of cutaneous melanoma in southern Germany: trends by anatomic site and pathologic characteristics, 1976–2003. Cancer 107:1331–1339

    Article  PubMed  Google Scholar 

  63. Chang AE, Karnell LH, Menck HR (1998) The national cancer data base report on cutaneous and noncutaneous melanoma: a summary of 84.836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 83:1664–1678

    Article  PubMed  CAS  Google Scholar 

  64. Morris BT, Sober AJ (1986) Cutaneous malignant melanoma in the older patient. Dermatol Clin 4:473–480

    PubMed  CAS  Google Scholar 

  65. Keefe M, White JE, Perkins P (1990) Nodular melanomas in the over 50 age group the next target for health education. Br J Dermatol 123(37):59

    Article  Google Scholar 

  66. Kolb GF (2002) Bösartige Erkrankungen im Alter – Der alte Tumorpatient. Internist 43:959–964

    Article  PubMed  CAS  Google Scholar 

  67. Wolff H (2001) Cutaneous paraneoplastic syndromes. Hautarzt 52(2):159–172

    Article  PubMed  CAS  Google Scholar 

  68. Stone SP, Buescher LS (2005) Life-threatening paraneoplastic cutaneous syndromes. Clin Dermatol 23(3):301–306

    Article  PubMed  Google Scholar 

  69. Abreu Velez AM, Howard MS (2010) Diagnosis and treatment of cutaneous paraneoplastic disorders. Dermatol Ther 23(6):662–675

    Article  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C.C. Zouboulis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Makrantonaki, E., Liakou, A., Eckardt, R. et al. Hauterkrankungen beim geriatrischen Patienten. Hautarzt 63, 938–946 (2012). https://doi.org/10.1007/s00105-012-2466-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-012-2466-0

Schlüsselwörter

Keywords

Navigation