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Physiologically Based Toxicokinetic (PBTK) Modeling in Ecotoxicology

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Ecotoxicology Modeling

Part of the book series: Emerging Topics in Ecotoxicology ((ETEP,volume 2))

Abstract

Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals in biota. PBTK models are increasingly being used as an effective tool for designing toxicology experiments and for conducting extrapolations essential for risk assessments. This chapter describes the basic concepts, equations, parameters, and software essential for developing PBTK models. QSAR methods for estimating input parameters as well as data sources containing relevant parameters for model development in rats, mice, cattle, birds, and fish are summarized. Model templates for creating PBTK models in fish and terrestrial species are presented. Several examples of model simulations are presented along with a brief discussion of how PBTK models can be applied to make significant advances in ecotoxicology and ecotoxicological risk assessments.

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Authors and Affiliations

  1. Département de santé environnementale et santé au travail, Pavillon Marguerite d’Youville, Université de Montréal, 2375 chemin de la Cote Ste Catherine, Montreal, PQ, Canada

    Kannan Krishnan & Thomas Peyret

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  1. Kannan Krishnan
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  2. Thomas Peyret
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Correspondence to Kannan Krishnan .

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  1. l'Information Scientifique (CTIS), Centre de Traitement de, chemin de la Graviere 3, Rillieux La Pape, 69140, France

    James Devillers

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Krishnan, K., Peyret, T. (2009). Physiologically Based Toxicokinetic (PBTK) Modeling in Ecotoxicology. In: Devillers, J. (eds) Ecotoxicology Modeling. Emerging Topics in Ecotoxicology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0197-2_6

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