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Zusammenfassung

Maligne Tumoren der Haut sind die häufigste Krebsart des Menschen. Basalzellkarzinome werden in einem anderen Kapitel abgehandelt (Kap. „Basalzellkarzinom“), während die weiteren epithelialen malignen Tumoren hier betrachtet werden. Die Ursachen von Hautkrebs sind vielfältig und umfassen genetische Faktoren, wie beispielsweise eine herabgesetzte DNA-Reparaturkapazität, exogene kanzerogene Faktoren (überwiegend UV-Bestrahlung), aber auch verschiedene humane Papillomviren (HPV), chemische Karzinogene, ionisierende Strahlen und Immunsuppression. Individuelle Faktoren, wie etwa Hautfarbe, Dicke des Stratum corneum, Immunstatus oder chronisch entzündliche Erkrankungen der Haut, können weitere Risikofaktoren sein.

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Literatur

Allgemeine Literatur

  • Bernardi MP, Ngan SY, Michael M et al (2015) Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention. Lancet Oncol https://doi.org/10.1016/S1470-2045(15)00292-2

  • Ridky TW (2007) Nonmelanoma skin cancer. J Am Acad Dermatol 57:484–501

    Article  PubMed  Google Scholar 

  • Stockfleth, E, Rosen T, Schumaak S (Hrsg) (2010) Managing skin cancer. Springer Berlin S. 226

    Google Scholar 

  • Tuttleton Arron S, Jennings L, Nindl I et al (2011) Viral oncogenesis and its role in nonmelanoma skin cancer. Br J Dermatol 164:1201–1213

    Article  CAS  PubMed  Google Scholar 

Aktinische Keratosen

  • Feldman SR, Fleischer AB Jr (2011) Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications. Cutis 87:201–207

    PubMed  Google Scholar 

  • Heaphy MR Jr, Ackerman AB (2000) The nature of solar keratosis: a critical review in historical perspective. J Am Acad Dermatol 43:138–150

    Article  PubMed  Google Scholar 

  • Martin GM, Stockfleth E (2012) Diclofenac sodium 3 % gel for the management of actinic keratosis: 10+ years of cumulative evidence of efficacy and safety. J Drugs Dermatol 11:600–608

    PubMed  CAS  Google Scholar 

  • Stockfleth E, Ferandiz C, Grob JJ et al (2008) Development of a treatment algorithm for actinic keratoses; A European Consensus. Eur J Dermatol 18:651–659

    PubMed  Google Scholar 

  • Stockfleth E, Terhorst D, Braathen L et al (2011) on behalf of the European Dermatology Forum: Guideline for the management of actinic keratoses. www.euroderm.org

  • Werner RN, Stockfleth E, Connoly SM et al (2015) Evidence- and consensus-based (S3) Guidelines for the Treatment of Actinic Keratosis – International League of Dermatological Societies in cooperation with the European. Dermatology Forum – Short version, JEADV 29:2069–2079

    PubMed  CAS  Google Scholar 

Andere Carcinomata in situ

Verruköses Karzinom

Keratoakanthom

  • Annest NM, VanBeek MJ, Arpey CJ et al (2007) Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature. J Am Acad Dermatol 56:989–993

    Article  PubMed  Google Scholar 

  • D’Alessandro M, Coats SE, Morley SM et al (2007) Multiple self-healing squamous epithelioma in different ethnic groups: More than a founder mutation disorder? J Invest Dermatol 127:2336–2344

    Article  CAS  PubMed  Google Scholar 

  • Esser AC, Abril A, Fayne S, Doyle JA (2004) Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab. J Am Acad Dermatol 50(5 Suppl):S75–S77

    Article  PubMed  Google Scholar 

  • Kong HH, Cowen EW, Azad NS et al (2007) Keratoacanthomas associated with sorafenib therapy. J Am Acad Dermatol 56:171–172

    Article  PubMed  PubMed Central  Google Scholar 

  • Kwiek B, Schwartz RA, Keratoacanthoma KA (2016) An update and review. J Am Acad Dermatol 74:1220–1233

    Article  PubMed  Google Scholar 

  • Schwartz RA (1994) Keratoacanthoma. J Am Acad Dermatol 30:1–22

    Article  CAS  PubMed  Google Scholar 

Spinozelluläres Karzinom

  • Alam M, Ratner D (2001) Cutaneous squamous-cell carcinoma. N Engl J Med 344:975–983

    Article  CAS  PubMed  Google Scholar 

  • Brantsch KD, Meisner C, Schonfisch B et al (2008) Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncology 9:713–720

    Article  PubMed  Google Scholar 

  • Breuninger H, Bootz F, Hauschild A et al (2008) Kurzleitlinie – Plattenepitelkarzinom der Haut. J Dtsch Dermatol Ges 6:S5–S8

    Article  PubMed  Google Scholar 

  • Cassarino DS, Derienzo DP, Barr RJ (2006a) Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part I. J Cutan Pathol 33:191–206

    PubMed  Google Scholar 

  • Cassarino DS, Derienzo DP, Barr RJ (2006b) Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part II. J Cutan Pathol 33:261–279

    Article  PubMed  Google Scholar 

  • Combemale P, Bousquet M, Kanitakis J et al (2007) Malignant transformation of leg ulcers: A retrospective study of 85 cases. J Eur Acad Dermatol Venereol 21:935–941

    Article  CAS  PubMed  Google Scholar 

  • Farasat S, SS Y, Neel VA et al (2011) A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol 64:1051–1059

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim M, Murrell DF (2015) Update on the pathogenesis of squamous cell carcinoma development in recessive dystrophic epidermolysis bullosa. Eur J Dermatol 25(Suppl 1):30–32

    PubMed  CAS  Google Scholar 

  • Lambert SR, Mladkova N, Gulati A et al (2014) Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. Br J Cancer 110:520–529

    Article  CAS  PubMed  Google Scholar 

  • Micali G, Nasca MR, Innocenzi D, Schwartz RA (2006) Penile cancer. J Am Acad Dermatol 54:369–391

    Article  PubMed  Google Scholar 

  • Motley R, Kersey P, Lawrence C (2002) Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 146:18–25

    Article  CAS  PubMed  Google Scholar 

  • Nissinen L, Farshchian M, Riihilä P, Kähäri VM (2016) New perspectives on role of tumor microenvironment in progression of cutaneous squamous cell carcinoma. Cell Tissue Res 365:691–702

    Article  CAS  PubMed  Google Scholar 

Tumoren bei immunosupprimierten Patienten

  • Lonsdorf AS, Becker MR, Stockfleth E et al (2010) Primary and secondary prevention of skin cancer in organ transplant recipients. Hautarzt 6:195–206

    Article  Google Scholar 

  • Ulrich C, Kanitakis J, Stockfleth E, Euvrard S (2008) Skin cancer in organ transplant recipients – where do we stand today? Am J Transplant 8:2192–2198

    Article  CAS  PubMed  Google Scholar 

  • Zwald FO, Brown M (2011a) Skin cancer in solid organ transplant recipients: advances in therapy and management: Part I. Epidemiology of skin cancer in solid organ transplant recipients. J Am Acad Dermatol 65:253–261

    Article  Google Scholar 

  • Zwald FO, Brown M (2011b) Skin cancer in solid organ transplant recipients: advances in therapy and management: Part II. Management of skin cancer in solid organ transplant recipients. J Am Acad Dermatol 65:263–279

    Article  Google Scholar 

Kutane Metastasen

  • Fernandez-Flores A (2010) Cutaneous metastases: a study of 78 biopsies from 69 patients. Am J Dermatopathol 2:222–239

    Google Scholar 

  • Lookingbill DP, Spangler N, Helm KF (1993) Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 29:228–236

    Article  CAS  PubMed  Google Scholar 

  • Schwartz RA (1995) Histopathologic aspects of cutaneous metastatic disease. J Am Acad Dermatol 33:649–657

    Article  CAS  PubMed  Google Scholar 

Erstbeschreiber

  • Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surgery 23:670–678

    PubMed  CAS  Google Scholar 

  • Aird I, Johnson HD, Lennox B et al (1954) Epithelioma cuniculatum. A variety of squamous carcinoma peculiar to the foot. Br J Surg 42:245–250

    Article  CAS  PubMed  Google Scholar 

  • Bowen JT (1912) Precancerous dermatoses: a study of two cases of chronic atypical epithelial proliferation. J Cutan Dis 30:241–255

    Google Scholar 

  • Buschke A, Löwenstein L (1925) Über carcinomähnliche Condylomata acuminata des Penis. Berlin. Klin Wochenschr 4:1726–1728

    Article  Google Scholar 

  • Diaz-Cascajo C, Borghi S, Weyers W et al (2004) Follicular squamous cell carcinoma of the skin: a poorly recognized neoplasm arising from the wall of hair follicles. J Cutan Pathol 31:19–25

    Article  PubMed  Google Scholar 

  • Dubreuilh W (1896) Des hyperkératoses circonscrites. Ann Dermatol Vénérol 27:1158–1204

    Google Scholar 

  • Dupont A (1930) Kyste sébacé atypique. Bull Soc Belge Dermatol:177–179

    Google Scholar 

  • Ferguson-Smith J (1934) A case of multiple primary squamous-cell carcinomata of the skin in a young man with spontaneous healing. Br J Dermatol 46:267–272

    Article  Google Scholar 

  • Freudenthal W (1926) Verruca senilis und Keratoma senile. Arch Dermatol Syph 152:505–528

    Article  Google Scholar 

  • Gottron HA (1932) Ausgedehnte, ziemlich symmetrisch angeordnete Papillomatosis cutis. Zentralbl Haut Geschlechtskr 40:445

    Google Scholar 

  • Grzybowski M (1950) A case of peculiar generalized epithelial tumors of the skin. Br J Dermatol 62:310–313

    Article  CAS  Google Scholar 

  • Hutchinson J (1889) The crateriform ulcer of the face, a form of acute epithelial cancer. Trans Pathol Soc London 40:275–281

    Google Scholar 

  • Marjolin JN (1828) Ulcère. Dictionnaire de Médecine 21:31–50

    Google Scholar 

  • Mayo WJ (1928) Metastases in cancer. Proc Staff Meet Mayo Clinic 3:327. Dr. Mayo war der Chef von Sister Mary Joseph, und hat deren Beobachtung publiziert

    Google Scholar 

  • Miedzinski F, Kosakiewicz J (1962) Das Keratoakanthoma centrifugum – eine besondere Varietät des Keratoakanthoms. Hautarzt 13:348–352

    Google Scholar 

  • Neumann I (1869) Über die senilen Veränderungen der Haut. Sitzungsbericht der Akademie Wissenschaften Wien Mathematisch-naturwissenschaftliche Klasse

    Google Scholar 

  • Pott P (1775) Chirurgical observations relative to the cataract, the polypus of the nose, the cancer of the scrotum, the different kinds of ruptures and the martification of the toes and feet. Hawes, Clarke and Collins, London, S 63–68

    Google Scholar 

  • Queyrat M (1911) Érythroplasie du gland (1). (Planche I) Ann Dermatol Syph 5ème série. Tome II. Bull Soc Fr Dermatol Syph 22:378–382

    Google Scholar 

  • Rock JA, Fischer ER (1960) Florid papillomatosis of the oral cavity and larynx. Arch Otolaryngol 72:480–493

    Article  Google Scholar 

  • Witten VH, Zak FG (1952) Multiple primary, self-healing prickle-cell epithelioma of the skin. Cancer 5:539–550

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Wolfram Sterry .

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Sterry, W., Stockfleth, E. (2018). Maligne epitheliale Tumoren. In: Plewig, G., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco’s Dermatologie, Venerologie und Allergologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49544-5_102

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  • DOI: https://doi.org/10.1007/978-3-662-49544-5_102

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