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Frailty

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Zusammenfassung

Frailty (Gebrechlichkeit) ist das zentrale altersmedizinische Syndrom. Auf der Basis von Alter, Alterungsprozessen, chronischen Erkrankungen, Multimorbidität und Polymedikation kommt es zu funktionellen Einbußen mit einer erhöhten Vulnerabilität und einer erhöhten Wahrscheinlichkeit von Morbidität, Institutionalisierung, Pflegebedürftigkeit und Tod. Das Frailty-Syndrom umfasst physische, psychische und soziale Aspekte. In den Screeningverfahren werden zwischen 5 bis 70 Parameter berücksichtigt. Die zentralen physischen Aspekte der Frailty beinhalten Gewichtsabnahme, eingeschränkte Belastbarkeit, motorische Kraft, Geschwindigkeit und Ausdauer. Prophylaxe und Therapie des Frailty-Syndroms beinhalten die Behandlung der aktiven Komorbiditäten, Optimierung der Medikation und des Ernährungsstatus in Kombination mit Physiotherapie und ADL-Training sowie Berücksichtigung von Umgebungsfaktoren. Auf diese Weise können Aktivität, Mobilität, soziale Teilhabe und Lebensqualität positiv moduliert werden.

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Literatur

  • Albala C, Lera L, Sanchez H, Angel B, Márquez C, Arroyo P, Fuentes P (2017) Frequency of frailty and its association with cognitive status and survival in older Chileans. Clin Interv Aging 12:995–1001

    Article  PubMed  PubMed Central  Google Scholar 

  • Andrews JS, Trupin L, Yelin EH, Hough CL, Covinsky KE, Katz PP (2017) Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study. Clin Rheumatol 36:1031–1039

    Google Scholar 

  • Arts MH, Collard RM, Comijs HC, Zuidersma M, de Rooij SE, Naarding P, Oude Voshaar RC (2016) Physical frailty and cognitive functioning in depressed older adults: findings from the NESDO study. J Am Med Dir Assoc 17:36–43

    Article  PubMed  Google Scholar 

  • Azzopardi RV, Vermeiren S, Gorus E, Habbig AK, Petrovic M, Van Den Noortgate N, De Vriendt P, Bautmans I, Beyer I, Group GBS (2016) Linking frailty instruments to the international classification of functioning, disability, and health: a systematic review. J Am Med Dir Assoc 17:1066. e1–e11

    Google Scholar 

  • Baek SH, Lee SW, Kim SW, Ahn SY, Yu MY, Kim KI, Chin HJ, Na KY, Chae DW, Kim S (2016) Frailty as a predictor of acute kidney injury in hospitalized elderly patients: a single center, retrospective cohort study. PLoS One 11:e0156444

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ballew SH, Chen Y, Daya NR, Godino JG, Windham BG, McAdams-DeMarco M, Coresh J, Selvin E, Grams ME (2017) Frailty, kidney function, and polypharmacy: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 69:228–236

    Article  PubMed  Google Scholar 

  • Basic D, Shanley C (2015) Frailty in an older inpatient population: using the clinical frailty scale to predict patient outcomes. J Aging Health 27:670–685

    Article  PubMed  Google Scholar 

  • Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie Y (2013) Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 14:542–559

    Article  PubMed  Google Scholar 

  • Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, Lloyd-Sherlock P, Epping-Jordan JE, Peeters GMEE, Mahanani WR, Thiyagarajan JA, Chatterji S (2016) The world report on ageing and health: a policy framework for healthy ageing. Lancet 387:2145–2154

    Article  PubMed  Google Scholar 

  • Bone AE, Hepgul N, Kon S, Maddocks M (2017) Sarcopenia and frailty in chronic respiratory disease. Chron Respir Dis 14:85–99

    Article  PubMed  PubMed Central  Google Scholar 

  • Bray NW, Smart RR, Jakobi JM, Jones GR (2016) Exercise prescription to reverse frailty. Appl Physiol Nutr Metab 41:1112–1116

    Article  PubMed  Google Scholar 

  • Bruyère O, Buckinx F, Beaudart C, Reginster JY, Bauer J, Cederholm T, Cherubini A, Cooper C, Cruz-Jentoft AJ, Landi F, Maggi S, Rizzoli R, Sayer AA, Sieber C, Vellas B (2017) Cesari M, group EatEfw. How clinical practitioners assess frailty in their daily practice: an international survey. Aging Clin Exp Res 29:905–912

    Article  PubMed  PubMed Central  Google Scholar 

  • Buchman AS, Schneider JA, Leurgans S, Bennett DA (2008) Physical frailty in older persons is associated with Alzheimer disease pathology. Neurology 71:499–504

    Article  PubMed  PubMed Central  Google Scholar 

  • Buchman AS, Yu L, Wilson RS, Schneider JA, Bennett DA (2013) Association of brain pathology with the progression of frailty in older adults. Neurology 80:2055–2061

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Buckinx F, Reginster JY, Petermans J, Croisier JL, Beaudart C, Brunois T, Bruyère O (2016) Relationship between frailty, physical performance and quality of life among nursing home residents: the SENIOR cohort. Aging Clin Exp Res 28:1149–1157

    Article  CAS  PubMed  Google Scholar 

  • Buta B, Choudhury PP, Xue QL, Chaves P, Bandeen-Roche K, Shardell M, Semba RD, Walston J, Michos ED, Appel LJ, McAdams-DeMarco M, Gross A, Yasar S, Ferrucci L, Fried LP, Kalyani RR (2017) The association of vitamin D deficiency and incident frailty in older women: the role of cardiometabolic diseases. J Am Geriatr Soc 65:619–624

    Article  PubMed  Google Scholar 

  • Cesari M, Demougeot L, Boccalon H, Guyonnet S, Abellan Van Kan G, Vellas B, Andrieu S (2014) A self-reported screening tool for detecting community-dwelling older persons with frailty syndrome in the absence of mobility disability: the FiND questionnaire. PLoS One 9:e101745

    Google Scholar 

  • Cesari M, Pérez-Zepeda MU, Marzetti E (2017) Frailty and multimorbidity: different ways of thinking about geriatrics. J Am Med Dir Assoc 18:361–364

    Article  PubMed  Google Scholar 

  • Chung CP, Chou KH, Chen WT, Liu LK, Lee WJ, Chen LK, Lin CP, Wang PN (2016) Cerebral microbleeds are associated with physical frailty: a community-based study. Neurobiol Aging 44:143–150

    Article  PubMed  Google Scholar 

  • Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, Mohammed MA, Parry J, Marshall T (2016) Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing 45:353–360

    Article  PubMed  PubMed Central  Google Scholar 

  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K (2013) Frailty in elderly people. Lancet 381:752–762

    Article  PubMed  Google Scholar 

  • Collard RM, Boter H, Schoevers RA, Oude Voshaar RC (2012) Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 60:1487–1492

    Article  PubMed  Google Scholar 

  • Cook MJ, Oldroyd A, Pye SR, Ward KA, Gielen E, Ravindrarajah R, Adams JE, Lee DM, Bartfai G, Boonen S, Casanueva F, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Vanderschueren D, Wu FC, O’Neill TW, Group ES (2017) Frailty and bone health in European men. Age Ageing 46:635–641

    Google Scholar 

  • Crow RS, Lohman MC, Titus AJ, Bruce ML, Mackenzie TA, Bartels SJ, Batsis JA (2018) Mortality risk along the frailty spectrum: data from the National Health and Nutrition Examination Survey 1999 to 2004. J Am Geriatr Soc 66:496–502

    Article  PubMed  PubMed Central  Google Scholar 

  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M (2010) People EWGoSiO. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423

    Article  PubMed  PubMed Central  Google Scholar 

  • Da Mata FA, Pereira PP, Andrade KR, Figueiredo AC, Silva MT, Pereira MG (2016) Prevalence of frailty in Latin America and the Caribbean: a systematic review and meta-analysis. PLoS One 11:e0160019

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dedeyne L, Deschodt M, Verschueren S, Tournoy J, Gielen E (2017) Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review. Clin Interv Aging 12:873–896

    Article  PubMed  PubMed Central  Google Scholar 

  • Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G (2017) Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev 75:114–128

    Article  PubMed  Google Scholar 

  • Ding YY, Kuha J, Murphy M (2017) Multidimensional predictors of physical frailty in older people: identifying how and for whom they exert their effects. Biogerontology 18:237–252

    Article  PubMed  PubMed Central  Google Scholar 

  • Dury S, Dierckx E, van der Vorst A, Van der Elst M, Fret B, Duppen D, Hoeyberghs L, De Roeck E, Lambotte D, Smetcoren AS, Schols J, Kempen G, Zijlstra GAR, De Lepeleire J, Schoenmakers B, Verté D, De Witte N, Kardol T, De Deyn PP, Engelborghs S, De Donder L (2018) Detecting frail, older adults and identifying their strengths: results of a mixed-methods study. BMC Public Health 18:191

    Article  PubMed  PubMed Central  Google Scholar 

  • Easton JF, Stephens CR, Angelova M (2014) Risk factors and prediction of very short term versus short/intermediate term post-stroke mortality: a data mining approach. Comput Biol Med 54:199–210

    Article  PubMed  Google Scholar 

  • Ekerstad N, Dahlin Ivanoff S, Landahl S, Östberg G, Johansson M, Andersson D, Husberg M, Alwin J, Karlson BW (2017a) Acute care of severely frail elderly patients in a CGA-unit is associated with less functional decline than conventional acute care. Clin Interv Aging 12:1239–1249

    Article  PubMed  PubMed Central  Google Scholar 

  • Ekerstad N, Karlson BW, Dahlin Ivanoff S, Landahl S, Andersson D, Heintz E, Husberg M, Alwin J (2017b) Is the acute care of frail elderly patients in a comprehensive geriatric assessment unit superior to conventional acute medical care? Clin Interv Aging 12:1–9

    Article  PubMed  Google Scholar 

  • Farcet A, de Decker L, Pauly V, Rousseau F, Bergman H, Molines C, Retornaz F (2016) Frailty markers and treatment decisions in patients seen in oncogeriatric clinics: results from the ASRO pilot study. PLoS One 11:e0149732

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Franse CB, van Grieken A, Qin L, Melis RJF, Rietjens JAC, Raat H (2017) Socioeconomic inequalities in frailty and frailty components among community-dwelling older citizens. PLoS One 12:e0187946

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Freiberger E, Kemmler W, Siegrist M, Sieber C (2016) Frailty and exercise interventions: evidence and barriers for exercise programs. Z Gerontol Geriatr 49:606–611

    Article  CAS  PubMed  Google Scholar 

  • Freitag S, Schmidt S, Gobbens RJ (2016) Tilburg frailty indicator. German translation and psychometric testing. Z Gerontol Geriatr 49:86–93

    Article  CAS  PubMed  Google Scholar 

  • Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA (2001) Group CHSCR. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156

    Article  CAS  PubMed  Google Scholar 

  • Fuchs J, Scheidt-Nave C, Gaertner B, Dapp U, von Renteln-Kruse W, Saum KU, Thorand B, Strobl R, Grill E (2016) Frailty in Germany: status and perspectives: Results from a workshop of the German Society for Epidemiology. Z Gerontol Geriatr 49:734–742

    Article  PubMed  Google Scholar 

  • Gale CR, Westbury L, Cooper C (2017) Social isolation and loneliness as risk factors for the progression of frailty: the English Longitudinal Study of Ageing. Age Ageing 47(3):392–397

    Google Scholar 

  • García-Esquinas E, Pérez-Hernández B, Guallar-Castillón P, Banegas JR, Ayuso-Mateos JL, Rodríguez-Artalejo F (2016a) Housing conditions and limitations in physical function among older adults. J Epidemiol Community Health 70:954–960

    Article  PubMed  Google Scholar 

  • García-Esquinas E, Rahi B, Peres K, Colpo M, Dartigues JF, Bandinelli S, Feart C, Rodríguez-Artalejo F (2016b) Consumption of fruit and vegetables and risk of frailty: a dose-response analysis of 3 prospective cohorts of community-dwelling older adults. Am J Clin Nutr 104:132–142

    Article  PubMed  CAS  Google Scholar 

  • García-Esquinas E, Rodríguez-Artalejo F (2017) Environmental pollutants, limitations in physical functioning, and frailty in older adults. Curr Environ Health Rep 4:12–20

    Article  PubMed  CAS  Google Scholar 

  • Haider S, Luger E, Kapan A, Titze S, Lackinger C, Schindler KE, Dorner TE (2016) Associations between daily physical activity, handgrip strength, muscle mass, physical performance and quality of life in prefrail and frail community-dwelling older adults. Qual Life Res 25:3129–3138

    Article  PubMed  PubMed Central  Google Scholar 

  • Henchoz Y, Büla C, Guessous I, Santos-Eggimann B (2017) Association between physical frailty and quality of life in a representative sample of community-dwelling swiss older people. J Nutr Health Aging 21:585–592

    Article  CAS  PubMed  Google Scholar 

  • Herr M, Arvieu JJ, Robine JM, Ankri J (2016) Health, frailty and disability after ninety: results of an observational study in France. Arch Gerontol Geriatr 66:166–175

    Article  CAS  PubMed  Google Scholar 

  • Jacobs AH (2012) Tavitian B, consortium I. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab 32:1393–1415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacobs AH (2018) Alterspharmakologie. Arzneimitteltherapie 4:117–118

    Google Scholar 

  • Jacobs AH, Grond M, Dodel R, Maetzler W (2017) Neurogeriatrie. In: Diener H, Gerloff C, Dieterich M, (eds) Therapie und Verlauf neurologischer Erkrankungen 7. Aufl. Kohlhammer, Stuttgart, S 1607–1622

    Google Scholar 

  • Jankowska-Polańska B, Dudek K, Szymanska-Chabowska A, Uchmanowicz I (2016) The influence of frailty syndrome on medication adherence among elderly patients with hypertension. Clin Interv Aging 11:1781–1790

    Article  PubMed  PubMed Central  Google Scholar 

  • Kobe AR, Meyer A, Elmubarak H, Kempfert J, Pavicevic J, Maisano F, Walther T, Falk V, Sündermann SH (2016) Frailty assessed by the FORECAST is a valid tool to predict short-term outcome after transcatheter aortic valve replacement. Innovations (Phila) 11:407–413

    Article  Google Scholar 

  • Kojima G, Iliffe S, Morris RW, Taniguchi Y, Kendrick D, Skelton DA, Masud T, Bowling A (2016) Frailty predicts trajectories of quality of life over time among British community-dwelling older people. Qual Life Res 25:1743–1750

    Article  PubMed  PubMed Central  Google Scholar 

  • Kojima G, Iliffe S, Walters K (2018) Frailty index as a predictor of mortality: a systematic review and meta-analysis. Age Ageing 47:193–200

    Article  PubMed  Google Scholar 

  • Kotajarvi BR, Schafer MJ, Atkinson EJ, Traynor MM, Bruce CJ, Greason KL, Suri RM, Miller JD, LeBrasseur NK (2017) The impact of frailty on patient-centered outcomes following aortic valve replacement. J Gerontol A Biol Sci Med Sci 72:917–921

    Article  PubMed  PubMed Central  Google Scholar 

  • Kramer DB, Tsai T, Natarajan P, Tewksbury E, Mitchell SL, Travison TG (2017) Frailty, physical activity, and mobility in patients with cardiac implantable electrical devices. J Am Heart Assoc 6(2):e004659

    Google Scholar 

  • Kucharska-Newton AM, Palta P, Burgard S, Griswold ME, Lund JL, Capistrant BD, Kritchevsky SB, Bandeen-Roche K, Windham BG (2017) Operationalizing frailty in the atherosclerosis risk in communities study cohort. J Gerontol A Biol Sci Med Sci 72:382–388

    PubMed  Google Scholar 

  • Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S (2017) Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology 66:564–574

    Article  PubMed  Google Scholar 

  • Landi F, Calvani R, Cesari M, Tosato M, Martone AM, Bernabei R, Onder G, Marzetti E (2015) Sarcopenia as the biological substrate of physical frailty. Clin Geriatr Med 31:367–374

    Article  PubMed  Google Scholar 

  • Landi F, Cesari M, Calvani R, Cherubini A, Di Bari M, Bejuit R, Mshid J, Andrieu S, Sinclair AJ, Sieber CC, Vellas B, Topinkova E, Strandberg T, Rodriguez-Manas L, Lattanzio F, Pahor M, Roubenoff R, Cruz-Jentoft AJ, Bernabei R, Marzetti E, Consortium S (2017) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. Aging Clin Exp Res 29:89–100

    Google Scholar 

  • Lee DR, Kawas CH, Gibbs L, Corrada MM (2016a) Prevalence of frailty and factors associated with frailty in individuals aged 90 and older: the 90+ study. J Am Geriatr Soc 64:2257–2262

    Article  PubMed  Google Scholar 

  • Lee WJ, Chen LK, Liang CK, Peng LN, Chiou ST, Chou P (2016b) Soluble ICAM-1, Independent of IL-6, is associated with prevalent frailty in community-dwelling elderly taiwanese people. PLoS One 11:e0157877

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li G, Papaioannou A, Thabane L, Cheng J, Adachi JD (2016) Frailty change and major osteoporotic fracture in the elderly: data from the global longitudinal study of osteoporosis in women 3-year hamilton cohort. J Bone Miner Res 31:718–724

    Article  PubMed  Google Scholar 

  • Liu CK, Lyass A, Larson MG, Massaro JM, Wang N, D’Agostino RB, Benjamin EJ, Murabito JM (2016) Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study. Age (Dordr) 38:1

    Article  CAS  Google Scholar 

  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153:1194–1217

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Luger E, Haider S, Kapan A, Schindler K, Lackinger C, Dorner TE (2016) Association between nutritional status and quality of life in (Pre) frail community-dwelling older persons. J Frailty Aging 5:141–148

    CAS  PubMed  Google Scholar 

  • Marzetti E, Calvani R, Tosato M, Cesari M, Di Bari M, Cherubini A, Broccatelli M, Savera G, D’Elia M, Pahor M, Bernabei R, Landi F, Consortium S (2017) Physical activity and exercise as countermeasures to physical frailty and sarcopenia. Aging Clin Exp Res 29:35–42

    Google Scholar 

  • McAdams-DeMarco MA, Olorundare IO, Ying H, Warsame F, Haugen CE, Hall R, Garonzik-Wang JM, Desai NM, Walston JD, Norman SP, Segev DL (2018) Frailty and postkidney transplant health-related quality of life. Transplantation 102:291–299

    Article  PubMed  PubMed Central  Google Scholar 

  • McIsaac DI, Jen T, Mookerji N, Patel A, Lalu MM (2017) Interventions to improve the outcomes of frail people having surgery: a systematic review. PLoS One 12:e0190071

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mirón Mombiela R, Facal de Castro F, Moreno P, Borras C (2017) Ultrasonic echo intensity as a new noninvasive in vivo biomarker of frailty. J Am Geriatr Soc 65:2685–2690

    Article  PubMed  Google Scholar 

  • Mitnitski AB, Mogilner AJ, Rockwood K (2001) Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal 1:323–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J (2013) Frailty consensus: a call to action. J Am Med Dir Assoc 14:392–397

    Article  PubMed  PubMed Central  Google Scholar 

  • Mulasso A, Roppolo M, Giannotta F, Rabaglietti E (2016) Associations of frailty and psychosocial factors with autonomy in daily activities: a cross-sectional study in Italian community-dwelling older adults. Clin Interv Aging 11:37–45

    PubMed  PubMed Central  Google Scholar 

  • Nadruz W, Kitzman D, Windham BG, Kucharska-Newton A, Butler K, Palta P, Griswold ME, Wagenknecht LE, Heiss G, Solomon SD, Skali H, Shah AM (2017) Cardiovascular dysfunction and frailty among older adults in the community: the ARIC study. J Gerontol A Biol Sci Med Sci 72:958–964

    PubMed  Google Scholar 

  • Oosterveld SM, Kessels RP, Hamel R, Ramakers IH, Aalten P, Verhey FR, Sistermans N, Smits LL, Pijnenburg YA, van der Flier WM, Olde Rikkert MG, Melis RJ (2014) The influence of co-morbidity and frailty on the clinical manifestation of patients with Alzheimer’s disease. J Alzheimers Dis 42:501–509

    Article  PubMed  Google Scholar 

  • Ortolá R, García-Esquinas E, León-Muñoz LM, Guallar-Castillón P, Valencia-Martín JL, Galán I, Rodríguez-Artalejo F (2016) Patterns of alcohol consumption and risk of frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 71:251–258

    Article  PubMed  Google Scholar 

  • Peters LL, Boter H, Burgerhof JG, Slaets JP, Buskens E (2015) Construct validity of the Groningen Frailty Indicator established in a large sample of home-dwelling elderly persons: evidence of stability across age and gender. Exp Gerontol 69:129–141

    Article  CAS  PubMed  Google Scholar 

  • Poli S, Cella A, Puntoni M, Musacchio C, Pomata M, Torriglia D, Vello N, Molinari B, Pandolfini V, Torrigiani C, Pilotto A (2017) Frailty is associated with socioeconomic and lifestyle factors in community-dwelling older subjects. Aging Clin Exp Res 29:721–728

    Article  PubMed  Google Scholar 

  • Pollack LR, Litwack-Harrison S, Cawthon PM, Ensrud K, Lane NE, Barrett-Connor E, Dam TT (2017) Patterns and predictors of frailty transitions in older men: the osteoporotic fractures in men study. J Am Geriatr Soc 65:2473–2479

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramirez-Campillo R, Diaz D, Martinez-Salazar C, Valdés-Badilla P, Delgado-Floody P, Méndez-Rebolledo G, Cañas-Jamet R, Cristi-Montero C, García-Hermoso A, Celis-Morales C, Moran J, Buford TW, Rodriguez-Mañas L, Alonso-Martinez AM, Izquierdo M (2016) Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: a randomized controlled trial. Clin Interv Aging 11:1797–1804

    Article  PubMed  PubMed Central  Google Scholar 

  • Rich MW, Chyun DA, Skolnick AH, Alexander KP, Forman DE, Kitzman DW, Maurer MS, McClurken JB, Resnick BM, Shen WK, Tirschwell DL (2016) Knowledge gaps in cardiovascular care of older adults: a scientific statement from the American heart association, American college of cardiology, and American geriatrics society: executive summary. J Am Geriatr Soc 64:2185–2192

    Article  PubMed  Google Scholar 

  • Ritt M, Gaßmann KG, Sieber CC (2016) Significance of frailty for predicting adverse clinical outcomes in different patient groups with specific medical conditions. Z Gerontol Geriatr 49:567–572

    Article  PubMed  Google Scholar 

  • Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495

    Article  PubMed  PubMed Central  Google Scholar 

  • Rockwood K, Stolee P, McDowell I (1996) Factors associated with institutionalization of older people in Canada: testing a multifactorial definition of frailty. J Am Geriatr Soc 44:578–582

    Article  CAS  PubMed  Google Scholar 

  • Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, Gonzalez-Colaço Harmand M, Bergman H, Carcaillon L, Nicholson C, Scuteri A, Sinclair A, Pelaez M, Van der Cammen T, Beland F, Bickenbach J, Delamarche P, Ferrucci L, Fried LP, Gutiérrez-Robledo LM, Rockwood K, Rodríguez Artalejo F, Serviddio G, Vega E, 1) F-CgA (2013) Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci 68:62–67

    Google Scholar 

  • Rodríguez-Pascual C, Paredes-Galán E, Ferrero-Martínez AI, Gonzalez-Guerrero JL, Hornillos-Calvo M, Menendez-Colino R, Torres-Torres I, Vilches-Moraga A, Galán MC, Suarez-Garcia F, Olcoz-Chiva MT, Rodríguez-Artalejo F (2017) The frailty syndrome is associated with adverse health outcomes in very old patients with stable heart failure: a prospective study in six Spanish hospitals. Int J Cardiol 236:296–303

    Article  PubMed  Google Scholar 

  • Rogers NT, Marshall A, Roberts CH, Demakakos P, Steptoe A, Scholes S (2017) Physical activity and trajectories of frailty among older adults: evidence from the English Longitudinal Study of Ageing. PLoS One 12:e0170878

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Roland KP, Jakobi JM, Jones GR, Powell C (2012) Quality of life as a determinant of frailty phenotype in community-dwelling persons with Parkinson’s disease. J Am Geriatr Soc 60:590–592

    Article  PubMed  Google Scholar 

  • Rønning B, Wyller TB, Nesbakken A, Skovlund E, Jordhøy MS, Bakka A, Rostoft S (2016) Quality of life in older and frail patients after surgery for colorectal cancer-A follow-up study. J Geriatr Oncol 7:195–200

    Article  PubMed  Google Scholar 

  • Santos-Eggimann B, Cuénoud P, Spagnoli J, Junod J (2009) Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. J Gerontol A Biol Sci Med Sci 64:675–681

    Article  PubMed  Google Scholar 

  • Shinkai S, Yoshida H, Taniguchi Y, Murayama H, Nishi M, Amano H, Nofuji Y, Seino S, Fujiwara Y (2016) Public health approach to preventing frailty in the community and its effect on healthy aging in Japan. Geriatr Gerontol Int 16(1):87–97

    Article  PubMed  Google Scholar 

  • Sieber CC (2017) Frailty – from concept to clinical practice. Exp Gerontol 87:160–167

    Article  PubMed  Google Scholar 

  • Tarazona-Santabalbina FJ, Gómez-Cabrera MC, Pérez-Ros P, Martínez-Arnau FM, Cabo H, Tsaparas K, Salvador-Pascual A, Rodriguez-Mañas L, Viña J (2016) A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc 17:426–433

    Article  PubMed  Google Scholar 

  • Theou O, Blodgett JM, Godin J, Rockwood K (2017) Association between sedentary time and mortality across levels of frailty. CMAJ 189:E1056–E1064

    Article  PubMed  PubMed Central  Google Scholar 

  • Ticinesi A, Meschi T, Lauretani F, Felis G, Franchi F, Pedrolli C, Barichella M, Benati G, Di Nuzzo S, Ceda GP, Maggio M (2016) Nutrition and inflammation in older individuals: focus on vitamin D, n-3 polyunsaturated fatty acids and whey proteins. Nutrients 8:186

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Toosizadeh N, Stocker H, Thiede R, Mohler J, Mills JL, Najafi B (2016) Alterations in gait parameters with peripheral artery disease: the importance of pre-frailty as a confounding variable. Vasc Med 21:520–527

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H (2017) The association between anorexia of aging and physical frailty: results from the national center for geriatrics and gerontology’s study of geriatric syndromes. Maturitas 97:32–37

    Google Scholar 

  • Vellas B, Balardy L, Gillette-Guyonnet S, Abellan Van Kan G, Ghisolfi-Marque A, Subra J, Bismuth S, Oustric S, Cesari M (2013) Looking for frailty in community-dwelling older persons: the Gérontopôle Frailty Screening Tool (GFST). J Nutr Health Aging 17:629–631

    Article  CAS  PubMed  Google Scholar 

  • Vidán MT, Blaya-Novakova V, Sánchez E, Ortiz J, Serra-Rexach JA, Bueno H (2016) Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure. Eur J Heart Fail 18:869–875

    Article  PubMed  CAS  Google Scholar 

  • Wardlaw JM, Valdés Hernández MC, Muñoz-Maniega S (2015) What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc 4:001140

    Article  PubMed  Google Scholar 

  • Yannakoulia M, Ntanasi E, Anastasiou CA, Scarmeas N (2017) Frailty and nutrition: from epidemiological and clinical evidence to potential mechanisms. Metabolism 68:64–76

    Article  CAS  PubMed  Google Scholar 

  • Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D (2013) Hypothalamic programming of systemic ageing involving IKK-β. NF-κB and GnRH. Nature 497:211–216

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Geriatrie mit Neurologie, Johanniter Krankenhaus Bonn, Bonn, Deutschland

    Andreas H. Jacobs

  2. Klinik für Allgemeine Innere Medizin und Geriatrie, Franziskushospital Aachen GmbH, Heidelberg, Deutschland

    Cornelius Bollheimer

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  1. Andreas H. Jacobs
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  2. Cornelius Bollheimer
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Correspondence to Andreas H. Jacobs .

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Editors and Affiliations

  1. Klinik für Neurologie, UKSH, Campus Kiel, Kiel, Germany

    Walter Maetzler

  2. Lehrstuhl für Geriatrie, Universitätsklinikum Essen, Geriatriezentrum Haus Berge, Contilia Group, Essen, Germany

    Richard Dodel

  3. Klinik für Geriatrie mit Neurologie, Johanniter Krankenhaus Bonn, Bonn, Germany

    Andreas H. Jacobs

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Jacobs, A.H., Bollheimer, C. (2019). Frailty. In: Maetzler, W., Dodel, R., Jacobs, A. (eds) Neurogeriatrie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57358-7_5

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  • DOI: https://doi.org/10.1007/978-3-662-57358-7_5

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