Summary
A rise in ambient temperature stimulates the absorption of soluble, rapid-acting insulin. In the present study, the effect of intensive heat (Finnish sauna) on the absorption of amorphous insulin from a subcutaneous injection site in eight patients with type I diabetes was examined. The rate of absorption was determined by external measurement of the disappearance rate of125I-labelled intermediate-acting (Semilente®) insulin. The sauna (twice for 25 min at 85 °C) failed to stimulate insulin absorption significantly or to lower blood glucose levels as compared to a control day at 22 °C. Thus, heat has a different effect on the pharmacokinetics of amorphous and soluble insulins.
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Koivisto, V.A. Influence of heat on insulin absorption: Different effects on amorphous and soluble insulins. Acta diabet. lat 20, 174–178 (1983). https://doi.org/10.1007/BF02624918
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DOI: https://doi.org/10.1007/BF02624918